These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

150 related articles for article (PubMed ID: 23627297)

  • 21. Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease.
    Tarazi H; Odeh RA; Al-Qawasmeh R; Yousef IA; Voelter W; Al-Tel TH
    Eur J Med Chem; 2017 Jan; 125():1213-1224. PubMed ID: 27871037
    [TBL] [Abstract][Full Text] [Related]  

  • 22. A physicochemical descriptor based method for effective and rapid screening of dual inhibitors against BACE-1 and GSK-3β as targets for Alzheimer's disease.
    Kumar A; Srivastava G; Sharma A
    Comput Biol Chem; 2017 Dec; 71():1-9. PubMed ID: 28950235
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
    Thompson LA; Shi J; Decicco CP; Tebben AJ; Olson RE; Boy KM; Guernon JM; Good AC; Liauw A; Zheng C; Copeland RA; Combs AP; Trainor GL; Camac DM; Muckelbauer JK; Lentz KA; Grace JE; Burton CR; Toyn JH; Barten DM; Marcinkeviciene J; Meredith JE; Albright CF; Macor JE
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6909-15. PubMed ID: 21974952
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Progress toward the discovery and development of efficacious BACE inhibitors.
    Durham TB; Shepherd TA
    Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.
    Zhao XJ; Gong DM; Jiang YR; Guo D; Zhu Y; Deng YC
    Eur J Med Chem; 2017 Sep; 138():738-747. PubMed ID: 28728106
    [TBL] [Abstract][Full Text] [Related]  

  • 26. New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain.
    Gravenfors Y; Viklund J; Blid J; Ginman T; Karlström S; Kihlström J; Kolmodin K; Lindström J; von Berg S; von Kieseritzky F; Bogar K; Slivo C; Swahn BM; Olsson LL; Johansson P; Eketjäll S; Fälting J; Jeppsson F; Strömberg K; Janson J; Rahm F
    J Med Chem; 2012 Nov; 55(21):9297-311. PubMed ID: 23017051
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
    Taoka BM; Wu WL; Hao J; Dolmaski M; Wang H; Levorse D; Orth P; Hyde LA; Smith B; Michener MS; Kennedy ME; Parker EM; Cumming JN
    Bioorg Med Chem Lett; 2022 Jan; 56():128463. PubMed ID: 34838652
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Rational design, synthesis and in vitro evaluation of allylidene hydrazinecarboximidamide derivatives as BACE-1 inhibitors.
    Jain P; Wadhwa PK; Rohilla S; Jadhav HR
    Bioorg Med Chem Lett; 2016 Jan; 26(1):33-7. PubMed ID: 26614409
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Semi-synthetic isoflavones as BACE-1 inhibitors against Alzheimer's disease.
    Ribaudo G; Coghi P; Zanforlin E; Law BYK; Wu YYJ; Han Y; Qiu AC; Qu YQ; Zagotto G; Wong VKW
    Bioorg Chem; 2019 Jun; 87():474-483. PubMed ID: 30927588
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Potency prediction of β-secretase (BACE-1) inhibitors using density functional methods.
    Roos K; Viklund J; Meuller J; Kaspersson K; Svensson M
    J Chem Inf Model; 2014 Mar; 54(3):818-25. PubMed ID: 24456077
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
    Hanessian S; Shao Z; Betschart C; Rondeau JM; Neumann U; Tintelnot-Blomley M
    Bioorg Med Chem Lett; 2010 Mar; 20(6):1924-7. PubMed ID: 20172717
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
    Wångsell F; Gustafsson K; Kvarnström I; Borkakoti N; Edlund M; Jansson K; Lindberg J; Hallberg A; Rosenquist A; Samuelsson B
    Eur J Med Chem; 2010 Mar; 45(3):870-82. PubMed ID: 20036448
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Review of synthesis, biological assay and QSAR studies of β-secretase inhibitors.
    Niño H; García-Pintos I; Rodríguez-Borges JE; Escobar-Cubiella M; García-Mera X; Prado-Prado F
    Curr Comput Aided Drug Des; 2011 Dec; 7(4):263-75. PubMed ID: 22050682
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design and synthesis of statine-containing BACE inhibitors.
    Hu J; Cwi CL; Smiley DL; Timm D; Erickson JA; McGee JE; Yang HC; Mendel D; May PC; Shapiro M; McCarthy JR
    Bioorg Med Chem Lett; 2003 Dec; 13(24):4335-9. PubMed ID: 14643321
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
    Bowers S; Xu YZ; Yuan S; Probst GD; Hom RK; Chan W; Konradi AW; Sham HL; Zhu YL; Beroza P; Pan H; Brecht E; Yao N; Lougheed J; Tam D; Ren Z; Ruslim L; Bova MP; Artis DR
    Bioorg Med Chem Lett; 2013 Apr; 23(7):2181-6. PubMed ID: 23465612
    [TBL] [Abstract][Full Text] [Related]  

  • 36. 3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors.
    Peschiulli A; Oehlrich D; Rombouts F; Vos A; Gijsen HJ
    Bioorg Med Chem Lett; 2020 Apr; 30(8):126999. PubMed ID: 32089426
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
    Geschwindner S; Olsson LL; Albert JS; Deinum J; Edwards PD; de Beer T; Folmer RH
    J Med Chem; 2007 Nov; 50(24):5903-11. PubMed ID: 17985861
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.
    Shimmyo Y; Kihara T; Akaike A; Niidome T; Sugimoto H
    Biochim Biophys Acta; 2008 May; 1780(5):819-25. PubMed ID: 18295609
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.
    Veenstra SJ; Rueeger H; Voegtle M; Lueoend R; Holzer P; Hurth K; Tintelnot-Blomley M; Frederiksen M; Rondeau JM; Jacobson L; Staufenbiel M; Neumann U; Machauer R
    Bioorg Med Chem Lett; 2018 Jul; 28(12):2195-2200. PubMed ID: 29764741
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.