These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 23704982)

  • 1. Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor.
    Biela I; Tidten-Luksch N; Immekus F; Glinca S; Nguyen TX; Gerber HD; Heine A; Klebe G; Reuter K
    PLoS One; 2013; 8(5):e64240. PubMed ID: 23704982
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile.
    Romier C; Reuter K; Suck D; Ficner R
    Biochemistry; 1996 Dec; 35(49):15734-9. PubMed ID: 8961936
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase.
    Grädler U; Gerber HD; Goodenough-Lashua DM; Garcia GA; Ficner R; Reuter K; Stubbs MT; Klebe G
    J Mol Biol; 2001 Feb; 306(3):455-67. PubMed ID: 11178905
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding.
    Stengl B; Meyer EA; Heine A; Brenk R; Diederich F; Klebe G
    J Mol Biol; 2007 Jul; 370(3):492-511. PubMed ID: 17524419
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1.
    Johannsson S; Neumann P; Ficner R
    Biomolecules; 2018 Aug; 8(3):. PubMed ID: 30149595
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity.
    Grädler U; Ficner R; Garcia GA; Stubbs MT; Klebe G; Reuter K
    FEBS Lett; 1999 Jul; 454(1-2):142-6. PubMed ID: 10413112
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange.
    Romier C; Reuter K; Suck D; Ficner R
    EMBO J; 1996 Jun; 15(11):2850-7. PubMed ID: 8654383
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design.
    Brenk R; Stubbs MT; Heine A; Reuter K; Klebe G
    Chembiochem; 2003 Oct; 4(10):1066-77. PubMed ID: 14523925
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies.
    Tidten N; Stengl B; Heine A; Garcia GA; Klebe G; Reuter K
    J Mol Biol; 2007 Nov; 374(3):764-76. PubMed ID: 17949745
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism.
    Alqasem MA; Fergus C; Southern JM; Connon SJ; Kelly VP
    Chem Commun (Camb); 2020 Apr; 56(27):3915-3918. PubMed ID: 32149287
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural and functional insights into human tRNA guanine transgylcosylase.
    Sievers K; Welp L; Urlaub H; Ficner R
    RNA Biol; 2021 Oct; 18(sup1):382-396. PubMed ID: 34241577
    [TBL] [Abstract][Full Text] [Related]  

  • 12. An essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coli.
    Kittendorf JD; Sgraja T; Reuter K; Klebe G; Garcia GA
    J Biol Chem; 2003 Oct; 278(43):42369-76. PubMed ID: 12909636
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The role of aspartic acid 143 in E. coli tRNA-guanine transglycosylase: insights from mutagenesis studies and computational modeling.
    Todorov KA; Tan XJ; Nonekowski ST; Garcia GA; Carlson HA
    Biophys J; 2005 Sep; 89(3):1965-77. PubMed ID: 15951383
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate.
    Xie W; Liu X; Huang RH
    Nat Struct Biol; 2003 Oct; 10(10):781-8. PubMed ID: 12949492
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
    Sebastiani M; Behrens C; Dörr S; Gerber HD; Benazza R; Hernandez-Alba O; Cianférani S; Klebe G; Heine A; Reuter K
    ACS Chem Biol; 2022 Aug; 17(8):2229-2247. PubMed ID: 35815944
    [TBL] [Abstract][Full Text] [Related]  

  • 16. tRNA-guanine transglycosylase from Escherichia coli: recognition of full-length 'queuine-cognate' tRNAs.
    Kung FL; Garcia GA
    FEBS Lett; 1998 Jul; 431(3):427-32. PubMed ID: 9714557
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme.
    Reuter K; Ficner R
    J Bacteriol; 1995 Sep; 177(18):5284-8. PubMed ID: 7665516
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
    Ehrmann FR; Stojko J; Metz A; Debaene F; Barandun LJ; Heine A; Diederich F; Cianférani S; Reuter K; Klebe G
    PLoS One; 2017; 12(4):e0175723. PubMed ID: 28419165
    [TBL] [Abstract][Full Text] [Related]  

  • 19. High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
    Barandun LJ; Immekus F; Kohler PC; Ritschel T; Heine A; Orlando P; Klebe G; Diederich F
    Acta Crystallogr D Biol Crystallogr; 2013 Sep; 69(Pt 9):1798-807. PubMed ID: 23999303
    [TBL] [Abstract][Full Text] [Related]  

  • 20. From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters.
    Barandun LJ; Immekus F; Kohler PC; Tonazzi S; Wagner B; Wendelspiess S; Ritschel T; Heine A; Kansy M; Klebe G; Diederich F
    Chemistry; 2012 Jul; 18(30):9246-57. PubMed ID: 22736391
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.