These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

260 related articles for article (PubMed ID: 23798413)

  • 1. Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site.
    Schwans JP; Sunden F; Lassila JK; Gonzalez A; Tsai Y; Herschlag D
    Proc Natl Acad Sci U S A; 2013 Jul; 110(28):11308-13. PubMed ID: 23798413
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ground state destabilization from a positioned general base in the ketosteroid isomerase active site.
    Ruben EA; Schwans JP; Sonnett M; Natarajan A; Gonzalez A; Tsai Y; Herschlag D
    Biochemistry; 2013 Feb; 52(6):1074-81. PubMed ID: 23311398
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.
    Schwans JP; Hanoian P; Lengerich BJ; Sunden F; Gonzalez A; Tsai Y; Hammes-Schiffer S; Herschlag D
    Biochemistry; 2014 Apr; 53(15):2541-55. PubMed ID: 24597914
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evaluation of the Catalytic Contribution from a Positioned General Base in Ketosteroid Isomerase.
    Lamba V; Yabukarski F; Pinney M; Herschlag D
    J Am Chem Soc; 2016 Aug; 138(31):9902-9. PubMed ID: 27410422
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.
    Schwans JP; Sunden F; Gonzalez A; Tsai Y; Herschlag D
    Biochemistry; 2013 Nov; 52(44):7840-55. PubMed ID: 24151972
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole.
    Kraut DA; Sigala PA; Fenn TD; Herschlag D
    Proc Natl Acad Sci U S A; 2010 Feb; 107(5):1960-5. PubMed ID: 20080683
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.
    Natarajan A; Schwans JP; Herschlag D
    J Am Chem Soc; 2014 May; 136(21):7643-54. PubMed ID: 24787954
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.
    Schwans JP; Kraut DA; Herschlag D
    Proc Natl Acad Sci U S A; 2009 Aug; 106(34):14271-5. PubMed ID: 19706511
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The conserved cis-Pro39 residue plays a crucial role in the proper positioning of the catalytic base Asp38 in ketosteroid isomerase from Comamonas testosteroni.
    Nam GH; Cha SS; Yun YS; Oh YH; Hong BH; Lee HS; Choi KY
    Biochem J; 2003 Oct; 375(Pt 2):297-305. PubMed ID: 12852789
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Roles of active site aromatic residues in catalysis by ketosteroid isomerase from Pseudomonas putida biotype B.
    Kim DH; Nam GH; Jang DS; Choi G; Joo S; Kim JS; Oh BH; Choi KY
    Biochemistry; 1999 Oct; 38(42):13810-9. PubMed ID: 10529226
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hydrogen bonding in the active site of ketosteroid isomerase: electronic inductive effects and hydrogen bond coupling.
    Hanoian P; Sigala PA; Herschlag D; Hammes-Schiffer S
    Biochemistry; 2010 Dec; 49(48):10339-48. PubMed ID: 21049962
    [TBL] [Abstract][Full Text] [Related]  

  • 12. QM/MM modelling of ketosteroid isomerase reactivity indicates that active site closure is integral to catalysis.
    van der Kamp MW; Chaudret R; Mulholland AJ
    FEBS J; 2013 Jul; 280(13):3120-31. PubMed ID: 23356661
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of conserved Met112 residue in the catalytic activity and stability of ketosteroid isomerase.
    Cha HJ; Jang do S; Jeong JH; Hong BH; Yun YS; Shin EJ; Choi KY
    Biochim Biophys Acta; 2016 Oct; 1864(10):1322-7. PubMed ID: 27375051
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A Critical Test of the Electrostatic Contribution to Catalysis with Noncanonical Amino Acids in Ketosteroid Isomerase.
    Wu Y; Boxer SG
    J Am Chem Soc; 2016 Sep; 138(36):11890-5. PubMed ID: 27545569
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure and enzymology of Delta5-3-ketosteroid isomerase.
    Ha NC; Choi G; Choi KY; Oh BH
    Curr Opin Struct Biol; 2001 Dec; 11(6):674-8. PubMed ID: 11751047
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A tale of two isomerases: compact versus extended active sites in ketosteroid isomerase and phosphoglucose isomerase.
    Somarowthu S; Brodkin HR; D'Aquino JA; Ringe D; Ondrechen MJ; Beuning PJ
    Biochemistry; 2011 Nov; 50(43):9283-95. PubMed ID: 21970785
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Substrate polarization by residues in delta 5-3-ketosteroid isomerase probed by site-directed mutagenesis and UV resonance Raman spectroscopy.
    Austin JC; Kuliopulos A; Mildvan AS; Spiro TG
    Protein Sci; 1992 Feb; 1(2):259-70. PubMed ID: 1339027
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ultraviolet spectroscopic evidence for decreased motion of the active site tyrosine residue of delta 5-3-ketosteroid isomerase by steroid binding.
    Zhao Q; Li YK; Mildvan AS; Talalay P
    Biochemistry; 1995 May; 34(19):6562-72. PubMed ID: 7756287
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase.
    Kuliopulos A; Mildvan AS; Shortle D; Talalay P
    Biochemistry; 1989 Jan; 28(1):149-59. PubMed ID: 2706241
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutational analysis of the three cysteines and active-site aspartic acid 103 of ketosteroid isomerase from Pseudomonas putida biotype B.
    Kim SW; Joo S; Choi G; Cho HS; Oh BH; Choi KY
    J Bacteriol; 1997 Dec; 179(24):7742-7. PubMed ID: 9401033
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.