257 related articles for article (PubMed ID: 23867462)
1. Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.
Shelkovnikova TA; Peters OM; Deykin AV; Connor-Robson N; Robinson H; Ustyugov AA; Bachurin SO; Ermolkevich TG; Goldman IL; Sadchikova ER; Kovrazhkina EA; Skvortsova VI; Ling SC; Da Cruz S; Parone PA; Buchman VL; Ninkina NN
J Biol Chem; 2013 Aug; 288(35):25266-25274. PubMed ID: 23867462
[TBL] [Abstract][Full Text] [Related]
2. FUS(1-359) transgenic mice as a model of ALS: pathophysiological and molecular aspects of the proteinopathy.
Funikov SY; Rezvykh AP; Mazin PV; Morozov AV; Maltsev AV; Chicheva MM; Vikhareva EA; Evgen'ev MB; Ustyugov AA
Neurogenetics; 2018 Aug; 19(3):189-204. PubMed ID: 29982879
[TBL] [Abstract][Full Text] [Related]
3. Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.
Scekic-Zahirovic J; Oussini HE; Mersmann S; Drenner K; Wagner M; Sun Y; Allmeroth K; Dieterlé S; Sinniger J; Dirrig-Grosch S; René F; Dormann D; Haass C; Ludolph AC; Lagier-Tourenne C; Storkebaum E; Dupuis L
Acta Neuropathol; 2017 Jun; 133(6):887-906. PubMed ID: 28243725
[TBL] [Abstract][Full Text] [Related]
4. Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration.
Zhao B; Cowan CM; Coutts JA; Christy DD; Saraph A; Hsueh SCC; Plotkin SS; Mackenzie IR; Kaplan JM; Cashman NR
Acta Neuropathol Commun; 2023 Dec; 11(1):200. PubMed ID: 38111057
[TBL] [Abstract][Full Text] [Related]
5. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.
Shiihashi G; Ito D; Yagi T; Nihei Y; Ebine T; Suzuki N
Brain; 2016 Sep; 139(Pt 9):2380-94. PubMed ID: 27368346
[TBL] [Abstract][Full Text] [Related]
6. Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.
Robinson HK; Deykin AV; Bronovitsky EV; Ovchinnikov RK; Ustyugov AA; Shelkovnikova TA; Kukharsky MS; Ermolkevich TG; Goldman IL; Sadchikova ER; Kovrazhkina EA; Bachurin SO; Buchman VL; Ninkina NN
Amyotroph Lateral Scler Frontotemporal Degener; 2015; 16(5-6):402-9. PubMed ID: 25991062
[TBL] [Abstract][Full Text] [Related]
7. "STRESSED OUT": The role of FUS and TDP-43 in amyotrophic lateral sclerosis.
Aksoy YA; Deng W; Stoddart J; Chung R; Guillemin G; Cole NJ; Neely GG; Hesselson D
Int J Biochem Cell Biol; 2020 Sep; 126():105821. PubMed ID: 32758633
[TBL] [Abstract][Full Text] [Related]
8. Human TDP-43 and FUS selectively affect motor neuron maturation and survival in a murine cell model of ALS by non-cell-autonomous mechanisms.
Wächter N; Storch A; Hermann A
Amyotroph Lateral Scler Frontotemporal Degener; 2015; 16(7-8):431-41. PubMed ID: 26174443
[TBL] [Abstract][Full Text] [Related]
9. Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Verbeeck C; Deng Q; Dejesus-Hernandez M; Taylor G; Ceballos-Diaz C; Kocerha J; Golde T; Das P; Rademakers R; Dickson DW; Kukar T
Mol Neurodegener; 2012 Oct; 7():53. PubMed ID: 23046583
[TBL] [Abstract][Full Text] [Related]
10. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
Naumann M; Pal A; Goswami A; Lojewski X; Japtok J; Vehlow A; Naujock M; Günther R; Jin M; Stanslowsky N; Reinhardt P; Sterneckert J; Frickenhaus M; Pan-Montojo F; Storkebaum E; Poser I; Freischmidt A; Weishaupt JH; Holzmann K; Troost D; Ludolph AC; Boeckers TM; Liebau S; Petri S; Cordes N; Hyman AA; Wegner F; Grill SW; Weis J; Storch A; Hermann A
Nat Commun; 2018 Jan; 9(1):335. PubMed ID: 29362359
[TBL] [Abstract][Full Text] [Related]
