183 related articles for article (PubMed ID: 23656407)
1. X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.
Elkins JM; Wang J; Deng X; Pattison MJ; Arthur JS; Erazo T; Gomez N; Lizcano JM; Gray NS; Knapp S
J Med Chem; 2013 Jun; 56(11):4413-21. PubMed ID: 23656407
[TBL] [Abstract][Full Text] [Related]
2. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.
Deng X; Elkins JM; Zhang J; Yang Q; Erazo T; Gomez N; Choi HG; Wang J; Dzamko N; Lee JD; Sim T; Kim N; Alessi DR; Lizcano JM; Knapp S; Gray NS
Eur J Med Chem; 2013; 70():758-67. PubMed ID: 24239623
[TBL] [Abstract][Full Text] [Related]
3. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
Wang J; Erazo T; Ferguson FM; Buckley DL; Gomez N; Muñoz-Guardiola P; Diéguez-Martínez N; Deng X; Hao M; Massefski W; Fedorov O; Offei-Addo NK; Park PM; Dai L; DiBona A; Becht K; Kim ND; McKeown MR; Roberts JM; Zhang J; Sim T; Alessi DR; Bradner JE; Lizcano JM; Blacklow SC; Qi J; Xu X; Gray NS
ACS Chem Biol; 2018 Sep; 13(9):2438-2448. PubMed ID: 30102854
[TBL] [Abstract][Full Text] [Related]
4. Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Chen H; Tucker J; Wang X; Gavine PR; Phillips C; Augustin MA; Schreiner P; Steinbacher S; Preston M; Ogg D
Acta Crystallogr D Struct Biol; 2016 May; 72(Pt 5):682-93. PubMed ID: 27139631
[TBL] [Abstract][Full Text] [Related]
5. Design of a dual ERK5 kinase activation and autophosphorylation inhibitor to block cancer stem cell activity.
Kedika SR; Shukla SP; Udugamasooriya DG
Bioorg Med Chem Lett; 2020 Dec; 30(23):127552. PubMed ID: 32946922
[TBL] [Abstract][Full Text] [Related]
6. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
Nguyen D; Lemos C; Wortmann L; Eis K; Holton SJ; Boemer U; Moosmayer D; Eberspaecher U; Weiske J; Lechner C; Prechtl S; Suelzle D; Siegel F; Prinz F; Lesche R; Nicke B; Nowak-Reppel K; Himmel H; Mumberg D; von Nussbaum F; Nising CF; Bauser M; Haegebarth A
J Med Chem; 2019 Jan; 62(2):928-940. PubMed ID: 30563338
[TBL] [Abstract][Full Text] [Related]
7. Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module.
Glatz G; Gógl G; Alexa A; Reményi A
J Biol Chem; 2013 Mar; 288(12):8596-8609. PubMed ID: 23382384
[TBL] [Abstract][Full Text] [Related]
8. Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.
Lochhead PA; Tucker JA; Tatum NJ; Wang J; Oxley D; Kidger AM; Johnson VP; Cassidy MA; Gray NS; Noble MEM; Cook SJ
Nat Commun; 2020 Mar; 11(1):1383. PubMed ID: 32170057
[TBL] [Abstract][Full Text] [Related]
9. EGCG Suppresses ERK5 Activation to Reverse Tobacco Smoke-Triggered Gastric Epithelial-Mesenchymal Transition in BALB/c Mice.
Lu L; Chen J; Tang H; Bai L; Lu C; Wang K; Li M; Yan Y; Tang L; Wu R; Ye Y; Jin L; Liang Z
Nutrients; 2016 Jul; 8(7):. PubMed ID: 27447666
[TBL] [Abstract][Full Text] [Related]
10. Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5).
Pearson AJ; Fullwood P; Toro Tapia G; Prise I; Smith MP; Xu Q; Jordan A; Giurisato E; Whitmarsh AJ; Francavilla C; Tournier C
Int J Mol Sci; 2020 Jan; 21(3):. PubMed ID: 32023819
[TBL] [Abstract][Full Text] [Related]
11. Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma.
Gavine PR; Wang M; Yu D; Hu E; Huang C; Xia J; Su X; Fan J; Zhang T; Ye Q; Zheng L; Zhu G; Qian Z; Luo Q; Hou YY; Ji Q
BMC Cancer; 2015 Jun; 15():454. PubMed ID: 26040563
[TBL] [Abstract][Full Text] [Related]
12. Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription.
Honda T; Obara Y; Yamauchi A; Couvillon AD; Mason JJ; Ishii K; Nakahata N
PLoS One; 2015; 10(2):e0117914. PubMed ID: 25689862
[TBL] [Abstract][Full Text] [Related]
13. Multisite phosphorylation of Erk5 in mitosis.
Díaz-Rodríguez E; Pandiella A
J Cell Sci; 2010 Sep; 123(Pt 18):3146-56. PubMed ID: 20736311
[TBL] [Abstract][Full Text] [Related]
14. ERK5: structure, regulation and function.
Nithianandarajah-Jones GN; Wilm B; Goldring CE; Müller J; Cross MJ
Cell Signal; 2012 Nov; 24(11):2187-96. PubMed ID: 22800864
[TBL] [Abstract][Full Text] [Related]
15. Pharmacological inhibition of the MEK5/ERK5 and PI3K/Akt signaling pathways synergistically reduces viability in triple-negative breast cancer.
Wright TD; Raybuck C; Bhatt A; Monlish D; Chakrabarty S; Wendekier K; Gartland N; Gupta M; Burow ME; Flaherty PT; Cavanaugh JE
J Cell Biochem; 2020 Feb; 121(2):1156-1168. PubMed ID: 31464004
[TBL] [Abstract][Full Text] [Related]
16. ERK5 kinase activity is dispensable for cellular immune response and proliferation.
Lin EC; Amantea CM; Nomanbhoy TK; Weissig H; Ishiyama J; Hu Y; Sidique S; Li B; Kozarich JW; Rosenblum JS
Proc Natl Acad Sci U S A; 2016 Oct; 113(42):11865-11870. PubMed ID: 27679845
[TBL] [Abstract][Full Text] [Related]
17. Erk5 nuclear location is independent on dual phosphorylation, and favours resistance to TRAIL-induced apoptosis.
Borges J; Pandiella A; Esparís-Ogando A
Cell Signal; 2007 Jul; 19(7):1473-87. PubMed ID: 17317102
[TBL] [Abstract][Full Text] [Related]
18. Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types.
Wang G; Zhao Y; Liu Y; Sun D; Zhen Y; Liu J; Fu L; Zhang L; Ouyang L
J Med Chem; 2020 Apr; 63(8):3976-3995. PubMed ID: 32078308
[TBL] [Abstract][Full Text] [Related]
19. Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.
Ding YH; Zhou ZW; Ha CF; Zhang XY; Pan ST; He ZX; Edelman JL; Wang D; Yang YX; Zhang X; Duan W; Yang T; Qiu JX; Zhou SF
Drug Des Devel Ther; 2015; 9():425-64. PubMed ID: 25624750
[TBL] [Abstract][Full Text] [Related]
20. ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial-mesenchymal transition.
Liang Z; Xie W; Wu R; Geng H; Zhao L; Xie C; Li X; Huang C; Zhu J; Zhu M; Zhu W; Wu J; Geng S; Zhong C
Oncotarget; 2015 Aug; 6(23):19605-18. PubMed ID: 25965818
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]