These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
194 related articles for article (PubMed ID: 23954707)
21. Allosteric modulation of endogenous metabolites as an avenue for drug discovery. Wootten D; Savage EE; Valant C; May LT; Sloop KW; Ficorilli J; Showalter AD; Willard FS; Christopoulos A; Sexton PM Mol Pharmacol; 2012 Aug; 82(2):281-90. PubMed ID: 22576254 [TBL] [Abstract][Full Text] [Related]
22. Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance. Bosier B; Hermans E Trends Pharmacol Sci; 2007 Aug; 28(8):438-46. PubMed ID: 17629964 [TBL] [Abstract][Full Text] [Related]
23. Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events. Shaffer CL; Scialis RJ; Rong H; Obach RS Biopharm Drug Dispos; 2012 Mar; 33(2):72-84. PubMed ID: 22213407 [TBL] [Abstract][Full Text] [Related]
24. Inverse agonism: more than reverting constitutively active receptor signaling. Dupré DJ; Rola-Pleszczynski M; Stanková J Biochem Cell Biol; 2004 Dec; 82(6):676-80. PubMed ID: 15674435 [TBL] [Abstract][Full Text] [Related]
25. Endocrine receptors as targets for new drugs. Altman J Neuroendocrinology; 2006; 83(5-6):282-8. PubMed ID: 16926529 [TBL] [Abstract][Full Text] [Related]
26. Biased Receptor Signaling in Drug Discovery. Kenakin T Pharmacol Rev; 2019 Apr; 71(2):267-315. PubMed ID: 30914442 [TBL] [Abstract][Full Text] [Related]
27. Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities. Seifert R; Dove S Mol Pharmacol; 2009 Jan; 75(1):13-8. PubMed ID: 19001067 [TBL] [Abstract][Full Text] [Related]
28. Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity. Appleton KM; Lee MH; Alele C; Alele C; Luttrell DK; Peterson YK; Morinelli TA; Luttrell LM Methods Enzymol; 2013; 522():229-62. PubMed ID: 23374189 [TBL] [Abstract][Full Text] [Related]
29. G-protein-coupled receptor-focused drug discovery using a target class platform approach. Heilker R; Wolff M; Tautermann CS; Bieler M Drug Discov Today; 2009 Mar; 14(5-6):231-40. PubMed ID: 19121411 [TBL] [Abstract][Full Text] [Related]
30. The importance of chronobiology to drug discovery. Farrow SN; Solari R; Willson TM Expert Opin Drug Discov; 2012 Jul; 7(7):535-41. PubMed ID: 22657273 [TBL] [Abstract][Full Text] [Related]
31. Stereoselectivity of drug-receptor interactions. Soudjin W; van Wijngaarden I; IJzerman AP IDrugs; 2003 Jan; 6(1):43-56. PubMed ID: 12789621 [TBL] [Abstract][Full Text] [Related]
32. Network biology as a new approach to drug discovery. Lowe JA; Jones P; Wilson DM Curr Opin Drug Discov Devel; 2010 Sep; 13(5):524-6. PubMed ID: 20812143 [TBL] [Abstract][Full Text] [Related]
33. Regulator of G protein signaling proteins as drug targets: current state and future possibilities. Sjögren B Adv Pharmacol; 2011; 62():315-47. PubMed ID: 21907914 [TBL] [Abstract][Full Text] [Related]
34. What is pharmacological 'affinity'? Relevance to biased agonism and antagonism. Kenakin T Trends Pharmacol Sci; 2014 Sep; 35(9):434-41. PubMed ID: 25042457 [TBL] [Abstract][Full Text] [Related]
35. [G-protein-coupled receptors plasticity and signalling]. Galés C Med Sci (Paris); 2012 Oct; 28(10):883-5. PubMed ID: 23067421 [TBL] [Abstract][Full Text] [Related]
36. Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery. Pérot S; Sperandio O; Miteva MA; Camproux AC; Villoutreix BO Drug Discov Today; 2010 Aug; 15(15-16):656-67. PubMed ID: 20685398 [TBL] [Abstract][Full Text] [Related]