BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

150 related articles for article (PubMed ID: 23955100)

  • 1. Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance.
    Jamin Y; Eykyn TR; Poon E; Springer CJ; Robinson SP
    Mol Imaging Biol; 2014 Apr; 16(2):152-7. PubMed ID: 23955100
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using 19F magnetic resonance spectroscopy.
    Mancini L; Davies L; Friedlos F; Falck-Miniotis M; Dzik-Jurasz AS; Springer CJ; Leach MO; Payne GS
    NMR Biomed; 2009 Jun; 22(5):561-6. PubMed ID: 19259950
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Noninvasive detection of carboxypeptidase G2 activity in vivo.
    Jamin Y; Smyth L; Robinson SP; Poon ES; Eykyn TR; Springer CJ; Leach MO; Payne GS
    NMR Biomed; 2011 May; 24(4):343-50. PubMed ID: 20891022
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.
    Davies LC; Friedlos F; Hedley D; Martin J; Ogilvie LM; Scanlon IJ; Springer CJ
    J Med Chem; 2005 Aug; 48(16):5321-8. PubMed ID: 16078849
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
    Niculescu-Duvaz D; Niculescu-Duvaz I; Friedlos F; Martin J; Spooner R; Davies L; Marais R; Springer CJ
    J Med Chem; 1998 Dec; 41(26):5297-309. PubMed ID: 9857097
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
    Friedlos F; Lehouritis P; Ogilvie L; Hedley D; Davies L; Bermudes D; King I; Martin J; Marais R; Springer CJ
    Clin Cancer Res; 2008 Jul; 14(13):4259-66. PubMed ID: 18594008
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.
    Niculescu-Duvaz D; Niculescu-Duvaz I; Friedlos F; Martin J; Lehouritis P; Marais R; Springer CJ
    J Med Chem; 2003 Apr; 46(9):1690-705. PubMed ID: 12699387
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development of triazene prodrugs for ADEPT strategy: new insights into drug delivery system based on carboxypeptidase G2 activation.
    Capucha V; Mendes E; Francisco AP; Perry MJ
    Bioorg Med Chem Lett; 2012 Nov; 22(22):6903-8. PubMed ID: 23041157
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity.
    Jamin Y; Gabellieri C; Smyth L; Reynolds S; Robinson SP; Springer CJ; Leach MO; Payne GS; Eykyn TR
    Magn Reson Med; 2009 Nov; 62(5):1300-4. PubMed ID: 19780183
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
    Schepelmann S; Ogilvie LM; Hedley D; Friedlos F; Martin J; Scanlon I; Chen P; Marais R; Springer CJ
    Cancer Res; 2007 May; 67(10):4949-55. PubMed ID: 17510425
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug.
    Spooner RA; Martin J; Friedlos F; Marais R; Springer CJ
    Cancer Gene Ther; 2000 Oct; 7(10):1348-56. PubMed ID: 11059693
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Production of Long-Acting CNGRC-CPG2 Fusion Proteins: New Derivatives to Overcome Drug Immunogenicity of Ligand-Directed Enzyme Prodrug Therapy for Targeted Cancer Treatment.
    Al-Mansoori L; Al Qahtani AD; Elsinga P; Goda SK
    Technol Cancer Res Treat; 2021; 20():15330338211057371. PubMed ID: 34802309
    [No Abstract]   [Full Text] [Related]  

  • 13. Catalytic activity of an in vivo tumor targeted anti-CEA scFv::carboxypeptidase G2 fusion protein.
    Bhatia J; Sharma SK; Chester KA; Pedley RB; Boden RW; Read DA; Boxer GM; Michael NP; Begent RH
    Int J Cancer; 2000 Feb; 85(4):571-7. PubMed ID: 10699932
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.
    Niculescu-Duvaz I; Scanlon I; Niculescu-Duvaz D; Friedlos F; Martin J; Marais R; Springer CJ
    J Med Chem; 2004 May; 47(10):2651-8. PubMed ID: 15115406
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.
    Marais R; Spooner RA; Light Y; Martin J; Springer CJ
    Cancer Res; 1996 Oct; 56(20):4735-42. PubMed ID: 8840992
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2.
    Springer CJ; Antoniw P; Bagshawe KD; Searle F; Bisset GM; Jarman M
    J Med Chem; 1990 Feb; 33(2):677-81. PubMed ID: 2299634
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Simulation, phantom validation, and clinical evaluation of fast pH-weighted molecular imaging using amine chemical exchange saturation transfer echo planar imaging (CEST-EPI) in glioma at 3 T.
    Harris RJ; Cloughesy TF; Liau LM; Nghiemphu PL; Lai A; Pope WB; Ellingson BM
    NMR Biomed; 2016 Nov; 29(11):1563-1576. PubMed ID: 27717216
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy.
    Springer CJ; Niculescu-Duvaz I; Pedley RB
    J Med Chem; 1994 Jul; 37(15):2361-70. PubMed ID: 8057284
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site.
    Aldughaim MS; Alsaffar F; Barker MD
    Molecules; 2021 Jan; 26(3):. PubMed ID: 33504102
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biphasically Modulating the Activity of Carboxypeptidase G2 with Ultrasound.
    Ma W; Zhang Y; Zheng X; Yu T
    Cell Physiol Biochem; 2017; 42(4):1614-1622. PubMed ID: 28738357
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.