BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 23612964)

  • 1. Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants.
    Fan YX; Wong L; Marino MP; Ou W; Shen Y; Wu WJ; Wong KK; Reiser J; Johnson GR
    J Biol Chem; 2013 Jun; 288(23):16895-16904. PubMed ID: 23612964
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites.
    Fan YX; Wong L; Deb TB; Johnson GR
    J Biol Chem; 2004 Sep; 279(37):38143-50. PubMed ID: 15231819
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.
    Yamasaki S; Nishida K; Yoshida Y; Itoh M; Hibi M; Hirano T
    Oncogene; 2003 Mar; 22(10):1546-56. PubMed ID: 12629518
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations.
    Furcht CM; Muñoz Rojas AR; Nihalani D; Lazzara MJ
    Oncogene; 2013 May; 32(18):2346-55, 2355.e1-10. PubMed ID: 22777356
    [TBL] [Abstract][Full Text] [Related]  

  • 5. SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.
    Schneeberger VE; Luetteke N; Ren Y; Berns H; Chen L; Foroutan P; Martinez GV; Haura EB; Chen J; Coppola D; Wu J
    Carcinogenesis; 2014 Aug; 35(8):1717-25. PubMed ID: 24480804
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells.
    Kapoor GS; Zhan Y; Johnson GR; O'Rourke DM
    Mol Cell Biol; 2004 Jan; 24(2):823-36. PubMed ID: 14701753
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.
    Zhang SQ; Tsiaras WG; Araki T; Wen G; Minichiello L; Klein R; Neel BG
    Mol Cell Biol; 2002 Jun; 22(12):4062-72. PubMed ID: 12024020
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling.
    Rodrigues GA; Falasca M; Zhang Z; Ong SH; Schlessinger J
    Mol Cell Biol; 2000 Feb; 20(4):1448-59. PubMed ID: 10648629
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1.
    Sithanandam G; Smith GT; Fields JR; Fornwald LW; Anderson LM
    Am J Respir Cell Mol Biol; 2005 Nov; 33(5):490-9. PubMed ID: 16055672
    [TBL] [Abstract][Full Text] [Related]  

  • 10. EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR.
    Furcht CM; Buonato JM; Lazzara MJ
    Sci Signal; 2015 May; 8(376):ra46. PubMed ID: 25969544
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation.
    Holgado-Madruga M; Wong AJ
    Cancer Res; 2004 Mar; 64(6):2007-15. PubMed ID: 15026337
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Signal strength dictates phosphoinositide 3-kinase contribution to Ras/extracellular signal-regulated kinase 1 and 2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to epidermal growth factor receptor inhibition.
    Sampaio C; Dance M; Montagner A; Edouard T; Malet N; Perret B; Yart A; Salles JP; Raynal P
    Mol Cell Biol; 2008 Jan; 28(2):587-600. PubMed ID: 18025104
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.
    Edouard T; Combier JP; Nédélec A; Bel-Vialar S; Métrich M; Conte-Auriol F; Lyonnet S; Parfait B; Tauber M; Salles JP; Lezoualc'h F; Yart A; Raynal P
    Mol Cell Biol; 2010 May; 30(10):2498-507. PubMed ID: 20308328
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown.
    Srikar R; Suresh D; Zambre A; Taylor K; Chapman S; Leevy M; Upendran A; Kannan R
    Sci Rep; 2016 Aug; 6():30245. PubMed ID: 27530552
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification.
    Tanizaki J; Okamoto I; Fumita S; Okamoto W; Nishio K; Nakagawa K
    Oncogene; 2011 Sep; 30(39):4097-106. PubMed ID: 21499301
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor.
    Cunnick JM; Dorsey JF; Munoz-Antonia T; Mei L; Wu J
    J Biol Chem; 2000 May; 275(18):13842-8. PubMed ID: 10788507
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.
    Schneeberger VE; Ren Y; Luetteke N; Huang Q; Chen L; Lawrence HR; Lawrence NJ; Haura EB; Koomen JM; Coppola D; Wu J
    Oncotarget; 2015 Mar; 6(8):6191-202. PubMed ID: 25730908
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modulation of ErbB2 blockade in ErbB2-positive cancers: the role of ErbB2 Mutations and PHLDA1.
    Li G; Wang X; Hibshoosh H; Jin C; Halmos B
    PLoS One; 2014; 9(9):e106349. PubMed ID: 25238247
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A role for Grb2-associated binder-1 in growth hormone signaling.
    Kim SO; Loesch K; Wang X; Jiang J; Mei L; Cunnick JM; Wu J; Frank SJ
    Endocrinology; 2002 Dec; 143(12):4856-67. PubMed ID: 12446613
    [TBL] [Abstract][Full Text] [Related]  

  • 20. EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.
    Trowe T; Boukouvala S; Calkins K; Cutler RE; Fong R; Funke R; Gendreau SB; Kim YD; Miller N; Woolfrey JR; Vysotskaia V; Yang JP; Gerritsen ME; Matthews DJ; Lamb P; Heuer TS
    Clin Cancer Res; 2008 Apr; 14(8):2465-75. PubMed ID: 18413839
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.