These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
128 related articles for article (PubMed ID: 2363122)
1. Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin. Krstenansky JL; Broersma RJ; Owen TJ; Payne MH; Yates MT; Mao SJ Thromb Haemost; 1990 Apr; 63(2):208-14. PubMed ID: 2363122 [TBL] [Abstract][Full Text] [Related]
2. Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II. Monteiro RQ; Rapôso JG; Wisner A; Guimarães JA; Bon C; Zingali RB Biochem Biophys Res Commun; 1999 Sep; 262(3):819-22. PubMed ID: 10471408 [TBL] [Abstract][Full Text] [Related]
3. Probing the distance between the two binding sites of hirudin for its interaction with the active site and the fibrin(ogen)-binding site of alpha-thrombin. Wagner U; Schmitz T; Otte M; Dodt J Biomed Biochim Acta; 1991; 50(4-6):707-10. PubMed ID: 1801747 [TBL] [Abstract][Full Text] [Related]
4. Hirudins: from leeches to man. Wallis RB Semin Thromb Hemost; 1996; 22(2):185-96. PubMed ID: 8807716 [TBL] [Abstract][Full Text] [Related]
5. Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors. Lombardi A; Nastri F; Della Morte R; Rossi A; De Rosa A; Staiano N; Pedone C; Pavone V J Med Chem; 1996 May; 39(10):2008-17. PubMed ID: 8642559 [TBL] [Abstract][Full Text] [Related]
6. Hirudin as alternative anticoagulant--a historical review. Markwardt F Semin Thromb Hemost; 2002 Oct; 28(5):405-14. PubMed ID: 12420235 [TBL] [Abstract][Full Text] [Related]
7. The C-terminal binding domain of hirullin P18. Antithrombin activity and comparison to hirudin peptides. Krstenansky JL; Owen TJ; Yates MT; Mao SJ FEBS Lett; 1990 Sep; 269(2):425-9. PubMed ID: 2401369 [TBL] [Abstract][Full Text] [Related]
8. Comparison of hirudin and hirudin PA C-terminal fragments and related analogs as antithrombin agents. Krstenansky JL; Owen TJ; Yates MT; Mao SJ Thromb Res; 1988 Oct; 52(2):137-41. PubMed ID: 3194888 [TBL] [Abstract][Full Text] [Related]
9. [Recent developments in the biochemistry of hirudins]. Walsmann P Folia Haematol Int Mag Klin Morphol Blutforsch; 1989; 116(6):821-30. PubMed ID: 2483699 [TBL] [Abstract][Full Text] [Related]
10. A screening procedure to evaluate the anticoagulant activity and the kinetic behaviour of direct thrombin inhibitors. Rupin A; Mennecier P; de Nanteuil G; Laubie M; Verbeuren TJ Thromb Res; 1995 May; 78(3):217-25. PubMed ID: 7631302 [TBL] [Abstract][Full Text] [Related]
11. Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I. Myles T; Le Bonniec BF; Betz A; Stone SR Biochemistry; 2001 Apr; 40(16):4972-9. PubMed ID: 11305913 [TBL] [Abstract][Full Text] [Related]
12. Covalent linkage of streptokinase to recombinant hirudin: a novel thrombolytic agent with antithrombotic properties. Phaneuf MD; Ozaki CK; Johnstone MT; Loza JP; Quist WC; LoGerfo FW Thromb Haemost; 1994 Apr; 71(4):481-7. PubMed ID: 8052967 [TBL] [Abstract][Full Text] [Related]
13. Effect of new synthetic heparin mimetics on whole blood thrombin generation in vivo and in vitro in rats. Hérault JP; Bernat A; Gaich C; Herbert M Thromb Haemost; 2002 Feb; 87(2):238-44. PubMed ID: 11858483 [TBL] [Abstract][Full Text] [Related]
15. Hirudin for diagnostic purposes. Stocker K Haemostasis; 1991; 21 Suppl 1():161-7. PubMed ID: 1894191 [TBL] [Abstract][Full Text] [Related]
16. Comparative pharmacology of site directed antithrombin agents. Implication in drug development. Callas D; Fareed J Thromb Haemost; 1995 Jul; 74(1):473-81. PubMed ID: 8578509 [TBL] [Abstract][Full Text] [Related]
17. Inhibition of extrinsic and intrinsic thrombin generation by a novel synthetic thrombin inhibitor (Ro 46-6240), recombinant hirudin and heparin in human plasma. Gast A; Tschopp TB Blood Coagul Fibrinolysis; 1995 Sep; 6(6):553-60. PubMed ID: 7578898 [TBL] [Abstract][Full Text] [Related]
18. Interaction of hirudin with thrombin: identification of a minimal binding domain of hirudin that inhibits clotting activity. Mao SJ; Yates MT; Owen TJ; Krstenansky JL Biochemistry; 1988 Oct; 27(21):8170-3. PubMed ID: 3233202 [TBL] [Abstract][Full Text] [Related]
19. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study. Nardini M; Pesce A; Rizzi M; Casale E; Ferraccioli R; Balliano G; Milla P; Ascenzi P; Bolognesi M J Mol Biol; 1996 May; 258(5):851-9. PubMed ID: 8637015 [TBL] [Abstract][Full Text] [Related]
20. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]