11. U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish.
Yu Y; Chi B; Xia W; Gangopadhyay J; Yamazaki T; Winkelbauer-Hurt ME; Yin S; Eliasse Y; Adams E; Shaw CE; Reed R
Nucleic Acids Res; 2015 Mar; 43(6):3208-18. PubMed ID: 25735748
[TBL] [Abstract][Full Text] [Related]
12. Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations.
Bäumer D; Hilton D; Paine SM; Turner MR; Lowe J; Talbot K; Ansorge O
Neurology; 2010 Aug; 75(7):611-8. PubMed ID: 20668261
[TBL] [Abstract][Full Text] [Related]
13. Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
Pokrishevsky E; Grad LI; Yousefi M; Wang J; Mackenzie IR; Cashman NR
PLoS One; 2012; 7(4):e35050. PubMed ID: 22493728
[TBL] [Abstract][Full Text] [Related]
14. Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
Ikenaka K; Ishigaki S; Iguchi Y; Kawai K; Fujioka Y; Yokoi S; Abdelhamid RF; Nagano S; Mochizuki H; Katsuno M; Sobue G
J Neuropathol Exp Neurol; 2020 Apr; 79(4):370-377. PubMed ID: 32142134
[TBL] [Abstract][Full Text] [Related]
15. Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS.
Xia R; Liu Y; Yang L; Gal J; Zhu H; Jia J
Mol Neurodegener; 2012 Mar; 7():10. PubMed ID: 22443542
[TBL] [Abstract][Full Text] [Related]
16. RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.
Daigle JG; Lanson NA; Smith RB; Casci I; Maltare A; Monaghan J; Nichols CD; Kryndushkin D; Shewmaker F; Pandey UB
Hum Mol Genet; 2013 Mar; 22(6):1193-205. PubMed ID: 23257289
[TBL] [Abstract][Full Text] [Related]
17. Cytoplasmic aggregation of mutant FUS causes multistep RNA splicing perturbations in the course of motor neuron pathology.
Rezvykh AP; Ustyugov AA; Chaprov KD; Teterina EV; Nebogatikov VO; Spasskaya DS; Evgen'ev MB; Morozov AV; Funikov SY
Nucleic Acids Res; 2023 Jun; 51(11):5810-5830. PubMed ID: 37115004
[TBL] [Abstract][Full Text] [Related]
18. Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm.
Shelkovnikova TA; Robinson HK; Connor-Robson N; Buchman VL
Cell Cycle; 2013 Oct; 12(19):3194-202. PubMed ID: 24013423
[TBL] [Abstract][Full Text] [Related]
19. Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.
Pelaez MC; Desmeules A; Gelon PA; Glasson B; Marcadet L; Rodgers A; Phaneuf D; Pozzi S; Dutchak PA; Julien JP; Sephton CF
Acta Neuropathol Commun; 2023 Nov; 11(1):182. PubMed ID: 37974279
[TBL] [Abstract][Full Text] [Related]
20. Low Level of Expression of C-Terminally Truncated Human FUS Causes Extensive Changes in the Spinal Cord Transcriptome of Asymptomatic Transgenic Mice.
Lysikova EA; Funikov S; Rezvykh AP; Chaprov KD; Kukharsky MS; Ustyugov A; Deykin AV; Flyamer IM; Boyle S; Bachurin SO; Ninkina N; Buchman VL
Neurochem Res; 2020 May; 45(5):1168-1179. PubMed ID: 32157564
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]