217 related articles for article (PubMed ID: 23697606)
1. The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs.
Yeap YY; Trevaskis NL; Porter CJ
Mol Pharm; 2013 Jul; 10(7):2601-15. PubMed ID: 23697606
[TBL] [Abstract][Full Text] [Related]
2. Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation.
Yeap YY; Trevaskis NL; Quach T; Tso P; Charman WN; Porter CJ
Mol Pharm; 2013 May; 10(5):1874-89. PubMed ID: 23480483
[TBL] [Abstract][Full Text] [Related]
3. Transient Supersaturation Supports Drug Absorption from Lipid-Based Formulations for Short Periods of Time, but Ongoing Solubilization Is Required for Longer Absorption Periods.
Crum MF; Trevaskis NL; Pouton CW; Porter CJ
Mol Pharm; 2017 Feb; 14(2):394-405. PubMed ID: 28002666
[TBL] [Abstract][Full Text] [Related]
4. Polymeric Precipitation Inhibitors Promote Fenofibrate Supersaturation and Enhance Drug Absorption from a Type IV Lipid-Based Formulation.
Suys EJA; Chalmers DK; Pouton CW; Porter CJH
Mol Pharm; 2018 Jun; 15(6):2355-2371. PubMed ID: 29659287
[TBL] [Abstract][Full Text] [Related]
5. Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations.
Sahbaz Y; Williams HD; Nguyen TH; Saunders J; Ford L; Charman SA; Scammells PJ; Porter CJ
Mol Pharm; 2015 Jun; 12(6):1980-91. PubMed ID: 25905624
[TBL] [Abstract][Full Text] [Related]
6. In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine.
Devraj R; Williams HD; Warren DB; Mohsin K; Porter CJ; Pouton CW
Eur J Pharm Sci; 2013 Jul; 49(4):748-60. PubMed ID: 23684915
[TBL] [Abstract][Full Text] [Related]
7. Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.
Williams HD; Anby MU; Sassene P; Kleberg K; Bakala-N'Goma JC; Calderone M; Jannin V; Igonin A; Partheil A; Marchaud D; Jule E; Vertommen J; Maio M; Blundell R; Benameur H; Carrière F; Müllertz A; Pouton CW; Porter CJ
Mol Pharm; 2012 Nov; 9(11):3286-300. PubMed ID: 23030411
[TBL] [Abstract][Full Text] [Related]
8. Lipid absorption triggers drug supersaturation at the intestinal unstirred water layer and promotes drug absorption from mixed micelles.
Yeap YY; Trevaskis NL; Porter CJ
Pharm Res; 2013 Dec; 30(12):3045-58. PubMed ID: 23793990
[TBL] [Abstract][Full Text] [Related]
9. Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs.
Kossena GA; Boyd BJ; Porter CJ; Charman WN
J Pharm Sci; 2003 Mar; 92(3):634-48. PubMed ID: 12587125
[TBL] [Abstract][Full Text] [Related]
10. Interaction with biliary and pancreatic fluids drives supersaturation and drug absorption from lipid-based formulations of low (saquinavir) and high (fenofibrate) permeability poorly soluble drugs.
Suys EJA; Brundel DHS; Chalmers DK; Pouton CW; Porter CJH
J Control Release; 2021 Mar; 331():45-61. PubMed ID: 33450318
[TBL] [Abstract][Full Text] [Related]
11. In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.
Devraj R; Williams HD; Warren DB; Mullertz A; Porter CJ; Pouton CW
Int J Pharm; 2013 Jan; 441(1-2):323-33. PubMed ID: 23178598
[TBL] [Abstract][Full Text] [Related]
12. Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems.
Anby MU; Williams HD; McIntosh M; Benameur H; Edwards GA; Pouton CW; Porter CJ
Mol Pharm; 2012 Jul; 9(7):2063-79. PubMed ID: 22656917
[TBL] [Abstract][Full Text] [Related]
13. Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of drug supersaturation that develops during in vitro digestion.
Devraj R; Williams HD; Warren DB; Porter CJ; Pouton CW
J Pharm Sci; 2014 Apr; 103(4):1050-63. PubMed ID: 24470073
[TBL] [Abstract][Full Text] [Related]
14. Drug solubilization behavior during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids.
Kaukonen AM; Boyd BJ; Charman WN; Porter CJ
Pharm Res; 2004 Feb; 21(2):254-60. PubMed ID: 15032306
[TBL] [Abstract][Full Text] [Related]
15. An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations.
Anby MU; Nguyen TH; Yeap YY; Feeney OM; Williams HD; Benameur H; Pouton CW; Porter CJ
Mol Pharm; 2014 Nov; 11(11):4069-83. PubMed ID: 25265395
[TBL] [Abstract][Full Text] [Related]
16. Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity.
Kleberg K; Jacobsen F; Fatouros DG; Müllertz A
J Pharm Sci; 2010 Aug; 99(8):3522-32. PubMed ID: 20564382
[TBL] [Abstract][Full Text] [Related]
17. Human intestinal fluid layer separation: The effect on colloidal structures & solubility of lipophilic compounds.
Riethorst D; Mitra A; Kesisoglou F; Xu W; Tack J; Brouwers J; Augustijns P
Eur J Pharm Biopharm; 2018 Aug; 129():104-110. PubMed ID: 29802985
[TBL] [Abstract][Full Text] [Related]
18. Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.
Larsen AT; Holm R; Müllertz A
Eur J Pharm Biopharm; 2017 Aug; 117():308-314. PubMed ID: 28465239
[TBL] [Abstract][Full Text] [Related]
19. Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro.
Keemink J; Mårtensson E; Bergström CAS
Mol Pharm; 2019 Mar; 16(3):921-930. PubMed ID: 30628771
[TBL] [Abstract][Full Text] [Related]
20. Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations.
Kaukonen AM; Boyd BJ; Porter CJ; Charman WN
Pharm Res; 2004 Feb; 21(2):245-53. PubMed ID: 15032305
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]