BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

60 related articles for article (PubMed ID: 23845281)

  • 1. Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor.
    Watanabe K; Kakefuda A; Yasuda M; Enjo K; Kikuchi A; Furutani T; Naritomi Y; Otsuka Y; Okada M; Ohta M
    Bioorg Med Chem; 2013 Sep; 21(17):5261-70. PubMed ID: 23845281
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
    Liedtke AJ; Adeniji AO; Chen M; Byrns MC; Jin Y; Christianson DW; Marnett LJ; Penning TM
    J Med Chem; 2013 Mar; 56(6):2429-46. PubMed ID: 23432095
    [TBL] [Abstract][Full Text] [Related]  

  • 3. AKR1C3 as a target in castrate resistant prostate cancer.
    Adeniji AO; Chen M; Penning TM
    J Steroid Biochem Mol Biol; 2013 Sep; 137():136-49. PubMed ID: 23748150
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancer.
    Barnard M; Quanson JL; Mostaghel E; Pretorius E; Snoep JL; Storbeck KH
    J Steroid Biochem Mol Biol; 2018 Oct; 183():192-201. PubMed ID: 29936123
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer.
    Himura R; Kawano S; Nagata Y; Kawai M; Ota A; Kudo Y; Yoshino Y; Fujimoto N; Miyamoto H; Endo S; Ikari A
    Chem Biol Interact; 2024 Jan; 388():110840. PubMed ID: 38122923
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.
    Pippione AC; Kovachka S; Vigato C; Bertarini L; Mannella I; Sainas S; Rolando B; Denasio E; Piercy-Mycock H; Romalho L; Salladini E; Adinolfi S; Zonari D; Peraldo-Neia C; Chiorino G; Passoni A; Mirza OA; Frydenvang K; Pors K; Lolli ML; Spyrakis F; Oliaro-Bosso S; Boschi D
    Eur J Med Chem; 2024 Mar; 268():116193. PubMed ID: 38364714
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
    Hendriks CM; Penning TM; Zang T; Wiemuth D; Gründer S; Sanhueza IA; Schoenebeck F; Bolm C
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4437-40. PubMed ID: 26372652
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer.
    Park S; Song CS; Lin CL; Jiang S; Osmulski PA; Wang CM; Marck BT; Matsumoto AM; Morrissey C; Gaczynska ME; Chen Y; Mostaghel EA; Chatterjee B
    Endocrinology; 2020 Feb; 161(2):. PubMed ID: 31894239
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular docking, 3D-QSAR and simulation studies for identifying pharmacophoric features of indole derivatives as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) inhibitors.
    Kulkarni S; Singh Y; Biharee A; Bhatia N; Monga V; Thareja S
    J Biomol Struct Dyn; 2023; 41(22):12668-12685. PubMed ID: 36744535
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 catalyzes the activation of testosterone.
    Oestlund I; Snoep J; Schiffer L; Wabitsch M; Arlt W; Storbeck KH
    J Steroid Biochem Mol Biol; 2024 Feb; 236():106436. PubMed ID: 38035948
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model.
    Maddeboina K; Jonnalagadda SK; Morsy A; Duan L; Chhonker YS; Murry DJ; Penning TM; Trippier PC
    J Med Chem; 2023 Jul; 66(14):9894-9915. PubMed ID: 37428858
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel aldo-keto reductase 1C3 inhibitor affects androgen metabolism but not ovarian function in healthy women: a phase 1 study.
    Gashaw I; Reif S; Wiesinger H; Kaiser A; Zollmann FS; Scheerans C; Grevel J; Piraino P; Seidel H; Peters M; Rottmann A; Rohde B; Arlt W; Hilpert J
    Eur J Endocrinol; 2023 Jul; 188(7):578-591. PubMed ID: 37306288
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Steroid hormone transforming aldo-keto reductases and cancer.
    Penning TM; Byrns MC
    Ann N Y Acad Sci; 2009 Feb; 1155():33-42. PubMed ID: 19250190
    [TBL] [Abstract][Full Text] [Related]  

  • 14. AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies.
    Li M; Zhang L; Yu J; Wang X; Cheng L; Ma Z; Chen X; Wang L; Goh BC
    Front Pharmacol; 2024; 15():1378292. PubMed ID: 38523637
    [TBL] [Abstract][Full Text] [Related]  

  • 15. AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3β,17β-Diol.
    Detlefsen AJ; Mesaros CA; Duan L; Penning TM
    Cancer Res Commun; 2023 Sep; 3(9):1888-1898. PubMed ID: 37772993
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure determination, molecular docking, and molecular dynamics of arylal dimedones as potential inhibitors for castrate-resistant prostate cancer.
    R C; Kiran KS; Chaithanya MS; M A
    Biotechnol Appl Biochem; 2023 Dec; 70(6):1794-1805. PubMed ID: 37279111
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and characterization of targeted 17β-hydroxysteroid dehydrogenase type 7 inhibitors.
    Sancéau JY; Maltais R; Zhou M; Lin SX; Poirier D
    J Steroid Biochem Mol Biol; 2024 May; ():106544. PubMed ID: 38754521
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader.
    Carmona AV; Jonnalagadda S; Case AM; Maddeboina K; Jonnalagadda SK; Dow LF; Duan L; Penning TM; Trippier PC
    Commun Chem; 2024 Apr; 7(1):95. PubMed ID: 38684887
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals.
    Plavša JJ; Řezáčová P; Kugler M; Pachl P; Brynda J; Voburka Z; Ćelić A; Petri ET; Škerlová J
    Acta Crystallogr F Struct Biol Commun; 2018 May; 74(Pt 5):300-306. PubMed ID: 29717998
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction.
    Mayr F; Möller G; Garscha U; Fischer J; Rodríguez Castaño P; Inderbinen SG; Temml V; Waltenberger B; Schwaiger S; Hartmann RW; Gege C; Martens S; Odermatt A; Pandey AV; Werz O; Adamski J; Stuppner H; Schuster D
    Int J Mol Sci; 2020 Sep; 21(19):. PubMed ID: 32993084
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 3.