BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

528 related articles for article (PubMed ID: 23791707)

  • 1. γ-Secretase inhibitors and modulators.
    Golde TE; Koo EH; Felsenstein KM; Osborne BA; Miele L
    Biochim Biophys Acta; 2013 Dec; 1828(12):2898-907. PubMed ID: 23791707
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development and mechanism of γ-secretase modulators for Alzheimer's disease.
    Crump CJ; Johnson DS; Li YM
    Biochemistry; 2013 May; 52(19):3197-216. PubMed ID: 23614767
    [TBL] [Abstract][Full Text] [Related]  

  • 3. γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
    Lessard CB; Rodriguez E; Ladd TB; Minter LM; Osborne BA; Miele L; Golde TE; Ran Y
    Alzheimers Res Ther; 2020 May; 12(1):61. PubMed ID: 32430033
    [TBL] [Abstract][Full Text] [Related]  

  • 4. γ-Secretase in Alzheimer's disease.
    Hur JY
    Exp Mol Med; 2022 Apr; 54(4):433-446. PubMed ID: 35396575
    [TBL] [Abstract][Full Text] [Related]  

  • 5. gamma-Secretase as a therapeutic target in Alzheimer's disease.
    Guardia-Laguarta C; Pera M; Lleó A
    Curr Drug Targets; 2010 Apr; 11(4):506-17. PubMed ID: 20015011
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substrate-targeting gamma-secretase modulators.
    Kukar TL; Ladd TB; Bann MA; Fraering PC; Narlawar R; Maharvi GM; Healy B; Chapman R; Welzel AT; Price RW; Moore B; Rangachari V; Cusack B; Eriksen J; Jansen-West K; Verbeeck C; Yager D; Eckman C; Ye W; Sagi S; Cottrell BA; Torpey J; Rosenberry TL; Fauq A; Wolfe MS; Schmidt B; Walsh DM; Koo EH; Golde TE
    Nature; 2008 Jun; 453(7197):925-9. PubMed ID: 18548070
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
    Weissmiller AM; Natera-Naranjo O; Reyna SM; Pearn ML; Zhao X; Nguyen P; Cheng S; Goldstein LS; Tanzi RE; Wagner SL; Mobley WC; Wu C
    PLoS One; 2015; 10(2):e0118379. PubMed ID: 25710492
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A fast growing spectrum of biological functions of γ-secretase in development and disease.
    Jurisch-Yaksi N; Sannerud R; Annaert W
    Biochim Biophys Acta; 2013 Dec; 1828(12):2815-27. PubMed ID: 24099003
    [TBL] [Abstract][Full Text] [Related]  

  • 10. γ-Secretase and its modulators: Twenty years and beyond.
    Xia W
    Neurosci Lett; 2019 May; 701():162-169. PubMed ID: 30763650
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
    Hahn S; Brüning T; Ness J; Czirr E; Baches S; Gijsen H; Korth C; Pietrzik CU; Bulic B; Weggen S
    J Neurochem; 2011 Feb; 116(3):385-95. PubMed ID: 21091478
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
    Ben Halima S; Mishra S; Raja KMP; Willem M; Baici A; Simons K; Brüstle O; Koch P; Haass C; Caflisch A; Rajendran L
    Cell Rep; 2016 Mar; 14(9):2127-2141. PubMed ID: 26923602
    [TBL] [Abstract][Full Text] [Related]  

  • 13. γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
    Weber TA; Lundkvist J; Wanngren J; Kvartsberg H; Jin S; Larssen P; Wu D; Oliveira DV; Minta K; Brinkmalm G; Zetterberg H; Blennow K; Nordvall G; Winblad B; Portelius E; Karlström H
    J Cell Mol Med; 2022 Feb; 26(3):880-892. PubMed ID: 34931449
    [TBL] [Abstract][Full Text] [Related]  

  • 14. γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase.
    Gertsik N; Chau DM; Li YM
    ACS Chem Biol; 2015 Aug; 10(8):1925-31. PubMed ID: 26030233
    [TBL] [Abstract][Full Text] [Related]  

  • 15. γ-Secretase inhibitors and modulators for Alzheimer's disease.
    Wolfe MS
    J Neurochem; 2012 Jan; 120 Suppl 1(Suppl 1):89-98. PubMed ID: 22122056
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein.
    Beel AJ; Barrett P; Schnier PD; Hitchcock SA; Bagal D; Sanders CR; Jordan JB
    Biochemistry; 2009 Dec; 48(50):11837-9. PubMed ID: 19928774
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.
    De Strooper B; Chávez Gutiérrez L
    Annu Rev Pharmacol Toxicol; 2015; 55():419-37. PubMed ID: 25292430
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of γ-Secretase Inhibitors for the Treatment of Diverse Disease Conditions through Inhibition of Notch Signaling Pathway.
    Mondal A; Bose S; Banerjee S; Pal D
    Curr Drug Targets; 2021; 22(15):1799-1807. PubMed ID: 33992061
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
    Feilen LP; Chen SY; Fukumori A; Feederle R; Zacharias M; Steiner H
    Elife; 2022 May; 11():. PubMed ID: 35579427
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Advances in gamma-secretase modulation.
    Pissarnitski D
    Curr Opin Drug Discov Devel; 2007 Jul; 10(4):392-402. PubMed ID: 17659480
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.