BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

364 related articles for article (PubMed ID: 23812586)

  • 1. Structural basis for the inhibition of bacterial multidrug exporters.
    Nakashima R; Sakurai K; Yamasaki S; Hayashi K; Nagata C; Hoshino K; Onodera Y; Nishino K; Yamaguchi A
    Nature; 2013 Aug; 500(7460):102-6. PubMed ID: 23812586
    [TBL] [Abstract][Full Text] [Related]  

  • 2. [Structural Analysis and New Drug Development against Multidrug Efflux Pumps].
    Yamasaki S; Nakashima R; Sakurai K; Yamaguchi A; Nishino K
    Yakugaku Zasshi; 2017; 137(4):377-382. PubMed ID: 28381709
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Spatial Characteristics of the Efflux Pump MexB Determine Inhibitor Binding.
    Yamasaki S; Koga N; Zwama M; Sakurai K; Nakashima R; Yamaguchi A; Nishino K
    Antimicrob Agents Chemother; 2022 Nov; 66(11):e0067222. PubMed ID: 36300935
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
    Sjuts H; Vargiu AV; Kwasny SM; Nguyen ST; Kim HS; Ding X; Ornik AR; Ruggerone P; Bowlin TL; Nikaido H; Pos KM; Opperman TJ
    Proc Natl Acad Sci U S A; 2016 Mar; 113(13):3509-14. PubMed ID: 26976576
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of natural compound inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in silico high-throughput virtual screening and in vitro validation.
    Aparna V; Dineshkumar K; Mohanalakshmi N; Velmurugan D; Hopper W
    PLoS One; 2014; 9(7):e101840. PubMed ID: 25025665
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.
    Murakami S; Nakashima R; Yamashita E; Matsumoto T; Yamaguchi A
    Nature; 2006 Sep; 443(7108):173-9. PubMed ID: 16915237
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Unidirectional peristaltic movement in multisite drug binding pockets of AcrB from molecular dynamics simulations.
    Feng Z; Hou T; Li Y
    Mol Biosyst; 2012 Oct; 8(10):2699-709. PubMed ID: 22825052
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of
    Gervasoni S; Malloci G; Bosin A; Vargiu AV; Zgurskaya HI; Ruggerone P
    Phys Chem Chem Phys; 2022 Jul; 24(27):16566-16575. PubMed ID: 35766032
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
    Plé C; Tam HK; Vieira Da Cruz A; Compagne N; Jiménez-Castellanos JC; Müller RT; Pradel E; Foong WE; Malloci G; Ballée A; Kirchner MA; Moshfegh P; Herledan A; Herrmann A; Deprez B; Willand N; Vargiu AV; Pos KM; Flipo M; Hartkoorn RC
    Nat Commun; 2022 Jan; 13(1):115. PubMed ID: 35013254
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa.
    Sennhauser G; Bukowska MA; Briand C; Grütter MG
    J Mol Biol; 2009 May; 389(1):134-45. PubMed ID: 19361527
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular Modeling of Multidrug Properties of Resistance Nodulation Division (RND) Transporters.
    Cacciotto P; Ramaswamy VK; Malloci G; Ruggerone P; Vargiu AV
    Methods Mol Biol; 2018; 1700():179-219. PubMed ID: 29177832
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure of the AcrAB-TolC multidrug efflux pump.
    Du D; Wang Z; James NR; Voss JE; Klimont E; Ohene-Agyei T; Venter H; Chiu W; Luisi BF
    Nature; 2014 May; 509(7501):512-5. PubMed ID: 24747401
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds.
    Sakurai K; Yamasaki S; Nakao K; Nishino K; Yamaguchi A; Nakashima R
    Sci Rep; 2019 Mar; 9(1):4359. PubMed ID: 30867446
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket.
    Nakashima R; Sakurai K; Yamasaki S; Nishino K; Yamaguchi A
    Nature; 2011 Nov; 480(7378):565-9. PubMed ID: 22121023
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Computer simulations suggest direct and stable tip to tip interaction between the outer membrane channel TolC and the isolated docking domain of the multidrug RND efflux transporter AcrB.
    Schmidt TH; Raunest M; Fischer N; Reith D; Kandt C
    Biochim Biophys Acta; 2016 Jul; 1858(7 Pt A):1419-26. PubMed ID: 27045078
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC.
    Tikhonova EB; Yamada Y; Zgurskaya HI
    Chem Biol; 2011 Apr; 18(4):454-63. PubMed ID: 21513882
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution.
    Chen M; Shi X; Yu Z; Fan G; Serysheva II; Baker ML; Luisi BF; Ludtke SJ; Wang Z
    Structure; 2022 Jan; 30(1):107-113.e3. PubMed ID: 34506732
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa.
    Mehla J; Malloci G; Mansbach R; López CA; Tsivkovski R; Haynes K; Leus IV; Grindstaff SB; Cascella RH; D'Cunha N; Herndon L; Hengartner NW; Margiotta E; Atzori A; Vargiu AV; Manrique PD; Walker JK; Lomovskaya O; Ruggerone P; Gnanakaran S; Rybenkov VV; Zgurskaya HI
    mBio; 2021 Jan; 12(1):. PubMed ID: 33468691
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB.
    Krishnamoorthy G; Tikhonova EB; Zgurskaya HI
    J Bacteriol; 2008 Jan; 190(2):691-8. PubMed ID: 18024521
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors.
    Vargiu AV; Ruggerone P; Opperman TJ; Nguyen ST; Nikaido H
    Antimicrob Agents Chemother; 2014 Oct; 58(10):6224-34. PubMed ID: 25114133
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.