237 related articles for article (PubMed ID: 23884424)
1. Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.
Zheng H; Li S; Hsu P; Qu CK
J Biol Chem; 2013 Sep; 288(36):25727-25738. PubMed ID: 23884424
[TBL] [Abstract][Full Text] [Related]
2. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
Xu D; Liu X; Yu WM; Meyerson HJ; Guo C; Gerson SL; Qu CK
J Exp Med; 2011 Sep; 208(10):1977-88. PubMed ID: 21930766
[TBL] [Abstract][Full Text] [Related]
3. Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.
Xu D; Zheng H; Yu WM; Qu CK
PLoS One; 2013; 8(5):e63152. PubMed ID: 23675459
[TBL] [Abstract][Full Text] [Related]
4. SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.
Schneeberger VE; Luetteke N; Ren Y; Berns H; Chen L; Foroutan P; Martinez GV; Haura EB; Chen J; Coppola D; Wu J
Carcinogenesis; 2014 Aug; 35(8):1717-25. PubMed ID: 24480804
[TBL] [Abstract][Full Text] [Related]
5. Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
Zheng H; Yu WM; Waclaw RR; Kontaridis MI; Neel BG; Qu CK
Sci Signal; 2018 Mar; 11(522):. PubMed ID: 29559584
[TBL] [Abstract][Full Text] [Related]
6. The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β-catenin signaling pathway.
Zhang Q; Li Y; Zhao R; Wang X; Fan C; Xu Y; Liu Y; Li J; Wang S
Mol Carcinog; 2018 May; 57(5):619-628. PubMed ID: 29323748
[TBL] [Abstract][Full Text] [Related]
7. Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies.
Yu B; Liu W; Yu WM; Loh ML; Alter S; Guvench O; Mackerell AD; Tang LD; Qu CK
Mol Cancer Ther; 2013 Sep; 12(9):1738-48. PubMed ID: 23825065
[TBL] [Abstract][Full Text] [Related]
8. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
Liu X; Zheng H; Li X; Wang S; Meyerson HJ; Yang W; Neel BG; Qu CK
Proc Natl Acad Sci U S A; 2016 Jan; 113(4):984-9. PubMed ID: 26755576
[TBL] [Abstract][Full Text] [Related]
9. Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
Liu W; Yu B; Xu G; Xu WR; Loh ML; Tang LD; Qu CK
J Med Chem; 2013 Sep; 56(18):7212-21. PubMed ID: 23957426
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.
Liu W; Yu WM; Zhang J; Chan RJ; Loh ML; Zhang Z; Bunting KD; Qu CK
Leukemia; 2017 Jun; 31(6):1415-1422. PubMed ID: 27840422
[TBL] [Abstract][Full Text] [Related]
11. A suggested role for mitochondria in Noonan syndrome.
Lee I; Pecinova A; Pecina P; Neel BG; Araki T; Kucherlapati R; Roberts AE; Hüttemann M
Biochim Biophys Acta; 2010 Feb; 1802(2):275-83. PubMed ID: 19835954
[TBL] [Abstract][Full Text] [Related]
12. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Bentires-Alj M; Paez JG; David FS; Keilhack H; Halmos B; Naoki K; Maris JM; Richardson A; Bardelli A; Sugarbaker DJ; Richards WG; Du J; Girard L; Minna JD; Loh ML; Fisher DE; Velculescu VE; Vogelstein B; Meyerson M; Sellers WR; Neel BG
Cancer Res; 2004 Dec; 64(24):8816-20. PubMed ID: 15604238
[TBL] [Abstract][Full Text] [Related]
13. A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.
Romero C; Lambert LJ; Sheffler DJ; De Backer LJS; Raveendra-Panickar D; Celeridad M; Grotegut S; Rodiles S; Holleran J; Sergienko E; Pasquale EB; Cosford NDP; Tautz L
J Biol Chem; 2020 Feb; 295(9):2601-2613. PubMed ID: 31953320
[TBL] [Abstract][Full Text] [Related]
14. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst.
Li XJ; Goodwin CB; Nabinger SC; Richine BM; Yang Z; Hanenberg H; Ohnishi H; Matozaki T; Feng GS; Chan RJ
J Biol Chem; 2015 Feb; 290(7):3894-909. PubMed ID: 25538234
[TBL] [Abstract][Full Text] [Related]
15.
Hill KS; Roberts ER; Wang X; Marin E; Park TD; Son S; Ren Y; Fang B; Yoder S; Kim S; Wan L; Sarnaik AA; Koomen JM; Messina JL; Teer JK; Kim Y; Wu J; Chalfant CE; Kim M
Mol Cancer Res; 2019 Feb; 17(2):583-593. PubMed ID: 30355677
[TBL] [Abstract][Full Text] [Related]
16. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Bard-Chapeau EA; Li S; Ding J; Zhang SS; Zhu HH; Princen F; Fang DD; Han T; Bailly-Maitre B; Poli V; Varki NM; Wang H; Feng GS
Cancer Cell; 2011 May; 19(5):629-39. PubMed ID: 21575863
[TBL] [Abstract][Full Text] [Related]
17. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.
LaRochelle JR; Fodor M; Vemulapalli V; Mohseni M; Wang P; Stams T; LaMarche MJ; Chopra R; Acker MG; Blacklow SC
Nat Commun; 2018 Oct; 9(1):4508. PubMed ID: 30375388
[TBL] [Abstract][Full Text] [Related]
18. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.
Li S; Hsu DD; Wang H; Feng GS
Front Med; 2012 Sep; 6(3):275-9. PubMed ID: 22869052
[TBL] [Abstract][Full Text] [Related]
19. Exploring the effect of E76K mutation on SHP2 cause gain-of-function activity by a molecular dynamics study.
Li WY; Wei HY; Sun YZ; Zhou H; Ma Y; Wang RL
J Cell Biochem; 2018 Dec; 119(12):9941-9956. PubMed ID: 30129165
[TBL] [Abstract][Full Text] [Related]
20. Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.
Lan L; Holland JD; Qi J; Grosskopf S; Rademann J; Vogel R; Györffy B; Wulf-Goldenberg A; Birchmeier W
EMBO J; 2015 Jun; 34(11):1493-508. PubMed ID: 25736378
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
