BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 23609977)

  • 1. Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2.
    Zhan YA; Wu H; Powell AT; Daughdrill GW; Ytreberg FM
    Proteins; 2013 Oct; 81(10):1738-47. PubMed ID: 23609977
    [TBL] [Abstract][Full Text] [Related]  

  • 2. p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX.
    Levy R; Gregory E; Borcherds W; Daughdrill G
    Biomolecules; 2019 Mar; 9(3):. PubMed ID: 30832340
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition.
    Shin JS; Ha JH; Lee DH; Ryu KS; Bae KH; Park BC; Park SG; Yi GS; Chi SW
    Cell Cycle; 2015; 14(4):533-43. PubMed ID: 25591003
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes.
    Mihalič F; Arcila D; Pettersson ME; Farkhondehkish P; Andersson E; Andersson L; Betancur-R R; Jemth P
    Mol Biol Evol; 2024 Feb; 41(2):. PubMed ID: 38301272
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53·MDM2/MDMX interaction.
    Shan B; Li DW; Brüschweiler-Li L; Brüschweiler R
    J Biol Chem; 2012 Aug; 287(36):30376-84. PubMed ID: 22807444
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins.
    Lee MS; Ha JH; Yoon HS; Lee CK; Chi SW
    Biochem Biophys Res Commun; 2014 Feb; 445(1):120-5. PubMed ID: 24491548
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions.
    Mihalič F; Åberg E; Farkhondehkish P; Theys N; Andersson E; Jemth P
    Protein Sci; 2023 Jul; 32(7):e4684. PubMed ID: 37211711
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.
    Ha JH; Shin JS; Yoon MK; Lee MS; He F; Bae KH; Yoon HS; Lee CK; Park SG; Muto Y; Chi SW
    J Biol Chem; 2013 Mar; 288(10):7387-98. PubMed ID: 23316052
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins.
    Borcherds W; Kashtanov S; Wu H; Daughdrill GW
    Proteins; 2013 Oct; 81(10):1686-98. PubMed ID: 23606624
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Direct observations of conformational distributions of intrinsically disordered p53 peptides using UV Raman and explicit solvent simulations.
    Xiong K; Zwier MC; Myshakina NS; Burger VM; Asher SA; Chong LT
    J Phys Chem A; 2011 Sep; 115(34):9520-7. PubMed ID: 21528875
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation Regulates the Bound Structure of an Intrinsically Disordered Protein: The p53-TAZ2 Case.
    Ithuralde RE; Turjanski AG
    PLoS One; 2016; 11(1):e0144284. PubMed ID: 26742101
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy.
    Shin JS; Ha JH; Chi SW
    Biochem Biophys Res Commun; 2014 Jan; 443(3):882-7. PubMed ID: 24342622
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-X(L)-binding motif.
    Xu H; Ye H; Osman NE; Sadler K; Won EY; Chi SW; Yoon HS
    Biochemistry; 2009 Dec; 48(51):12159-68. PubMed ID: 19916559
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2.
    Yadahalli S; Neira JL; Johnson CM; Tan YS; Rowling PJE; Chattopadhyay A; Verma CS; Itzhaki LS
    Sci Rep; 2019 Jan; 9(1):693. PubMed ID: 30679555
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study.
    Lee HJ; Srinivasan D; Coomber D; Lane DP; Verma CS
    Cell Cycle; 2007 Nov; 6(21):2604-11. PubMed ID: 17957142
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular mechanism of the interaction between MDM2 and p53.
    Schon O; Friedler A; Bycroft M; Freund SM; Fersht AR
    J Mol Biol; 2002 Oct; 323(3):491-501. PubMed ID: 12381304
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo.
    Shimizu H; Burch LR; Smith AJ; Dornan D; Wallace M; Ball KL; Hupp TR
    J Biol Chem; 2002 Aug; 277(32):28446-58. PubMed ID: 11925449
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis.
    Fraser JA; Worrall EG; Lin Y; Landre V; Pettersson S; Blackburn E; Walkinshaw M; Muller P; Vojtesek B; Ball K; Hupp TR
    J Mol Biol; 2015 Apr; 427(8):1728-47. PubMed ID: 25543083
    [TBL] [Abstract][Full Text] [Related]  

  • 19. NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain.
    Vise PD; Baral B; Latos AJ; Daughdrill GW
    Nucleic Acids Res; 2005; 33(7):2061-77. PubMed ID: 15824059
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The MDMX acidic domain competes with the p53 transactivation domain for MDM2 N-terminal domain binding.
    Song Q; Liu XQ; Rainey JK
    Biochim Biophys Acta Mol Cell Res; 2022 Oct; 1869(10):119319. PubMed ID: 35780910
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.