These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 23865807)

  • 41. The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators.
    Botev A; Munter LM; Wenzel R; Richter L; Althoff V; Ismer J; Gerling U; Weise C; Koksch B; Hildebrand PW; Bittl R; Multhaup G
    Biochemistry; 2011 Feb; 50(5):828-35. PubMed ID: 21186781
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
    Richter L; Munter LM; Ness J; Hildebrand PW; Dasari M; Unterreitmeier S; Bulic B; Beyermann M; Gust R; Reif B; Weggen S; Langosch D; Multhaup G
    Proc Natl Acad Sci U S A; 2010 Aug; 107(33):14597-602. PubMed ID: 20679249
    [TBL] [Abstract][Full Text] [Related]  

  • 43. The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.
    Pester O; Barrett PJ; Hornburg D; Hornburg P; Pröbstle R; Widmaier S; Kutzner C; Dürrbaum M; Kapurniotu A; Sanders CR; Scharnagl C; Langosch D
    J Am Chem Soc; 2013 Jan; 135(4):1317-29. PubMed ID: 23265086
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain.
    Castro MA; Parson KF; Beg I; Wilkinson MC; Nurmakova K; Levesque I; Voehler MW; Wolfe MS; Ruotolo BT; Sanders CR
    J Biol Chem; 2022 Apr; 298(4):101792. PubMed ID: 35247387
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Bacterial and cell-free production of APP671-726 containing amyloid precursor protein transmembrane and metal-binding domains.
    Bocharova OV; Urban AS; Nadezhdin KD; Bocharov EV; Arseniev AS
    Biochemistry (Mosc); 2013 Nov; 78(11):1263-71. PubMed ID: 24460940
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition.
    Oikawa N; Fabiano M; Müller UC; Walter J
    Biochem Biophys Res Commun; 2021 Sep; 570():137-142. PubMed ID: 34280617
    [TBL] [Abstract][Full Text] [Related]  

  • 48. X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
    King GD; Cherian K; Turner RS
    J Neurochem; 2004 Feb; 88(4):971-82. PubMed ID: 14756819
    [TBL] [Abstract][Full Text] [Related]  

  • 49. The transmembrane amyloid precursor C99 protein exhibits non-specific interaction with tau.
    Britton RJ; Hutchison JM; Sanders CR
    Biochem Biophys Res Commun; 2021 Oct; 576():48-52. PubMed ID: 34481234
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Defining the minimum substrate and charge recognition model of gamma-secretase.
    Yan Y; Xu TH; Melcher K; Xu HE
    Acta Pharmacol Sin; 2017 Oct; 38(10):1412-1424. PubMed ID: 28414207
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Specific Binding of Cholesterol to C99 Domain of Amyloid Precursor Protein Depends Critically on Charge State of Protein.
    Panahi A; Bandara A; Pantelopulos GA; Dominguez L; Straub JE
    J Phys Chem Lett; 2016 Sep; 7(18):3535-41. PubMed ID: 27525349
    [TBL] [Abstract][Full Text] [Related]  

  • 52. β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.
    Hu Y; Kienlen-Campard P; Tang TC; Perrin F; Opsomer R; Decock M; Pan X; Octave JN; Constantinescu SN; Smith SO
    Sci Rep; 2017 Dec; 7(1):17159. PubMed ID: 29215043
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Mechanism of intramembrane cleavage of alcadeins by γ-secretase.
    Piao Y; Kimura A; Urano S; Saito Y; Taru H; Yamamoto T; Hata S; Suzuki T
    PLoS One; 2013; 8(4):e62431. PubMed ID: 23658629
    [TBL] [Abstract][Full Text] [Related]  

  • 54. The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted.
    Grziwa B; Grimm MO; Masters CL; Beyreuther K; Hartmann T; Lichtenthaler SF
    J Biol Chem; 2003 Feb; 278(9):6803-8. PubMed ID: 12454010
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Cholesterol as a co-solvent and a ligand for membrane proteins.
    Song Y; Kenworthy AK; Sanders CR
    Protein Sci; 2014 Jan; 23(1):1-22. PubMed ID: 24155031
    [TBL] [Abstract][Full Text] [Related]  

  • 56. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.
    Sala Frigerio C; Kukar TL; Fauq A; Engel PC; Golde TE; Walsh DM
    Biochemistry; 2009 Nov; 48(46):10894-904. PubMed ID: 19821615
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.
    Kukar TL; Ladd TB; Robertson P; Pintchovski SA; Moore B; Bann MA; Ren Z; Jansen-West K; Malphrus K; Eggert S; Maruyama H; Cottrell BA; Das P; Basi GS; Koo EH; Golde TE
    J Biol Chem; 2011 Nov; 286(46):39804-12. PubMed ID: 21868378
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.
    Eggert S; Midthune B; Cottrell B; Koo EH
    J Biol Chem; 2009 Oct; 284(42):28943-52. PubMed ID: 19596858
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Elucidation of the interactions between C99, presenilin, and nicastrin by the split-ubiquitin assay.
    Goo JH; Park WJ
    DNA Cell Biol; 2004 Jan; 23(1):59-65. PubMed ID: 14965473
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Structural Modeling of γ-Secretase Aβ
    Hitzenberger M; Zacharias M
    ACS Chem Neurosci; 2019 Mar; 10(3):1826-1840. PubMed ID: 30638370
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 15.