192 related articles for article (PubMed ID: 23658017)
1. "Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.
Kaan HY; Major J; Tkocz K; Kozielski F; Rosenfeld SS
J Biol Chem; 2013 Jun; 288(25):18588-98. PubMed ID: 23658017
[TBL] [Abstract][Full Text] [Related]
2. Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.
Muretta JM; Behnke-Parks WM; Major J; Petersen KJ; Goulet A; Moores CA; Thomas DD; Rosenfeld SS
J Biol Chem; 2013 Nov; 288(48):34839-49. PubMed ID: 24145034
[TBL] [Abstract][Full Text] [Related]
3. Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein.
Sheth PR; Basso A; Duca JS; Lesburg CA; Ogas P; Gray K; Nale L; Mannarino AF; Prongay AJ; Le HV
Biochemistry; 2009 Nov; 48(46):11045-55. PubMed ID: 19824700
[TBL] [Abstract][Full Text] [Related]
4. The structure of the ternary Eg5-ADP-ispinesib complex.
Talapatra SK; Schüttelkopf AW; Kozielski F
Acta Crystallogr D Biol Crystallogr; 2012 Oct; 68(Pt 10):1311-9. PubMed ID: 22993085
[TBL] [Abstract][Full Text] [Related]
5. Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
Turner J; Anderson R; Guo J; Beraud C; Fletterick R; Sakowicz R
J Biol Chem; 2001 Jul; 276(27):25496-502. PubMed ID: 11328809
[TBL] [Abstract][Full Text] [Related]
6. Mechanism of inhibition of human KSP by ispinesib.
Lad L; Luo L; Carson JD; Wood KW; Hartman JJ; Copeland RA; Sakowicz R
Biochemistry; 2008 Mar; 47(11):3576-85. PubMed ID: 18290633
[TBL] [Abstract][Full Text] [Related]
7. The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.
Muretta JM; Jun Y; Gross SP; Major J; Thomas DD; Rosenfeld SS
Proc Natl Acad Sci U S A; 2015 Dec; 112(48):E6606-13. PubMed ID: 26627252
[TBL] [Abstract][Full Text] [Related]
8. The structural basis of force generation by the mitotic motor kinesin-5.
Goulet A; Behnke-Parks WM; Sindelar CV; Major J; Rosenfeld SS; Moores CA
J Biol Chem; 2012 Dec; 287(53):44654-66. PubMed ID: 23135273
[TBL] [Abstract][Full Text] [Related]
9. An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.
Kaan HY; Ulaganathan V; Hackney DD; Kozielski F
Biochem J; 2009 Dec; 425(1):55-60. PubMed ID: 19793049
[TBL] [Abstract][Full Text] [Related]
10. Loop L5 acts as a conformational latch in the mitotic kinesin Eg5.
Behnke-Parks WM; Vendome J; Honig B; Maliga Z; Moores C; Rosenfeld SS
J Biol Chem; 2011 Feb; 286(7):5242-53. PubMed ID: 21148480
[TBL] [Abstract][Full Text] [Related]
11. A pathway of structural changes produced by monastrol binding to Eg5.
Maliga Z; Xing J; Cheung H; Juszczak LJ; Friedman JM; Rosenfeld SS
J Biol Chem; 2006 Mar; 281(12):7977-82. PubMed ID: 16434397
[TBL] [Abstract][Full Text] [Related]
12. Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.
Goulet A; Major J; Jun Y; Gross SP; Rosenfeld SS; Moores CA
Proc Natl Acad Sci U S A; 2014 Feb; 111(5):1837-42. PubMed ID: 24449904
[TBL] [Abstract][Full Text] [Related]
13. Inhibitor library screening identifies ispinesib as a new potential chemotherapeutic agent for pancreatic cancers.
Murase Y; Ono H; Ogawa K; Yoshioka R; Ishikawa Y; Ueda H; Akahoshi K; Ban D; Kudo A; Tanaka S; Tanabe M
Cancer Sci; 2021 Nov; 112(11):4641-4654. PubMed ID: 34510663
[TBL] [Abstract][Full Text] [Related]
14. Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
Brier S; Lemaire D; Debonis S; Forest E; Kozielski F
Biochemistry; 2004 Oct; 43(41):13072-82. PubMed ID: 15476401
[TBL] [Abstract][Full Text] [Related]
15. Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop.
Ishikawa K; Tamura Y; Maruta S
J Biochem; 2014 Mar; 155(3):195-206. PubMed ID: 24334276
[TBL] [Abstract][Full Text] [Related]
16. The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5.
Larson AG; Naber N; Cooke R; Pate E; Rice SE
Biophys J; 2010 Jun; 98(11):2619-27. PubMed ID: 20513406
[TBL] [Abstract][Full Text] [Related]
17. Structural basis of new allosteric inhibition in Kinesin spindle protein Eg5.
Yokoyama H; Sawada J; Katoh S; Matsuno K; Ogo N; Ishikawa Y; Hashimoto H; Fujii S; Asai A
ACS Chem Biol; 2015 Apr; 10(4):1128-36. PubMed ID: 25622007
[TBL] [Abstract][Full Text] [Related]
18. Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation.
Sun L; Sun X; Xie S; Yu H; Zhong D
Biochem Biophys Res Commun; 2014 May; 447(3):465-70. PubMed ID: 24732354
[TBL] [Abstract][Full Text] [Related]
19. Docking and rolling, a model of how the mitotic motor Eg5 works.
Rosenfeld SS; Xing J; Jefferson GM; King PH
J Biol Chem; 2005 Oct; 280(42):35684-95. PubMed ID: 16115880
[TBL] [Abstract][Full Text] [Related]
20. Structural insights into a unique inhibitor binding pocket in kinesin spindle protein.
Ulaganathan V; Talapatra SK; Rath O; Pannifer A; Hackney DD; Kozielski F
J Am Chem Soc; 2013 Feb; 135(6):2263-72. PubMed ID: 23305346
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
