338 related articles for article (PubMed ID: 23774792)
1. Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.
Murphy SR; Chang CC; Dogbevia G; Bryleva EY; Bowen Z; Hasan MT; Chang TY
Mol Ther; 2013 Aug; 21(8):1497-506. PubMed ID: 23774792
[TBL] [Abstract][Full Text] [Related]
2. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
Shibuya Y; Niu Z; Bryleva EY; Harris BT; Murphy SR; Kheirollah A; Bowen ZD; Chang CCY; Chang TY
Neurobiol Aging; 2015 Jul; 36(7):2248-2259. PubMed ID: 25930235
[TBL] [Abstract][Full Text] [Related]
3. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Bryleva EY; Rogers MA; Chang CC; Buen F; Harris BT; Rousselet E; Seidah NG; Oddo S; LaFerla FM; Spencer TA; Hickey WF; Chang TY
Proc Natl Acad Sci U S A; 2010 Feb; 107(7):3081-6. PubMed ID: 20133765
[TBL] [Abstract][Full Text] [Related]
4. ACAT1 as a Therapeutic Target and its Genetic Relationship with Alzheimer's Disease.
Alavez-Rubio JS; Juarez-Cedillo T
Curr Alzheimer Res; 2019; 16(8):699-709. PubMed ID: 31441726
[TBL] [Abstract][Full Text] [Related]
5. Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
Chen Y; Zhu L; Ji L; Yang Y; Lu L; Wang X; Zhou G
Med Sci Monit; 2018 Dec; 24():9007-9018. PubMed ID: 30541014
[TBL] [Abstract][Full Text] [Related]
6. ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease.
Shibuya Y; Chang CC; Chang TY
Future Med Chem; 2015; 7(18):2451-67. PubMed ID: 26669800
[TBL] [Abstract][Full Text] [Related]
7. Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
Griciuc A; Federico AN; Natasan J; Forte AM; McGinty D; Nguyen H; Volak A; LeRoy S; Gandhi S; Lerner EP; Hudry E; Tanzi RE; Maguire CA
Hum Mol Genet; 2020 Oct; 29(17):2920-2935. PubMed ID: 32803224
[TBL] [Abstract][Full Text] [Related]
8. Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS1 transgenic mice.
Wang QH; Wang YR; Zhang T; Jiao SS; Liu YH; Zeng F; Li J; Yao XQ; Zhou HD; Zhou XF; Wang YJ
J Neurochem; 2016 Jul; 138(1):163-73. PubMed ID: 26991827
[TBL] [Abstract][Full Text] [Related]
9. Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Huang LH; Melton EM; Li H; Sohn P; Rogers MA; Mulligan-Kehoe MJ; Fiering SN; Hickey WF; Chang CC; Chang TY
J Biol Chem; 2016 Mar; 291(12):6232-44. PubMed ID: 26801614
[TBL] [Abstract][Full Text] [Related]
10. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
Zhao L; Gottesdiener AJ; Parmar M; Li M; Kaminsky SM; Chiuchiolo MJ; Sondhi D; Sullivan PM; Holtzman DM; Crystal RG; Paul SM
Neurobiol Aging; 2016 Aug; 44():159-172. PubMed ID: 27318144
[TBL] [Abstract][Full Text] [Related]
11. Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow.
Wakabayashi T; Takahashi M; Yamamuro D; Karasawa T; Takei A; Takei S; Yamazaki H; Nagashima S; Ebihara K; Takahashi M; Ishibashi S
Arterioscler Thromb Vasc Biol; 2018 Nov; 38(11):2576-2589. PubMed ID: 30354239
[TBL] [Abstract][Full Text] [Related]
12. Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice.
De La Torre AL; Huynh TN; Chang CCY; Pooler DB; Ness DB; Lewis LD; Pannem S; Feng Y; Samkoe KS; Hickey WF; Chang TY
Int J Mol Sci; 2023 Jul; 24(13):. PubMed ID: 37446191
[TBL] [Abstract][Full Text] [Related]
13. Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology.
Yang Y; Seok MJ; Kim YE; Choi Y; Song JJ; Sulistio YA; Kim SH; Chang MY; Oh SJ; Nam MH; Kim YK; Kim TG; Im HI; Koh SH; Lee SH
Mol Psychiatry; 2023 Dec; 28(12):5359-5374. PubMed ID: 35902630
[TBL] [Abstract][Full Text] [Related]
14. ACAT inhibition and amyloid beta reduction.
Bhattacharyya R; Kovacs DM
Biochim Biophys Acta; 2010 Aug; 1801(8):960-5. PubMed ID: 20398792
[TBL] [Abstract][Full Text] [Related]
15. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.
Janelsins MC; Mastrangelo MA; Park KM; Sudol KL; Narrow WC; Oddo S; LaFerla FM; Callahan LM; Federoff HJ; Bowers WJ
Am J Pathol; 2008 Dec; 173(6):1768-82. PubMed ID: 18974297
[TBL] [Abstract][Full Text] [Related]
16. Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
Shibuya Y; Chang CC; Huang LH; Bryleva EY; Chang TY
J Neurosci; 2014 Oct; 34(43):14484-501. PubMed ID: 25339759
[TBL] [Abstract][Full Text] [Related]
17. Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease.
Fukuchi K; Tahara K; Kim HD; Maxwell JA; Lewis TL; Accavitti-Loper MA; Kim H; Ponnazhagan S; Lalonde R
Neurobiol Dis; 2006 Sep; 23(3):502-11. PubMed ID: 16766200
[TBL] [Abstract][Full Text] [Related]
18. MiR-340 Reduces the Accumulation of Amyloid-β Through Targeting BACE1 (β-site Amyloid Precursor Protein Cleaving Enzyme 1) in Alzheimer's Disease.
Tan X; Luo Y; Pi D; Xia L; Li Z; Tu Q
Curr Neurovasc Res; 2020; 17(1):86-92. PubMed ID: 31957613
[TBL] [Abstract][Full Text] [Related]
19. Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice.
Zeng CY; Yang TT; Zhou HJ; Zhao Y; Kuang X; Duan W; Du JR
Neurobiol Aging; 2019 Jun; 78():18-28. PubMed ID: 30851437
[TBL] [Abstract][Full Text] [Related]
20. MicroRNA-29c targets β-site amyloid precursor protein-cleaving enzyme 1 and has a neuroprotective role in vitro and in vivo.
Yang G; Song Y; Zhou X; Deng Y; Liu T; Weng G; Yu D; Pan S
Mol Med Rep; 2015 Aug; 12(2):3081-8. PubMed ID: 25955795
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]