113 related articles for article (PubMed ID: 23796689)
1. A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development.
Maillard MC; Dominguez C; Gemkow MJ; Krieger F; Park H; Schaertl S; Winkler D; Muñoz-Sanjuán I
J Biomol Screen; 2013 Sep; 18(8):868-78. PubMed ID: 23796689
[TBL] [Abstract][Full Text] [Related]
2. Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7.
Limpachayaporn P; Riemann B; Kopka K; Schober O; Schäfers M; Haufe G
Eur J Med Chem; 2013 Jun; 64():562-78. PubMed ID: 23685941
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.
Limpachayaporn P; Schäfers M; Schober O; Kopka K; Haufe G
Bioorg Med Chem; 2013 Apr; 21(7):2025-36. PubMed ID: 23411396
[TBL] [Abstract][Full Text] [Related]
4. Assay development and screening of human DGAT1 inhibitors with an LC/MS-based assay: application of mass spectrometry for large-scale primary screening.
Zhang JH; Roddy TP; Ho PI; Horvath CR; Vickers C; Stout S; Hubbard B; Wang YK; Hill WA; Bojanic D
J Biomol Screen; 2010 Jul; 15(6):695-702. PubMed ID: 20484097
[TBL] [Abstract][Full Text] [Related]
5. Coupling liquid chromatography/mass spectrometry detection with microfluidic droplet array for label-free enzyme inhibition assay.
Wang XL; Zhu Y; Fang Q
Analyst; 2014 Jan; 139(1):191-7. PubMed ID: 24196165
[TBL] [Abstract][Full Text] [Related]
6. A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions.
Zhu Q; Gao L; Chen Z; Zheng S; Shu H; Li J; Jiang H; Liu S
Eur J Med Chem; 2012 Aug; 54():232-8. PubMed ID: 22652225
[TBL] [Abstract][Full Text] [Related]
7. Assays of endogenous caspase activities: a comparison of mass spectrometry and fluorescence formats.
Su J; Rajapaksha TW; Peter ME; Mrksich M
Anal Chem; 2006 Jul; 78(14):4945-51. PubMed ID: 16841915
[TBL] [Abstract][Full Text] [Related]
8. Mass spectrometric techniques for label-free high-throughput screening in drug discovery.
Roddy TP; Horvath CR; Stout SJ; Kenney KL; Ho PI; Zhang JH; Vickers C; Kaushik V; Hubbard B; Wang YK
Anal Chem; 2007 Nov; 79(21):8207-13. PubMed ID: 17902631
[TBL] [Abstract][Full Text] [Related]
9. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2.
Castro MM; Fuah J; Ali M; Sung M; Schulz J; Kondo MY; Fan X; Holt A; Schulz R
Biochem Pharmacol; 2013 Aug; 86(4):469-75. PubMed ID: 23774623
[TBL] [Abstract][Full Text] [Related]
10. Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).
Winkler D; Beconi M; Toledo-Sherman LM; Prime M; Ebneth A; Dominguez C; Muñoz-Sanjuan I
J Biomol Screen; 2013 Sep; 18(8):879-89. PubMed ID: 23690293
[TBL] [Abstract][Full Text] [Related]
11. 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.
Kopka K; Faust A; Keul P; Wagner S; Breyholz HJ; Höltke C; Schober O; Schäfers M; Levkau B
J Med Chem; 2006 Nov; 49(23):6704-15. PubMed ID: 17154501
[TBL] [Abstract][Full Text] [Related]
12. Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based high-throughput screening of time-dependent CYP inhibitors.
Dasgupta M; Tang W; Caldwell GW; Yan Z
Rapid Commun Mass Spectrom; 2010 Aug; 24(15):2177-85. PubMed ID: 20583325
[TBL] [Abstract][Full Text] [Related]
13. Evaluation of laser diode thermal desorption (LDTD) coupled with tandem mass spectrometry (MS/MS) for support of in vitro drug discovery assays: increasing scope, robustness and throughput of the LDTD technique for use with chemically diverse compound libraries.
Beattie I; Smith A; Weston DJ; White P; Szwandt S; Sealey L
J Pharm Biomed Anal; 2012 Feb; 59():18-28. PubMed ID: 22071442
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.
Liu D; Tian Z; Yan Z; Wu L; Ma Y; Wang Q; Liu W; Zhou H; Yang C
Bioorg Med Chem; 2013 Jun; 21(11):2960-7. PubMed ID: 23632366
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.
Limpachayaporn P; Wagner S; Kopka K; Schober O; Schäfers M; Haufe G
J Med Chem; 2014 Nov; 57(22):9383-95. PubMed ID: 25358116
[TBL] [Abstract][Full Text] [Related]
16. Identification of DGAT2 Inhibitors Using Mass Spectrometry.
Song XS; Zhang J; Chen X; Palyha O; Chung C; Sonatore LM; Wilsie L; Stout S; McLaren DG; Taggart A; Imbriglio JE; Pinto S; Garcia-Calvo M; Addona GH
J Biomol Screen; 2016 Feb; 21(2):117-26. PubMed ID: 26403520
[TBL] [Abstract][Full Text] [Related]
17. Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.
Podichetty AK; Faust A; Kopka K; Wagner S; Schober O; Schäfers M; Haufe G
Bioorg Med Chem; 2009 Apr; 17(7):2680-8. PubMed ID: 19299147
[TBL] [Abstract][Full Text] [Related]
18. Development of a quantitative LC-MS/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay.
Smalley J; Marino AM; Xin B; Olah T; Balimane PV
J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Jul; 854(1-2):260-7. PubMed ID: 17524973
[TBL] [Abstract][Full Text] [Related]
19. Selective detection and inhibition of active caspase-3 in cells with optimized peptides.
Vickers CJ; González-Páez GE; Wolan DW
J Am Chem Soc; 2013 Aug; 135(34):12869-76. PubMed ID: 23915420
[TBL] [Abstract][Full Text] [Related]
20. Development of an ultrafiltration-liquid chromatography/mass spectrometry (UF-LC/MS) based ligand-binding assay and an LC/MS based functional assay for Mycobacterium tuberculosis shikimate kinase.
Mulabagal V; Calderón AI
Anal Chem; 2010 May; 82(9):3616-21. PubMed ID: 20394394
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]