BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

259 related articles for article (PubMed ID: 23696637)

  • 1. CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.
    Javadi M; Richmond TD; Huang K; Barber DL
    J Biol Chem; 2013 Jul; 288(27):19459-70. PubMed ID: 23696637
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of SRC corrects GM-CSF hypersensitivity that underlies juvenile myelomonocytic leukemia.
    Bunda S; Kang MW; Sybingco SS; Weng J; Favre H; Shin DH; Irwin MS; Loh ML; Ohh M
    Cancer Res; 2013 Apr; 73(8):2540-50. PubMed ID: 23400592
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via the Lyn-PI3K/AKT pathway.
    Bunda S; Qin K; Kommaraju K; Heir P; Ohh M
    Oncogene; 2015 Feb; 34(6):789-97. PubMed ID: 24469048
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.
    Duyvestyn JM; Taylor SJ; Dagger SA; Orandle M; Morse HC; Thien CB; Langdon WY
    PLoS One; 2014; 9(4):e94717. PubMed ID: 24718698
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis.
    Dahl ME; Arai KI; Watanabe S
    Genes Cells; 2000 Feb; 5(2):143-53. PubMed ID: 10672044
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.
    Nagao T; Kurosu T; Umezawa Y; Nogami A; Oshikawa G; Tohda S; Yamamoto M; Miura O
    PLoS One; 2014; 9(1):e84746. PubMed ID: 24404189
    [TBL] [Abstract][Full Text] [Related]  

  • 7. CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors.
    Makishima H; Sugimoto Y; Szpurka H; Clemente MJ; Ng KP; Muramatsu H; O'Keefe C; Saunthararajah Y; Maciejewski JP
    Leukemia; 2012 Jul; 26(7):1547-54. PubMed ID: 22246246
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.
    Liu CS; Yang-Yen HF; Suen CS; Hwang MJ; Yen JJ
    Sci Rep; 2017 Jul; 7(1):4613. PubMed ID: 28676638
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e).
    Li Y; Shen BF; Karanes C; Sensenbrenner L; Chen B
    J Immunol; 1995 Aug; 155(4):2165-74. PubMed ID: 7636265
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation.
    Wang Y; Cai D; Brendel C; Barett C; Erben P; Manley PW; Hochhaus A; Neubauer A; Burchert A
    Blood; 2007 Mar; 109(5):2147-55. PubMed ID: 17090651
    [TBL] [Abstract][Full Text] [Related]  

  • 11. G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.
    Zhu QS; Robinson LJ; Roginskaya V; Corey SJ
    Blood; 2004 May; 103(9):3305-12. PubMed ID: 14656892
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Roles of JAK kinases in human GM-CSF receptor signal transduction.
    Watanabe S; Itoh T; Arai K
    J Allergy Clin Immunol; 1996 Dec; 98(6 Pt 2):S183-91. PubMed ID: 8977526
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.
    Muramatsu H; Makishima H; Jankowska AM; Cazzolli H; O'Keefe C; Yoshida N; Xu Y; Nishio N; Hama A; Yagasaki H; Takahashi Y; Kato K; Manabe A; Kojima S; Maciejewski JP
    Blood; 2010 Mar; 115(10):1969-75. PubMed ID: 20008299
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.
    Chan RJ; Leedy MB; Munugalavadla V; Voorhorst CS; Li Y; Yu M; Kapur R
    Blood; 2005 May; 105(9):3737-42. PubMed ID: 15644411
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Roles of JAK kinase in human GM-CSF receptor signals.
    Watanabe S; Itoh T; Arai K
    Leukemia; 1997 Apr; 11 Suppl 3():76-8. PubMed ID: 9209304
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation.
    Wang L; Rudert WA; Loutaev I; Roginskaya V; Corey SJ
    Oncogene; 2002 Aug; 21(34):5346-55. PubMed ID: 12149655
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.
    Grishin A; Sinha S; Roginskaya V; Boyer MJ; Gomez-Cambronero J; Zuo S; Kurosaki T; Romero G; Corey SJ
    Oncogene; 2000 Jan; 19(1):97-105. PubMed ID: 10644984
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor.
    Soldi R; Primo L; Brizzi MF; Sanavio F; Aglietta M; Polentarutti N; Pegoraro L; Mantovani A; Bussolino F
    Blood; 1997 Feb; 89(3):863-72. PubMed ID: 9028317
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.
    Goodwin CB; Yang Z; Yin F; Yu M; Chan RJ
    Haematologica; 2012 Jul; 97(7):1042-7. PubMed ID: 22315502
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells.
    Okabe S; Tauchi T; Katagiri S; Tanaka Y; Ohyashiki K
    J Hematol Oncol; 2014 Apr; 7():37. PubMed ID: 24775308
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.