208 related articles for article (PubMed ID: 23779221)
1. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.
Huang D; Xia M; Li S; Wen J; Jia X
J Ind Microbiol Biotechnol; 2013 Sep; 40(9):1023-37. PubMed ID: 23779221
[TBL] [Abstract][Full Text] [Related]
2. Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil.
Wang J; Liu H; Huang D; Jin L; Wang C; Wen J
Appl Microbiol Biotechnol; 2017 Mar; 101(6):2447-2465. PubMed ID: 28175948
[TBL] [Abstract][Full Text] [Related]
3. Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement.
Huang D; Li S; Xia M; Wen J; Jia X
Microb Cell Fact; 2013 May; 12():52. PubMed ID: 23705993
[TBL] [Abstract][Full Text] [Related]
4. Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis.
Wu QB; Zhang XY; Chen XA; Li YQ
Microb Cell Fact; 2021 Aug; 20(1):166. PubMed ID: 34425854
[TBL] [Abstract][Full Text] [Related]
5. Combination of atmospheric and room temperature plasma (ARTP) mutagenesis, genome shuffling and dimethyl sulfoxide (DMSO) feeding to improve FK506 production in Streptomyces tsukubaensis.
Ye L; Ye R; Hu F; Wang G
Biotechnol Lett; 2021 Sep; 43(9):1809-1820. PubMed ID: 34160747
[TBL] [Abstract][Full Text] [Related]
6. Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.
Chen D; Zhang Q; Zhang Q; Cen P; Xu Z; Liu W
Appl Environ Microbiol; 2012 Aug; 78(15):5093-103. PubMed ID: 22582065
[TBL] [Abstract][Full Text] [Related]
7. Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011.
Mo S; Lee SK; Jin YY; Oh CH; Suh JW
Appl Microbiol Biotechnol; 2013 Apr; 97(7):3053-62. PubMed ID: 23053074
[TBL] [Abstract][Full Text] [Related]
8. Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.
Blažič M; Kosec G; Baebler Š; Gruden K; Petković H
Microb Cell Fact; 2015 Oct; 14():164. PubMed ID: 26466669
[TBL] [Abstract][Full Text] [Related]
9. Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
Motamedi H; Shafiee A; Cai SJ; Streicher SL; Arison BH; Miller RR
J Bacteriol; 1996 Sep; 178(17):5243-8. PubMed ID: 8752344
[TBL] [Abstract][Full Text] [Related]
10. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
Andexer JN; Kendrew SG; Nur-e-Alam M; Lazos O; Foster TA; Zimmermann AS; Warneck TD; Suthar D; Coates NJ; Koehn FE; Skotnicki JS; Carter GT; Gregory MA; Martin CJ; Moss SJ; Leadlay PF; Wilkinson B
Proc Natl Acad Sci U S A; 2011 Mar; 108(12):4776-81. PubMed ID: 21383123
[TBL] [Abstract][Full Text] [Related]
11. Production improvement of FK506 in Streptomyces tsukubaensis by metabolic engineering strategy.
Chen HT; Zhang XY; Wu QB; Zhao QW; Chen XA; Li YQ
J Appl Microbiol; 2023 Jul; 134(7):. PubMed ID: 37429605
[TBL] [Abstract][Full Text] [Related]
12. Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).
Barreiro C; Prieto C; Sola-Landa A; Solera E; Martínez-Castro M; Pérez-Redondo R; García-Estrada C; Aparicio JF; Fernández-Martínez LT; Santos-Aberturas J; Salehi-Najafabadi Z; Rodríguez-García A; Tauch A; Martín JF
J Bacteriol; 2012 Jul; 194(14):3756-7. PubMed ID: 22740677
[TBL] [Abstract][Full Text] [Related]
13. Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach.
Mo S; Lee SK; Jin YY; Suh JW
J Microbiol Biotechnol; 2016 Feb; 26(2):233-40. PubMed ID: 26502733
[TBL] [Abstract][Full Text] [Related]
14. FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.
Zhang XS; Luo HD; Tao Y; Wang YY; Jiang XH; Jiang H; Li YQ
J Ind Microbiol Biotechnol; 2016 Dec; 43(12):1693-1703. PubMed ID: 27757551
[TBL] [Abstract][Full Text] [Related]
15. Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.
Mo S; Yoo YJ; Ban YH; Lee SK; Kim E; Suh JW; Yoon YJ
Appl Environ Microbiol; 2012 Apr; 78(7):2249-55. PubMed ID: 22267670
[TBL] [Abstract][Full Text] [Related]
16. Novel chemobiosynthetic approach for exclusive production of FK506.
Kosec G; Goranovič D; Mrak P; Fujs S; Kuščer E; Horvat J; Kopitar G; Petković H
Metab Eng; 2012 Jan; 14(1):39-46. PubMed ID: 22100790
[TBL] [Abstract][Full Text] [Related]
17. Origin of the allyl group in FK506 biosynthesis.
Goranovic D; Kosec G; Mrak P; Fujs S; Horvat J; Kuscer E; Kopitar G; Petkovic H
J Biol Chem; 2010 May; 285(19):14292-300. PubMed ID: 20194504
[TBL] [Abstract][Full Text] [Related]
18. Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.
Ordóñez-Robles M; Rodríguez-García A; Martín JF
Appl Microbiol Biotechnol; 2016 Sep; 100(18):8091-103. PubMed ID: 27357227
[TBL] [Abstract][Full Text] [Related]
19. Optimization of the precursor supply for an enhanced FK506 production in
Schulz S; Schall C; Stehle T; Breitmeyer C; Krysenko S; Mitulski A; Wohlleben W
Front Bioeng Biotechnol; 2022; 10():1067467. PubMed ID: 36466343
[TBL] [Abstract][Full Text] [Related]
20. Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.
Xia M; Huang D; Li S; Wen J; Jia X; Chen Y
Biotechnol Bioeng; 2013 Oct; 110(10):2717-30. PubMed ID: 23682004
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
