BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

302 related articles for article (PubMed ID: 23647983)

  • 1. Allosteric inhibition of HIV-1 integrase activity.
    Engelman A; Kessl JJ; Kvaratskhelia M
    Curr Opin Chem Biol; 2013 Jun; 17(3):339-45. PubMed ID: 23647983
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
    Feng L; Dharmarajan V; Serrao E; Hoyte A; Larue RC; Slaughter A; Sharma A; Plumb MR; Kessl JJ; Fuchs JR; Bushman FD; Engelman AN; Griffin PR; Kvaratskhelia M
    ACS Chem Biol; 2016 May; 11(5):1313-21. PubMed ID: 26910179
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
    Feng L; Sharma A; Slaughter A; Jena N; Koh Y; Shkriabai N; Larue RC; Patel PA; Mitsuya H; Kessl JJ; Engelman A; Fuchs JR; Kvaratskhelia M
    J Biol Chem; 2013 May; 288(22):15813-20. PubMed ID: 23615903
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
    Jurado KA; Wang H; Slaughter A; Feng L; Kessl JJ; Koh Y; Wang W; Ballandras-Colas A; Patel PA; Fuchs JR; Kvaratskhelia M; Engelman A
    Proc Natl Acad Sci U S A; 2013 May; 110(21):8690-5. PubMed ID: 23610442
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.
    Christ F; Shaw S; Demeulemeester J; Desimmie BA; Marchand A; Butler S; Smets W; Chaltin P; Westby M; Debyser Z; Pickford C
    Antimicrob Agents Chemother; 2012 Aug; 56(8):4365-74. PubMed ID: 22664975
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.
    Engelman AN
    J Biol Chem; 2019 Oct; 294(41):15137-15157. PubMed ID: 31467082
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
    Patel D; Antwi J; Koneru PC; Serrao E; Forli S; Kessl JJ; Feng L; Deng N; Levy RM; Fuchs JR; Olson AJ; Engelman AN; Bauman JD; Kvaratskhelia M; Arnold E
    J Biol Chem; 2016 Nov; 291(45):23569-23577. PubMed ID: 27645997
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.
    Jurado KA; Engelman A
    Expert Rev Mol Med; 2013 Nov; 15():e14. PubMed ID: 24274067
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular modeling study on the allosteric inhibition mechanism of HIV-1 integrase by LEDGF/p75 binding site inhibitors.
    Xue W; Liu H; Yao X
    PLoS One; 2014; 9(3):e90799. PubMed ID: 24599328
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Quinoline-based Protein-protein Interaction Inhibitors of LEDGF/p75 and HIV Integrase: An In Silico Study.
    Chhokar N; Kalra S; Chauhan M; Munshi A; Kumar R
    Curr Top Med Chem; 2018; 18(32):2800-2815. PubMed ID: 30747071
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
    Le Rouzic E; Bonnard D; Chasset S; Bruneau JM; Chevreuil F; Le Strat F; Nguyen J; Beauvoir R; Amadori C; Brias J; Vomscheid S; Eiler S; Lévy N; Delelis O; Deprez E; Saïb A; Zamborlini A; Emiliani S; Ruff M; Ledoussal B; Moreau F; Benarous R
    Retrovirology; 2013 Nov; 10():144. PubMed ID: 24261564
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer.
    Sun J; Patel K; Hume J; Pigza JA; Donahue MG; Kessl JJ
    J Biol Chem; 2021; 296():100363. PubMed ID: 33539919
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
    Koneru PC; Francis AC; Deng N; Rebensburg SV; Hoyte AC; Lindenberger J; Adu-Ampratwum D; Larue RC; Wempe MF; Engelman AN; Lyumkis D; Fuchs JR; Levy RM; Melikyan GB; Kvaratskhelia M
    Elife; 2019 May; 8():. PubMed ID: 31120420
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome.
    van Bel N; van der Velden Y; Bonnard D; Le Rouzic E; Das AT; Benarous R; Berkhout B
    PLoS One; 2014; 9(7):e103552. PubMed ID: 25072705
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors.
    Singh PK; Li W; Bedwell GJ; Fadel HJ; Poeschla EM; Engelman AN
    Viruses; 2022 Aug; 14(9):. PubMed ID: 36146690
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.
    Christ F; Debyser Z
    Virology; 2013 Jan; 435(1):102-9. PubMed ID: 23217620
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate.
    Savarino A
    Retrovirology; 2007 Mar; 4():21. PubMed ID: 17374162
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
    Bonnard D; Le Rouzic E; Eiler S; Amadori C; Orlov I; Bruneau JM; Brias J; Barbion J; Chevreuil F; Spehner D; Chasset S; Ledoussal B; Moreau F; Saïb A; Klaholz BP; Emiliani S; Ruff M; Zamborlini A; Benarous R
    J Biol Chem; 2018 Apr; 293(16):6172-6186. PubMed ID: 29507092
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
    Shkriabai N; Dharmarajan V; Slaughter A; Kessl JJ; Larue RC; Feng L; Fuchs JR; Griffin PR; Kvaratskhelia M
    J Biol Chem; 2014 Sep; 289(38):26430-26440. PubMed ID: 25118283
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A new class of multimerization selective inhibitors of HIV-1 integrase.
    Sharma A; Slaughter A; Jena N; Feng L; Kessl JJ; Fadel HJ; Malani N; Male F; Wu L; Poeschla E; Bushman FD; Fuchs JR; Kvaratskhelia M
    PLoS Pathog; 2014 May; 10(5):e1004171. PubMed ID: 24874515
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.