BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 23836614)

  • 1. Small-molecule procaspase activators identified using fluorescence polarization.
    Vickers CJ; González-Páez GE; Umotoy JC; Cayanan-Garrett C; Brown SJ; Wolan DW
    Chembiochem; 2013 Aug; 14(12):1419-22. PubMed ID: 23836614
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays.
    Pereira C; Lopes-Rodrigues V; Coutinho I; Neves MP; Lima RT; Pinto M; Cidade H; Vasconcelos MH; Saraiva L
    Eur J Pharm Sci; 2014 Apr; 54():8-16. PubMed ID: 24398107
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of small-molecule enzyme activators by activity-based protein profiling.
    Kok BP; Ghimire S; Kim W; Chatterjee S; Johns T; Kitamura S; Eberhardt J; Ogasawara D; Xu J; Sukiasyan A; Kim SM; Godio C; Bittencourt JM; Cameron M; Galmozzi A; Forli S; Wolan DW; Cravatt BF; Boger DL; Saez E
    Nat Chem Biol; 2020 Sep; 16(9):997-1005. PubMed ID: 32514184
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of chaulmoogric acid as a small molecule activator of protein phosphatase 5.
    Cher C; Tremblay MH; Barber JR; Chung Ng S; Zhang B
    Appl Biochem Biotechnol; 2010 Mar; 160(5):1450-9. PubMed ID: 19404779
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Small-molecule activators of a proenzyme.
    Wolan DW; Zorn JA; Gray DC; Wells JA
    Science; 2009 Nov; 326(5954):853-8. PubMed ID: 19892984
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.
    Zhao G; Iyengar RR; Judd AS; Cool B; Chiou W; Kifle L; Frevert E; Sham H; Kym PR
    Bioorg Med Chem Lett; 2007 Jun; 17(12):3254-7. PubMed ID: 17451949
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The potential for caspases in drug discovery.
    MacKenzie SH; Schipper JL; Clark AC
    Curr Opin Drug Discov Devel; 2010 Sep; 13(5):568-76. PubMed ID: 20812148
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of promiscuous small molecule activators in high-throughput enzyme activation screens.
    Goode DR; Totten RK; Heeres JT; Hergenrother PJ
    J Med Chem; 2008 Apr; 51(8):2346-9. PubMed ID: 18366176
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Direct small-molecule kinase activation: Novel approaches for a new era of drug discovery.
    Simpson GL; Hughes JA; Washio Y; Bertrand SM
    Curr Opin Drug Discov Devel; 2009 Sep; 12(5):585-96. PubMed ID: 19736618
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Assay development and high-throughput screening of small molecular c-Abl kinase activators.
    Cottom J; Hofmann G; Siegfried B; Yang J; Zhang H; Yi T; Ho TF; Quinn C; Wang DY; Johanson K; Ames RS; Li H
    J Biomol Screen; 2011 Jan; 16(1):53-64. PubMed ID: 20938045
    [TBL] [Abstract][Full Text] [Related]  

  • 11. An in silico mechanistic insight into HDAC8 activation facilitates the discovery of new small-molecule activators.
    Du J; Li W; Liu B; Zhang Y; Yu J; Hou X; Fang H
    Bioorg Med Chem; 2020 Aug; 28(16):115607. PubMed ID: 32690262
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Modulators of intestinal alkaline phosphatase.
    Bobkova EV; Kiffer-Moreira T; Sergienko EA
    Methods Mol Biol; 2013; 1053():135-44. PubMed ID: 23860652
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and Assay of SIRT1-Activating Compounds.
    Dai H; Ellis JL; Sinclair DA; Hubbard BP
    Methods Enzymol; 2016; 574():213-244. PubMed ID: 27423864
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery, synthesis, and structure-activity relationships of 20(S)-protopanaxadiol (PPD) derivatives as a novel class of AMPKα2β1γ1 activators.
    Liu J; Chen D; Liu P; He M; Li J; Li J; Hu L
    Eur J Med Chem; 2014 May; 79():340-9. PubMed ID: 24747289
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1.
    Kawarski M; Hagerman TK; Karver CE
    Chem Biol Drug Des; 2015 Nov; 86(5):1049-54. PubMed ID: 25871734
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation.
    Zorn JA; Wille H; Wolan DW; Wells JA
    J Am Chem Soc; 2011 Dec; 133(49):19630-3. PubMed ID: 22066605
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
    Clausse V; Tao D; Debnath S; Fang Y; Tagad HD; Wang Y; Sun H; LeClair CA; Mazur SJ; Lane K; Shi ZD; Vasalatiy O; Eells R; Baker LK; Henderson MJ; Webb MR; Shen M; Hall MD; Appella E; Appella DH; Coussens NP
    J Biol Chem; 2019 Nov; 294(46):17654-17668. PubMed ID: 31481464
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.
    Samatov TR; Wolf A; Odenwälder P; Bessonov S; Deraeve C; Bon RS; Waldmann H; Lührmann R
    Chembiochem; 2012 Mar; 13(5):640-4. PubMed ID: 22334518
    [No Abstract]   [Full Text] [Related]  

  • 19. Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
    Erlanson DA; Arndt JW; Cancilla MT; Cao K; Elling RA; English N; Friedman J; Hansen SK; Hession C; Joseph I; Kumaravel G; Lee WC; Lind KE; McDowell RS; Miatkowski K; Nguyen C; Nguyen TB; Park S; Pathan N; Penny DM; Romanowski MJ; Scott D; Silvian L; Simmons RL; Tangonan BT; Yang W; Sun L
    Bioorg Med Chem Lett; 2011 May; 21(10):3078-83. PubMed ID: 21459573
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tailoring small molecules for an allosteric site on procaspase-6.
    Murray J; Giannetti AM; Steffek M; Gibbons P; Hearn BR; Cohen F; Tam C; Pozniak C; Bravo B; Lewcock J; Jaishankar P; Ly CQ; Zhao X; Tang Y; Chugha P; Arkin MR; Flygare J; Renslo AR
    ChemMedChem; 2014 Jan; 9(1):73-7, 2. PubMed ID: 24259468
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.