BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

226 related articles for article (PubMed ID: 23916688)

  • 1. Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast.
    Vredenburg G; Vassell KP; Commandeur JN; Vermeulen NP; Vos JC
    Toxicol Lett; 2013 Oct; 222(3):247-56. PubMed ID: 23916688
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.
    Dragovic S; Boerma JS; van Bergen L; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2010 Sep; 23(9):1467-76. PubMed ID: 20849150
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism related toxicity of diclofenac in yeast as model system.
    van Leeuwen JS; Vredenburg G; Dragovic S; Tjong TF; Vos JC; Vermeulen NP
    Toxicol Lett; 2011 Feb; 200(3):162-8. PubMed ID: 21111035
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
    Dragovic S; Boerma JS; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2013 Nov; 26(11):1632-41. PubMed ID: 24083800
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.
    Dragovic S; Venkataraman H; Begheijn S; Vermeulen NP; Commandeur JN
    Toxicol Lett; 2014 Jan; 224(2):272-81. PubMed ID: 24185126
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates.
    Rea V; Dragovic S; Boerma JS; de Kanter FJ; Vermeulen NP; Commandeur JN
    Drug Metab Dispos; 2011 Dec; 39(12):2411-20. PubMed ID: 21890734
    [TBL] [Abstract][Full Text] [Related]  

  • 7. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS; Vermeulen NP; Commandeur JN
    Chem Biol Interact; 2014 Jan; 207():32-40. PubMed ID: 24246759
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.
    Venkataraman H; den Braver MW; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2014 Dec; 27(12):2071-81. PubMed ID: 25372302
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.
    Damsten MC; de Vlieger JS; Niessen WM; Irth H; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2008 Nov; 21(11):2181-7. PubMed ID: 18816075
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
    Boerma JS; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2011 Aug; 24(8):1263-74. PubMed ID: 21639118
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of human cytochrome P450s involved in the bioactivation of clozapine.
    Dragovic S; Gunness P; Ingelman-Sundberg M; Vermeulen NP; Commandeur JN
    Drug Metab Dispos; 2013 Mar; 41(3):651-8. PubMed ID: 23297297
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.
    Boerma JS; Dragovic S; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2012 Nov; 25(11):2532-41. PubMed ID: 22998212
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites.
    Boerma JS; Elias NS; Vermeulen NP; Commandeur JN
    J Pharm Biomed Anal; 2015 Jan; 103():17-25. PubMed ID: 25462116
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.
    Vondracek M; Weaver DA; Sarang Z; Hedberg JJ; Willey JC; Wärngård L; Grafström RC
    Int J Cancer; 2002 Jun; 99(6):776-82. PubMed ID: 12115477
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Metabolism and bioactivation of clozapine by human liver in vitro.
    Pirmohamed M; Williams D; Madden S; Templeton E; Park BK
    J Pharmacol Exp Ther; 1995 Mar; 272(3):984-90. PubMed ID: 7891353
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.
    Damsten MC; van Vugt-Lussenburg BM; Zeldenthuis T; de Vlieger JS; Commandeur JN; Vermeulen NP
    Chem Biol Interact; 2008 Jan; 171(1):96-107. PubMed ID: 17996858
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria.
    Gallagher EP; Gardner JL; Barber DS
    Biochem Pharmacol; 2006 May; 71(11):1619-28. PubMed ID: 16616895
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives.
    Fujioka K; Casida JE
    Chem Res Toxicol; 2007 Aug; 20(8):1211-7. PubMed ID: 17645302
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Differences in the expression of xenobiotic-metabolizing enzymes between islets derived from the ventral and dorsal anlage of the pancreas.
    Standop J; Ulrich AB; Schneider MB; Büchler MW; Pour PM
    Pancreatology; 2002; 2(6):510-8. PubMed ID: 12435863
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.
    Abel EL; Lyon RP; Bammler TK; Verlinde CL; Lau SS; Monks TJ; Eaton DL
    Chem Biol Interact; 2004 Dec; 151(1):21-32. PubMed ID: 15607759
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.