113 related articles for article (PubMed ID: 23981033)
1. Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.
Griffith DA; Dow RL; Huard K; Edmonds DJ; Bagley SW; Polivkova J; Zeng D; Garcia-Irizarry CN; Southers JA; Esler W; Amor P; Loomis K; McPherson K; Bahnck KB; Préville C; Banks T; Moore DE; Mathiowetz AM; Menhaji-Klotz E; Smith AC; Doran SD; Beebe DA; Dunn MF
J Med Chem; 2013 Sep; 56(17):7110-9. PubMed ID: 23981033
[TBL] [Abstract][Full Text] [Related]
2. Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors.
Huard K; Bagley SW; Menhaji-Klotz E; Préville C; Southers JA; Smith AC; Edmonds DJ; Lucas JC; Dunn MF; Allanson NM; Blaney EL; Garcia-Irizarry CN; Kohrt JT; Griffith DA; Dow RL
J Org Chem; 2012 Nov; 77(22):10050-7. PubMed ID: 23127254
[TBL] [Abstract][Full Text] [Related]
3. (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
Chonan T; Oi T; Yamamoto D; Yashiro M; Wakasugi D; Tanaka H; Ohoka-Sugita A; Io F; Koretsune H; Hiratate A
Bioorg Med Chem Lett; 2009 Dec; 19(23):6645-8. PubMed ID: 19853443
[TBL] [Abstract][Full Text] [Related]
4. Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.
Chonan T; Tanaka H; Yamamoto D; Yashiro M; Oi T; Wakasugi D; Ohoka-Sugita A; Io F; Koretsune H; Hiratate A
Bioorg Med Chem Lett; 2010 Jul; 20(13):3965-8. PubMed ID: 20537533
[TBL] [Abstract][Full Text] [Related]
5. Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.
Harada N; Oda Z; Hara Y; Fujinami K; Okawa M; Ohbuchi K; Yonemoto M; Ikeda Y; Ohwaki K; Aragane K; Tamai Y; Kusunoki J
Mol Cell Biol; 2007 Mar; 27(5):1881-8. PubMed ID: 17210641
[TBL] [Abstract][Full Text] [Related]
6. A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways.
Takagi H; Tanimoto K; Shimazaki A; Tonomura Y; Momosaki S; Sakamoto S; Abe K; Notoya M; Yukioka H
J Pharmacol Exp Ther; 2020 Mar; 372(3):256-263. PubMed ID: 31900320
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors.
Wei Q; Mei L; Yang Y; Ma H; Chen H; Zhang H; Zhou J
Bioorg Med Chem; 2018 Aug; 26(14):3866-3874. PubMed ID: 30049586
[TBL] [Abstract][Full Text] [Related]
8. Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Griffith DA; Kung DW; Esler WP; Amor PA; Bagley SW; Beysen C; Carvajal-Gonzalez S; Doran SD; Limberakis C; Mathiowetz AM; McPherson K; Price DA; Ravussin E; Sonnenberg GE; Southers JA; Sweet LJ; Turner SM; Vajdos FF
J Med Chem; 2014 Dec; 57(24):10512-26. PubMed ID: 25423286
[TBL] [Abstract][Full Text] [Related]
9. Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.
Schreurs M; van Dijk TH; Gerding A; Havinga R; Reijngoud DJ; Kuipers F
Diabetes Obes Metab; 2009 Oct; 11(10):987-91. PubMed ID: 19519866
[TBL] [Abstract][Full Text] [Related]
10. Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome.
Harwood HJ
Curr Opin Investig Drugs; 2004 Mar; 5(3):283-9. PubMed ID: 15083594
[TBL] [Abstract][Full Text] [Related]
11. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.
Cheng D; Chu CH; Chen L; Feder JN; Mintier GA; Wu Y; Cook JW; Harpel MR; Locke GA; An Y; Tamura JK
Protein Expr Purif; 2007 Jan; 51(1):11-21. PubMed ID: 16854592
[TBL] [Abstract][Full Text] [Related]
12. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Harriman G; Greenwood J; Bhat S; Huang X; Wang R; Paul D; Tong L; Saha AK; Westlin WF; Kapeller R; Harwood HJ
Proc Natl Acad Sci U S A; 2016 Mar; 113(13):E1796-805. PubMed ID: 26976583
[TBL] [Abstract][Full Text] [Related]
13. Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors.
Huang T; Sun J; Wang Q; Gao J; Liu Y
Molecules; 2015 Sep; 20(9):16221-34. PubMed ID: 26370948
[TBL] [Abstract][Full Text] [Related]
14. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bengtsson C; Blaho S; Saitton DB; Brickmann K; Broddefalk J; Davidsson O; Drmota T; Folmer R; Hallberg K; Hallén S; Hovland R; Isin E; Johannesson P; Kull B; Larsson LO; Löfgren L; Nilsson KE; Noeske T; Oakes N; Plowright AT; Schnecke V; Ståhlberg P; Sörme P; Wan H; Wellner E; Oster L
Bioorg Med Chem; 2011 May; 19(10):3039-53. PubMed ID: 21515056
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.
Jones JE; Esler WP; Patel R; Lanba A; Vera NB; Pfefferkorn JA; Vernochet C
PLoS One; 2017; 12(1):e0169566. PubMed ID: 28081256
[TBL] [Abstract][Full Text] [Related]
16. Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.
Kamata M; Yamashita T; Kina A; Tawada M; Endo S; Mizukami A; Sasaki M; Tani A; Nakano Y; Watanabe Y; Furuyama N; Funami M; Amano N; Fukatsu K
Bioorg Med Chem Lett; 2012 Jul; 22(14):4769-72. PubMed ID: 22677317
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
Gu YG; Weitzberg M; Clark RF; Xu X; Li Q; Zhang T; Hansen TM; Liu G; Xin Z; Wang X; Wang R; McNally T; Zinker BA; Frevert EU; Camp HS; Beutel BA; Sham HL
J Med Chem; 2006 Jun; 49(13):3770-3. PubMed ID: 16789734
[TBL] [Abstract][Full Text] [Related]
18. Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
Waring JF; Yang Y; Healan-Greenberg CH; Adler AL; Dickinson R; McNally T; Wang X; Weitzberg M; Xu X; Lisowski A; Warder SE; Gu YG; Zinker BA; Blomme EA; Camp HS
J Pharmacol Exp Ther; 2008 Feb; 324(2):507-16. PubMed ID: 18025247
[TBL] [Abstract][Full Text] [Related]
19. Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Kung DW; Griffith DA; Esler WP; Vajdos FF; Mathiowetz AM; Doran SD; Amor PA; Bagley SW; Banks T; Cabral S; Ford K; Garcia-Irizarry CN; Landis MS; Loomis K; McPherson K; Niosi M; Rockwell KL; Rose C; Smith AC; Southers JA; Tapley S; Tu M; Valentine JJ
Bioorg Med Chem Lett; 2015 Nov; 25(22):5352-6. PubMed ID: 26411795
[TBL] [Abstract][Full Text] [Related]
20. Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008.
Corbett JW
Expert Opin Ther Pat; 2009 Jul; 19(7):943-56. PubMed ID: 19552511
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
