BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

316 related articles for article (PubMed ID: 23629654)

  • 1. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
    Krishnamoorthy GP; Guida T; Alfano L; Avilla E; Santoro M; Carlomagno F; Melillo RM
    J Biol Chem; 2013 Jun; 288(24):17481-94. PubMed ID: 23629654
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ErbB2 degradation mediated by the co-chaperone protein CHIP.
    Zhou P; Fernandes N; Dodge IL; Reddi AL; Rao N; Safran H; DiPetrillo TA; Wazer DE; Band V; Band H
    J Biol Chem; 2003 Apr; 278(16):13829-37. PubMed ID: 12574167
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein.
    Bonvini P; Dalla Rosa H; Vignes N; Rosolen A
    Cancer Res; 2004 May; 64(9):3256-64. PubMed ID: 15126367
    [TBL] [Abstract][Full Text] [Related]  

  • 4. RET is a heat shock protein 90 (HSP90) client protein and is knocked down upon HSP90 pharmacological block.
    Alfano L; Guida T; Provitera L; Vecchio G; Billaud M; Santoro M; Carlomagno F
    J Clin Endocrinol Metab; 2010 Jul; 95(7):3552-7. PubMed ID: 20444924
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery.
    Ding G; Chen P; Zhang H; Huang X; Zang Y; Li J; Li J; Wong J
    J Biol Chem; 2016 Sep; 291(38):20125-35. PubMed ID: 27489107
    [TBL] [Abstract][Full Text] [Related]  

  • 6. FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.
    Yao Q; Nishiuchi R; Li Q; Kumar AR; Hudson WA; Kersey JH
    Clin Cancer Res; 2003 Oct; 9(12):4483-93. PubMed ID: 14555522
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.
    Bonvini P; Gastaldi T; Falini B; Rosolen A
    Cancer Res; 2002 Mar; 62(5):1559-66. PubMed ID: 11888936
    [TBL] [Abstract][Full Text] [Related]  

  • 8. MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer.
    Wang W; Zhao J; Wen X; Lin CC; Li J; Huang Q; Yu Y; Lin SY; Li C
    Contrast Media Mol Imaging; 2017; 2017():1686525. PubMed ID: 29097911
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells.
    Khattar V; Fried J; Xu B; Thottassery JV
    Cancer Chemother Pharmacol; 2015 Feb; 75(2):411-20. PubMed ID: 25544127
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
    Ou WB; Hubert C; Corson JM; Bueno R; Flynn DL; Sugarbaker DJ; Fletcher JA
    Neoplasia; 2011 Jan; 13(1):12-22. PubMed ID: 21245936
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression.
    Georgakis GV; Li Y; Rassidakis GZ; Medeiros LJ; Younes A
    Exp Hematol; 2006 Dec; 34(12):1670-9. PubMed ID: 17157164
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors.
    Wang S; Pashtan I; Tsutsumi S; Xu W; Neckers L
    Cell Cycle; 2009 Jul; 8(13):2050-6. PubMed ID: 19502802
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphorylation accelerates geldanamycin-induced Akt degradation.
    Su CH; Lan KH; Li CP; Chao Y; Lin HC; Lee SD; Lee WP
    Arch Biochem Biophys; 2013 Aug; 536(1):6-11. PubMed ID: 23668972
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP.
    Faresse N; Ruffieux-Daidie D; Salamin M; Gomez-Sanchez CE; Staub O
    Am J Physiol Renal Physiol; 2010 Dec; 299(6):F1462-72. PubMed ID: 20861078
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.
    George P; Bali P; Cohen P; Tao J; Guo F; Sigua C; Vishvanath A; Fiskus W; Scuto A; Annavarapu S; Moscinski L; Bhalla K
    Cancer Res; 2004 May; 64(10):3645-52. PubMed ID: 15150124
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
    Khaledian B; Taguchi A; Shin-Ya K; Kondo-Ida L; Kagaya N; Suzuki M; Kajino T; Yamaguchi T; Shimada Y; Takahashi T
    Cancer Sci; 2021 Mar; 112(3):1225-1234. PubMed ID: 33370472
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Protein kinase C mediated internalization of ErbB2 is independent of clathrin, ubiquitination and Hsp90 dissociation.
    Dietrich M; Malik MS; Nikolaysen F; Skeie M; Stang E
    Exp Cell Res; 2018 Oct; 371(1):139-150. PubMed ID: 30098331
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV; Li Y; Rassidakis GZ; Martinez-Valdez H; Medeiros LJ; Younes A
    Clin Cancer Res; 2006 Jan; 12(2):584-90. PubMed ID: 16428504
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
    Kang SA; Cho HS; Yoon JB; Chung IK; Lee ST
    Biochem J; 2012 Oct; 447(2):313-20. PubMed ID: 22849407
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
    Holmes JL; Sharp SY; Hobbs S; Workman P
    Cancer Res; 2008 Feb; 68(4):1188-97. PubMed ID: 18281495
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.