These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
279 related articles for article (PubMed ID: 23705822)
1. Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation. Kaiyawet N; Rungrotmongkol T; Hannongbua S J Chem Inf Model; 2013 Jun; 53(6):1315-23. PubMed ID: 23705822 [TBL] [Abstract][Full Text] [Related]
2. The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR. Jarmuła A; Cieplak P; Krygowski TM; Rode W Bioorg Med Chem; 2007 Mar; 15(6):2346-58. PubMed ID: 17275316 [TBL] [Abstract][Full Text] [Related]
3. Relative free energies of binding to thymidylate synthase of 2- and/or 4-thio and/or 5-fluoro analogues of dUMP. Jarmuła A; Cieplak P; Leś A; Rode W J Comput Aided Mol Des; 2003 Oct; 17(10):699-710. PubMed ID: 15068368 [TBL] [Abstract][Full Text] [Related]
4. Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate. Matthews DA; Villafranca JE; Janson CA; Smith WW; Welsh K; Freer S J Mol Biol; 1990 Aug; 214(4):937-48. PubMed ID: 2201779 [TBL] [Abstract][Full Text] [Related]
6. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Almog R; Waddling CA; Maley F; Maley GF; Van Roey P Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879 [TBL] [Abstract][Full Text] [Related]
7. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Newby Z; Lee TT; Morse RJ; Liu Y; Liu L; Venkatraman P; Santi DV; Finer-Moore JS; Stroud RM Biochemistry; 2006 Jun; 45(24):7415-28. PubMed ID: 16768437 [TBL] [Abstract][Full Text] [Related]
8. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Finer-Moore JS; Liu L; Schafmeister CE; Birdsall DL; Mau T; Santi DV; Stroud RM Biochemistry; 1996 Apr; 35(16):5125-36. PubMed ID: 8611496 [TBL] [Abstract][Full Text] [Related]
10. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis. Spencer HT; Villafranca JE; Appleman JR Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016 [TBL] [Abstract][Full Text] [Related]
11. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254. Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646 [TBL] [Abstract][Full Text] [Related]
12. Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation. Carreras CW; Climie SC; Santi DV Biochemistry; 1992 Jul; 31(26):6038-44. PubMed ID: 1627546 [TBL] [Abstract][Full Text] [Related]
13. Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase. Hughey CT; Barbour KW; Berger FG; Berger SH Mol Pharmacol; 1993 Aug; 44(2):316-23. PubMed ID: 8355668 [TBL] [Abstract][Full Text] [Related]
14. A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction. Garvey EP; Santi DV J Biol Chem; 1987 Jul; 262(19):9068-74. PubMed ID: 3597407 [TBL] [Abstract][Full Text] [Related]
15. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Hyatt DC; Maley F; Montfort WR Biochemistry; 1997 Apr; 36(15):4585-94. PubMed ID: 9109668 [TBL] [Abstract][Full Text] [Related]
16. Modification of Escherichia coli thymidylate synthase at tyrosine-94 by 5-imidazolylpropynyl-2'-deoxyuridine 5'-monophosphate. Saxl RL; Reston J; Nie Z; Kalman TI; Maley F Biochemistry; 2003 Apr; 42(15):4544-51. PubMed ID: 12693951 [TBL] [Abstract][Full Text] [Related]
17. Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Perry KM; Carreras CW; Chang LC; Santi DV; Stroud RM Biochemistry; 1993 Jul; 32(28):7116-25. PubMed ID: 8343503 [TBL] [Abstract][Full Text] [Related]
18. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil. Spears CP; Gustavsson BG; Berne M; Frösing R; Bernstein L; Hayes AA Cancer Res; 1988 Oct; 48(20):5894-900. PubMed ID: 3167844 [TBL] [Abstract][Full Text] [Related]
19. Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase. Reilly RT; Barbour KW; Dunlap RB; Berger FG Mol Pharmacol; 1995 Jul; 48(1):72-9. PubMed ID: 7623777 [TBL] [Abstract][Full Text] [Related]
20. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. Stout TJ; Stroud RM Structure; 1996 Jan; 4(1):67-77. PubMed ID: 8805515 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]