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2. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Yang Q; Inoki K; Kim E; Guan KL Proc Natl Acad Sci U S A; 2006 May; 103(18):6811-6. PubMed ID: 16627617 [TBL] [Abstract][Full Text] [Related]
3. The Drosophila platelet-derived growth factor and vascular endothelial growth factor-receptor related (Pvr) protein ligands Pvf2 and Pvf3 control hemocyte viability and invasive migration. Parsons B; Foley E J Biol Chem; 2013 Jul; 288(28):20173-83. PubMed ID: 23737520 [TBL] [Abstract][Full Text] [Related]
5. Functional assessment of TSC2 variants identified in individuals with tuberous sclerosis complex. Hoogeveen-Westerveld M; Ekong R; Povey S; Mayer K; Lannoy N; Elmslie F; Bebin M; Dies K; Thompson C; Sparagana SP; Davies P; van Eeghen AM; Thiele EA; van den Ouweland A; Halley D; Nellist M Hum Mutat; 2013 Jan; 34(1):167-75. PubMed ID: 22903760 [TBL] [Abstract][Full Text] [Related]
6. mTORC2 is required for proliferation and survival of TSC2-null cells. Goncharova EA; Goncharov DA; Li H; Pimtong W; Lu S; Khavin I; Krymskaya VP Mol Cell Biol; 2011 Jun; 31(12):2484-98. PubMed ID: 21482669 [TBL] [Abstract][Full Text] [Related]
7. Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models. Gökmen-Polar Y; Liu Y; Toroni RA; Sanders KL; Mehta R; Badve S; Rommel C; Sledge GW Breast Cancer Res Treat; 2012 Dec; 136(3):673-82. PubMed ID: 23085766 [TBL] [Abstract][Full Text] [Related]
8. Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish. Kim SH; Kowalski ML; Carson RP; Bridges LR; Ess KC Dis Model Mech; 2013 Jul; 6(4):925-33. PubMed ID: 23580196 [TBL] [Abstract][Full Text] [Related]
9. Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis. Zech R; Kiontke S; Mueller U; Oeckinghaus A; Kümmel D J Biol Chem; 2016 Sep; 291(38):20008-20. PubMed ID: 27493206 [TBL] [Abstract][Full Text] [Related]
10. The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits. Hoogeveen-Westerveld M; van Unen L; van den Ouweland A; Halley D; Hoogeveen A; Nellist M BMC Biochem; 2012 Sep; 13():18. PubMed ID: 23006675 [TBL] [Abstract][Full Text] [Related]
11. Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling. Atochina-Vasserman EN; Goncharov DA; Volgina AV; Milavec M; James ML; Krymskaya VP Am J Respir Cell Mol Biol; 2013 Nov; 49(5):704-9. PubMed ID: 23947572 [TBL] [Abstract][Full Text] [Related]
12. The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. Wildonger J; Jan LY; Jan YN Genes Dev; 2008 Sep; 22(18):2447-53. PubMed ID: 18794342 [TBL] [Abstract][Full Text] [Related]
13. Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts. Goncharova EA; James ML; Kudryashova TV; Goncharov DA; Krymskaya VP PLoS One; 2014; 9(10):e111476. PubMed ID: 25360538 [TBL] [Abstract][Full Text] [Related]
14. Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growth. Kim M; Lee JH Int J Mol Sci; 2015 Mar; 16(4):7015-26. PubMed ID: 25826530 [TBL] [Abstract][Full Text] [Related]
15. Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer. Mrozek EM; Bajaj V; Guo Y; Malinowska IA; Zhang J; Kwiatkowski DJ PLoS One; 2021; 16(4):e0248380. PubMed ID: 33891611 [TBL] [Abstract][Full Text] [Related]
16. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Demetriades C; Doumpas N; Teleman AA Cell; 2014 Feb; 156(4):786-99. PubMed ID: 24529380 [TBL] [Abstract][Full Text] [Related]
17. Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation. Prabowo AS; Anink JJ; Lammens M; Nellist M; van den Ouweland AM; Adle-Biassette H; Sarnat HB; Flores-Sarnat L; Crino PB; Aronica E Brain Pathol; 2013 Jan; 23(1):45-59. PubMed ID: 22805177 [TBL] [Abstract][Full Text] [Related]
18. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia. Wolff NC; Vega-Rubin-de-Celis S; Xie XJ; Castrillon DH; Kabbani W; Brugarolas J Mol Cell Biol; 2011 May; 31(9):1870-84. PubMed ID: 21383064 [TBL] [Abstract][Full Text] [Related]
19. Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes. Miyazaki M; McCarthy JJ; Esser KA FEBS J; 2010 May; 277(9):2180-91. PubMed ID: 20412061 [TBL] [Abstract][Full Text] [Related]
20. Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. Zeng LH; Rensing NR; Zhang B; Gutmann DH; Gambello MJ; Wong M Hum Mol Genet; 2011 Feb; 20(3):445-54. PubMed ID: 21062901 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]