These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 2383580)

  • 1. Reversible covalent binding of peptide nitriles to papain.
    Hanzlik RP; Zygmunt J; Moon JB
    Biochim Biophys Acta; 1990 Jul; 1035(1):62-70. PubMed ID: 2383580
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Reversible binding of peptide aldehydes to papain. Structure-activity relationships.
    Hanzlik RP; Jacober SP; Zygmunt J
    Biochim Biophys Acta; 1991 Jan; 1073(1):33-42. PubMed ID: 1991144
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of papain by nitriles: mechanistic studies using NMR and kinetic measurements.
    Liang TC; Abeles RH
    Arch Biochem Biophys; 1987 Feb; 252(2):626-34. PubMed ID: 3813553
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Peptide aldehydes and nitriles as transition state analog inhibitors of cysteine proteases.
    Dufour E; Storer AC; Ménard R
    Biochemistry; 1995 Jul; 34(28):9136-43. PubMed ID: 7619812
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P1-P2 amide bond into a two-protonic-state reactivity probe.
    Brocklehurst K; Kowlessur D; Patel G; Templeton W; Quigley K; Thomas EW; Wharton CW; Willenbrock F; Szawelski RJ
    Biochem J; 1988 Mar; 250(3):761-72. PubMed ID: 2839145
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Engineering nitrile hydratase activity into a cysteine protease by a single mutation.
    Dufour E; Storer AC; Ménard R
    Biochemistry; 1995 Dec; 34(50):16382-8. PubMed ID: 8845364
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Protein engineering of nitrile hydratase activity of papain: molecular dynamics study of a mutant and wild-type enzyme.
    Reddy SY; Kahn K; Zheng YJ; Bruice TC
    J Am Chem Soc; 2002 Nov; 124(44):12979-90. PubMed ID: 12405824
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of ligand homologation and ligand reactivity on the apparent kinetic specificity of papain.
    Liu S; Hanzlik RP
    Biochim Biophys Acta; 1995 Jul; 1250(1):43-8. PubMed ID: 7612652
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites.
    Berti PJ; Faerman CH; Storer AC
    Biochemistry; 1991 Feb; 30(5):1394-402. PubMed ID: 1991120
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Is strong hydrogen bonding in the transition state enough to account for the observed rate acceleration in a mutant of papain?
    Zheng YJ; Bruice TC
    Proc Natl Acad Sci U S A; 1997 Apr; 94(9):4285-8. PubMed ID: 9113981
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.
    Templeton W; Kowlessur D; Thomas EW; Topham CM; Brocklehurst K
    Biochem J; 1990 Mar; 266(3):645-51. PubMed ID: 2327953
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain.
    Kowlessur D; Topham CM; Thomas EW; O'Driscoll M; Templeton W; Brocklehurst K
    Biochem J; 1989 Mar; 258(3):755-64. PubMed ID: 2730566
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides.
    Kowlessur D; Thomas EW; Topham CM; Templeton W; Brocklehurst K
    Biochem J; 1990 Mar; 266(3):653-60. PubMed ID: 2327954
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Active and inactive forms of the transition-state analog protease inhibitor leupeptin: explanation of the observed slow binding of leupeptin to cathepsin B and papain.
    Schultz RM; Varma-Nelson P; Ortiz R; Kozlowski KA; Orawski AT; Pagast P; Frankfater A
    J Biol Chem; 1989 Jan; 264(3):1497-507. PubMed ID: 2912969
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe studies targeted on the catalytic-site thiol group and its immediate microenvironment.
    Salih E; Malthouse JP; Kowlessur D; Jarvis M; O'Driscoll M; Brocklehurst K
    Biochem J; 1987 Oct; 247(1):181-93. PubMed ID: 2825655
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The contribution of intermolecular hydrogen bonding to the kinetic specificity of papain.
    Liu S; Hanzlik RP
    Biochim Biophys Acta; 1993 Nov; 1158(3):264-72. PubMed ID: 8251526
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Kinetic solvent isotope effects on the deacylation of specific acyl-papains. Proton inventory studies on the papain-catalysed hydrolyses of specific ester substrates: analysis of possible transition state structures.
    Szawelski RJ; Wharton CW
    Biochem J; 1981 Dec; 199(3):681-92. PubMed ID: 6280675
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enthalpy and entropy of hippuraldehyde hydration and binding to papain.
    Moon JB; Hanzlik RP
    Biochim Biophys Acta; 1987 Jul; 914(1):1-5. PubMed ID: 3607058
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain.
    Patel M; Kayani IS; Templeton W; Mellor GW; Thomas EW; Brocklehurst K
    Biochem J; 1992 Nov; 287 ( Pt 3)(Pt 3):881-9. PubMed ID: 1445247
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evidence that binding to the s2-subsite of papain may be coupled with catalytically relevant structural change involving the cysteine-25-histidine-159 diad. Kinetics of the reaction of papain with a two-protonic-state reactivity probe containing a hydrophobic side chain.
    Brocklehurst K; Malthouse JP; Shipton M
    Biochem J; 1979 Nov; 183(2):223-31. PubMed ID: 43129
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.