These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

169 related articles for article (PubMed ID: 23651437)

  • 1. Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists.
    Kormos CM; Jin C; Cueva JP; Runyon SP; Thomas JB; Brieaddy LE; Mascarella SW; Navarro HA; Gilmour BP; Carroll FI
    J Med Chem; 2013 Jun; 56(11):4551-67. PubMed ID: 23651437
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors.
    Zaveri NT; Journigan VB; Polgar WE
    ACS Chem Neurosci; 2015 Apr; 6(4):646-57. PubMed ID: 25635572
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.
    Thomas JB; Atkinson RN; Vinson NA; Catanzaro JL; Perretta CL; Fix SE; Mascarella SW; Rothman RB; Xu H; Dersch CM; Cantrell BE; Zimmerman DM; Carroll FI
    J Med Chem; 2003 Jul; 46(14):3127-37. PubMed ID: 12825951
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity.
    Runyon SP; Brieaddy LE; Mascarella SW; Thomas JB; Navarro HA; Howard JL; Pollard GT; Carroll FI
    J Med Chem; 2010 Jul; 53(14):5290-301. PubMed ID: 20568781
    [TBL] [Abstract][Full Text] [Related]  

  • 5. High-affinity carbamate analogues of morphinan at opioid receptors.
    Peng X; Knapp BI; Bidlack JM; Neumeyer JL
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1508-11. PubMed ID: 17276685
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
    Cai TB; Zou Z; Thomas JB; Brieaddy L; Navarro HA; Carroll FI
    J Med Chem; 2008 Mar; 51(6):1849-60. PubMed ID: 18307295
    [TBL] [Abstract][Full Text] [Related]  

  • 7. N-substituted 4beta-methyl-5-(3-hydroxyphenyl)-7alpha-amidomorphans are potent, selective kappa opioid receptor antagonists.
    Carroll FI; Melvin MS; Nuckols MC; Mascarella SW; Navarro HA; Thomas JB
    J Med Chem; 2006 Mar; 49(5):1781-91. PubMed ID: 16509593
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic).
    Kormos CM; Ondachi PW; Runyon SP; Thomas JB; Mascarella SW; Decker AM; Navarro HA; Fennell TR; Snyder RW; Carroll FI
    J Med Chem; 2018 Sep; 61(17):7546-7559. PubMed ID: 30032602
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers.
    Furness MS; Zhang X; Coop A; Jacobson AE; Rothman RB; Dersch CM; Xu H; Porreca F; Rice KC
    J Med Chem; 2000 Aug; 43(16):3193-6. PubMed ID: 10956228
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic).
    Ondachi PW; Kormos CM; Runyon SP; Thomas JB; Mascarella SW; Decker AM; Navarro HA; Fennell TR; Snyder RW; Carroll FI
    J Med Chem; 2018 Sep; 61(17):7525-7545. PubMed ID: 30117738
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide.
    Kim IJ; Ullrich T; Janetka JW; Furness MS; Jacobson AE; Rothman RB; Dersch CM; Flippen-Anderson JL; George C; Rice KC
    Bioorg Med Chem; 2003 Nov; 11(22):4761-8. PubMed ID: 14556791
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
    Kormos CM; Gichinga MG; Maitra R; Runyon SP; Thomas JB; Brieaddy LE; Mascarella SW; Navarro HA; Carroll FI
    J Med Chem; 2014 Sep; 57(17):7367-81. PubMed ID: 25133923
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.
    Le Bourdonnec B; Goodman AJ; Graczyk TM; Belanger S; Seida PR; DeHaven RN; Dolle RE
    J Med Chem; 2006 Dec; 49(25):7290-306. PubMed ID: 17149859
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
    McLamore S; Ullrich T; Rothman RB; Xu H; Dersch C; Coop A; Davis P; Porreca F; Jacobson AE; Rice KC
    J Med Chem; 2001 Apr; 44(9):1471-4. PubMed ID: 11311071
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer.
    Mitch CH; Quimby SJ; Diaz N; Pedregal C; de la Torre MG; Jimenez A; Shi Q; Canada EJ; Kahl SD; Statnick MA; McKinzie DL; Benesh DR; Rash KS; Barth VN
    J Med Chem; 2011 Dec; 54(23):8000-12. PubMed ID: 21958337
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
    Cueva JP; Cai TB; Mascarella SW; Thomas JB; Navarro HA; Carroll FI
    J Med Chem; 2009 Dec; 52(23):7463-72. PubMed ID: 19954245
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain.
    Sim LJ; Childers SR
    J Comp Neurol; 1997 Oct; 386(4):562-72. PubMed ID: 9378852
    [TBL] [Abstract][Full Text] [Related]  

  • 18. N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.
    Thomas JB; Zheng X; Mascarella SW; Rothman RB; Dersch CM; Partilla JS; Flippen-Anderson JL; George CF; Cantrell BE; Zimmerman DM; Carroll FI
    J Med Chem; 1998 Oct; 41(21):4143-9. PubMed ID: 9767649
    [TBL] [Abstract][Full Text] [Related]  

  • 19. N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists.
    Carroll FI; Chaudhari S; Thomas JB; Mascarella SW; Gigstad KM; Deschamps J; Navarro HA
    J Med Chem; 2005 Dec; 48(26):8182-93. PubMed ID: 16366600
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.
    Peng X; Knapp BI; Bidlack JM; Neumeyer JL
    J Med Chem; 2007 May; 50(9):2254-8. PubMed ID: 17407276
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.