BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 23798390)

  • 1. Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.
    Sigala PA; Fafarman AT; Schwans JP; Fried SD; Fenn TD; Caaveiro JM; Pybus B; Ringe D; Petsko GA; Boxer SG; Herschlag D
    Proc Natl Acad Sci U S A; 2013 Jul; 110(28):E2552-61. PubMed ID: 23798390
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hydrogen bonding in the active site of ketosteroid isomerase: electronic inductive effects and hydrogen bond coupling.
    Hanoian P; Sigala PA; Herschlag D; Hammes-Schiffer S
    Biochemistry; 2010 Dec; 49(48):10339-48. PubMed ID: 21049962
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.
    Schwans JP; Sunden F; Gonzalez A; Tsai Y; Herschlag D
    Biochemistry; 2013 Nov; 52(44):7840-55. PubMed ID: 24151972
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Proton affinity of the oxyanion hole in the active site of ketosteroid isomerase.
    Childs W; Boxer SG
    Biochemistry; 2010 Mar; 49(12):2725-31. PubMed ID: 20143849
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.
    Natarajan A; Schwans JP; Herschlag D
    J Am Chem Soc; 2014 May; 136(21):7643-54. PubMed ID: 24787954
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.
    Fafarman AT; Sigala PA; Schwans JP; Fenn TD; Herschlag D; Boxer SG
    Proc Natl Acad Sci U S A; 2012 Feb; 109(6):E299-308. PubMed ID: 22308339
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole.
    Kraut DA; Sigala PA; Fenn TD; Herschlag D
    Proc Natl Acad Sci U S A; 2010 Feb; 107(5):1960-5. PubMed ID: 20080683
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Critical Test of the Electrostatic Contribution to Catalysis with Noncanonical Amino Acids in Ketosteroid Isomerase.
    Wu Y; Boxer SG
    J Am Chem Soc; 2016 Sep; 138(36):11890-5. PubMed ID: 27545569
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hybrid quantum/classical molecular dynamics simulations of the proton transfer reactions catalyzed by ketosteroid isomerase: analysis of hydrogen bonding, conformational motions, and electrostatics.
    Chakravorty DK; Soudackov AV; Hammes-Schiffer S
    Biochemistry; 2009 Nov; 48(44):10608-19. PubMed ID: 19799395
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hydrogen bond coupling in the ketosteroid isomerase active site.
    Sigala PA; Caaveiro JM; Ringe D; Petsko GA; Herschlag D
    Biochemistry; 2009 Jul; 48(29):6932-9. PubMed ID: 19469568
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Water in the active site of ketosteroid isomerase.
    Hanoian P; Hammes-Schiffer S
    Biochemistry; 2011 Aug; 50(31):6689-700. PubMed ID: 21710970
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Contribution of the hydrogen-bond network involving a tyrosine triad in the active site to the structure and function of a highly proficient ketosteroid isomerase from Pseudomonas putida biotype B.
    Kim DH; Jang DS; Nam GH; Choi G; Kim JS; Ha NC; Kim MS; Oh BH; Choi KY
    Biochemistry; 2000 Apr; 39(16):4581-9. PubMed ID: 10769113
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pseudoreversion of the catalytic activity of Y14F by the additional substitution(s) of tyrosine with phenylalanine in the hydrogen bond network of delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B.
    Choi G; Ha NC; Kim MS; Hong BH; Oh BH; Choi KY
    Biochemistry; 2001 Jun; 40(23):6828-35. PubMed ID: 11389596
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proton Network Flexibility Enables Robustness and Large Electric Fields in the Ketosteroid Isomerase Active Site.
    Wang L; Fried SD; Markland TE
    J Phys Chem B; 2017 Oct; 121(42):9807-9815. PubMed ID: 28915043
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Contribution of a low-barrier hydrogen bond to catalysis is not significant in ketosteroid isomerase.
    Jang DS; Choi G; Cha HJ; Shin S; Hong BH; Lee HJ; Lee HC; Choi KY
    Mol Cells; 2015 May; 38(5):409-15. PubMed ID: 25947291
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site.
    Wang L; Fried SD; Boxer SG; Markland TE
    Proc Natl Acad Sci U S A; 2014 Dec; 111(52):18454-9. PubMed ID: 25503367
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole.
    Sigala PA; Kraut DA; Caaveiro JM; Pybus B; Ruben EA; Ringe D; Petsko GA; Herschlag D
    J Am Chem Soc; 2008 Oct; 130(41):13696-708. PubMed ID: 18808119
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole.
    Kraut DA; Sigala PA; Pybus B; Liu CW; Ringe D; Petsko GA; Herschlag D
    PLoS Biol; 2006 Apr; 4(4):e99. PubMed ID: 16602823
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Asp-99 donates a hydrogen bond not to Tyr-14 but to the steroid directly in the catalytic mechanism of Delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B.
    Choi G; Ha NC; Kim SW; Kim DH; Park S; Oh BH; Choi KY
    Biochemistry; 2000 Feb; 39(5):903-9. PubMed ID: 10653633
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural double-mutant cycle analysis of a hydrogen bond network in ketosteroid isomerase from Pseudomonas putida biotype B.
    Jang DS; Cha HJ; Cha SS; Hong BH; Ha NC; Lee JY; Oh BH; Lee HS; Choi KY
    Biochem J; 2004 Sep; 382(Pt 3):967-73. PubMed ID: 15228388
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.