BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 23623492)

  • 1. Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
    Zhou L; Amblard F; Zhang H; McBrayer TR; Detorio MA; Whitaker T; Coats SJ; Schinazi RF
    Bioorg Med Chem Lett; 2013 Jun; 23(11):3385-8. PubMed ID: 23623492
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
    Mish MR; Cho A; Kirschberg T; Xu J; Zonte CS; Fenaux M; Park Y; Babusis D; Feng JY; Ray AS; Kim CU
    Bioorg Med Chem Lett; 2014 Jul; 24(14):3092-5. PubMed ID: 24907145
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
    Chang W; Du J; Rachakonda S; Ross BS; Convers-Reignier S; Yau WT; Pons JF; Murakami E; Bao H; Steuer HM; Furman PA; Otto MJ; Sofia MJ
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4539-43. PubMed ID: 20580554
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue.
    Hu W; Wang P; Song C; Pan Z; Wang Q; Guo X; Yu X; Shen Z; Wang S; Chang J
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7297-8. PubMed ID: 21106452
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
    Di Francesco ME; Avolio S; Pompei M; Pesci S; Monteagudo E; Pucci V; Giuliano C; Fiore F; Rowley M; Summa V
    Bioorg Med Chem; 2012 Aug; 20(15):4801-11. PubMed ID: 22770556
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
    Stammers TA; Coulombe R; Rancourt J; Thavonekham B; Fazal G; Goulet S; Jakalian A; Wernic D; Tsantrizos Y; Poupart MA; Bös M; McKercher G; Thauvette L; Kukolj G; Beaulieu PL
    Bioorg Med Chem Lett; 2013 May; 23(9):2585-9. PubMed ID: 23545108
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.
    Canales E; Carlson JS; Appleby T; Fenaux M; Lee J; Tian Y; Tirunagari N; Wong M; Watkins WJ
    Bioorg Med Chem Lett; 2012 Jul; 22(13):4288-92. PubMed ID: 22664130
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors.
    Zlatev I; Dutartre H; Barvik I; Neyts J; Canard B; Vasseur JJ; Alvarez K; Morvan F
    J Med Chem; 2008 Sep; 51(18):5745-57. PubMed ID: 18800766
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and antiviral properties of novel tetracyclic nucleoside inhibitors of hepatitis C NS5B polymerase.
    Di Francesco ME; Avolio S; Dessole G; Koch U; Pompei M; Pucci V; Rowley M; Summa V
    Nucleosides Nucleotides Nucleic Acids; 2012; 31(8):592-607. PubMed ID: 22908950
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
    Stammers TA; Coulombe R; Duplessis M; Fazal G; Gagnon A; Garneau M; Goulet S; Jakalian A; LaPlante S; Rancourt J; Thavonekham B; Wernic D; Kukolj G; Beaulieu PL
    Bioorg Med Chem Lett; 2013 Dec; 23(24):6879-85. PubMed ID: 24176401
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
    McGowan D; Vendeville S; Lin TI; Tahri A; Hu L; Cummings MD; Amssoms K; Berke JM; Canard M; Cleiren E; Dehertogh P; Last S; Fransen E; Van Der Helm E; Van den Steen I; Vijgen L; Rouan MC; Fanning G; Nyanguile O; Van Emelen K; Simmen K; Raboisson P
    Bioorg Med Chem Lett; 2012 Jul; 22(13):4431-6. PubMed ID: 22542193
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
    Manfroni G; Meschini F; Barreca ML; Leyssen P; Samuele A; Iraci N; Sabatini S; Massari S; Maga G; Neyts J; Cecchetti V
    Bioorg Med Chem; 2012 Jan; 20(2):866-76. PubMed ID: 22197397
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Studying HCV RNA synthesis in vitro with replication complexes.
    Yang W; Huang M
    Methods Mol Biol; 2009; 510():177-84. PubMed ID: 19009261
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.
    Chan L; Das SK; Reddy TJ; Poisson C; Proulx M; Pereira O; Courchesne M; Roy C; Wang W; Siddiqui A; Yannopoulos CG; Nguyen-Ba N; Labrecque D; Bethell R; Hamel M; Courtemanche-Asselin P; L'Heureux L; David M; Nicolas O; Brunette S; Bilimoria D; Bédard J
    Bioorg Med Chem Lett; 2004 Feb; 14(3):793-6. PubMed ID: 14741291
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
    Hendricks RT; Fell JB; Blake JF; Fischer JP; Robinson JE; Spencer SR; Stengel PJ; Bernacki AL; Leveque VJ; Le Pogam S; Rajyaguru S; Najera I; Josey JA; Harris JR; Swallow S
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3637-41. PubMed ID: 19447623
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Nucleoside analog inhibitors of hepatitis C virus replication.
    Carroll SS; Olsen DB
    Infect Disord Drug Targets; 2006 Mar; 6(1):17-29. PubMed ID: 16787301
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
    Donner PL; Xie Q; Pratt JK; Maring CJ; Kati W; Jiang W; Liu Y; Koev G; Masse S; Montgomery D; Molla A; Kempf DJ
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2735-8. PubMed ID: 18362072
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
    Pacini B; Avolio S; Ercolani C; Koch U; Migliaccio G; Narjes F; Pacini L; Tomei L; Harper S
    Bioorg Med Chem Lett; 2009 Nov; 19(21):6245-9. PubMed ID: 19800789
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.
    Reddy TJ; Chan L; Turcotte N; Proulx M; Pereira OZ; Das SK; Siddiqui A; Wang W; Poisson C; Yannopoulos CG; Bilimoria D; L'Heureux L; Alaoui HM; Nguyen-Ba N
    Bioorg Med Chem Lett; 2003 Oct; 13(19):3341-4. PubMed ID: 12951122
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibitors of the HCV NS5B polymerase: new hope for the treatment of hepatitis C infections.
    Beaulieu PL; Tsantrizos YS
    Curr Opin Investig Drugs; 2004 Aug; 5(8):838-50. PubMed ID: 15600240
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.