222 related articles for article (PubMed ID: 23981180)
1. Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.
Mori T; Kikuchi E; Watanabe Y; Fujii S; Ishigami-Yuasa M; Kagechika H; Sohara E; Rai T; Sasaki S; Uchida S
Biochem J; 2013 Nov; 455(3):339-45. PubMed ID: 23981180
[TBL] [Abstract][Full Text] [Related]
2. Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II.
Zeniya M; Sohara E; Kita S; Iwamoto T; Susa K; Mori T; Oi K; Chiga M; Takahashi D; Yang SS; Lin SH; Rai T; Sasaki S; Uchida S
Hypertension; 2013 Nov; 62(5):872-8. PubMed ID: 24019400
[TBL] [Abstract][Full Text] [Related]
3. WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia.
Thomson MN; Cuevas CA; Bewarder TM; Dittmayer C; Miller LN; Si J; Cornelius RJ; Su XT; Yang CL; McCormick JA; Hadchouel J; Ellison DH; Bachmann S; Mutig K
Am J Physiol Renal Physiol; 2020 Jan; 318(1):F216-F228. PubMed ID: 31736353
[TBL] [Abstract][Full Text] [Related]
4. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.
Nishida H; Sohara E; Nomura N; Chiga M; Alessi DR; Rai T; Sasaki S; Uchida S
Hypertension; 2012 Oct; 60(4):981-90. PubMed ID: 22949526
[TBL] [Abstract][Full Text] [Related]
5. A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.
Ponce-Coria J; Markadieu N; Austin TM; Flammang L; Rios K; Welling PA; Delpire E
J Biol Chem; 2014 Jun; 289(25):17680-8. PubMed ID: 24811174
[TBL] [Abstract][Full Text] [Related]
6. Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.
Kikuchi E; Mori T; Zeniya M; Isobe K; Ishigami-Yuasa M; Fujii S; Kagechika H; Ishihara T; Mizushima T; Sasaki S; Sohara E; Rai T; Uchida S
J Am Soc Nephrol; 2015 Jul; 26(7):1525-36. PubMed ID: 25377078
[TBL] [Abstract][Full Text] [Related]
7. Development of WNK signaling inhibitors as a new class of antihypertensive drugs.
Ishigami-Yuasa M; Watanabe Y; Mori T; Masuno H; Fujii S; Kikuchi E; Uchida S; Kagechika H
Bioorg Med Chem; 2017 Jul; 25(14):3845-3852. PubMed ID: 28566208
[TBL] [Abstract][Full Text] [Related]
8. [WNK-SPAK-SLC12A signal cascade is a new therapeutic target for hypertension].
Kikuchi E; Mori T; Uchida S
Nihon Rinsho; 2015 Sep; 73(9):1597-605. PubMed ID: 26394527
[TBL] [Abstract][Full Text] [Related]
9. Cotransporters, WNKs and hypertension: an update.
Flatman PW
Curr Opin Nephrol Hypertens; 2008 Mar; 17(2):186-92. PubMed ID: 18277153
[TBL] [Abstract][Full Text] [Related]
10. NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice.
Bhuiyan MIH; Young CB; Jahan I; Hasan MN; Fischer S; Meor Azlan NF; Liu M; Chattopadhyay A; Huang H; Kahle KT; Zhang J; Poloyac SM; Molyneaux BJ; Straub AC; Deng X; Gomez D; Sun D
Stroke; 2022 May; 53(5):1720-1734. PubMed ID: 35272484
[TBL] [Abstract][Full Text] [Related]
11. Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling.
Fujii S; Kikuchi E; Watanabe Y; Suzuyama H; Ishigami-Yuasa M; Mori T; Isobe K; Uchida S; Kagechika H
Bioorg Med Chem Lett; 2020 Sep; 30(17):127408. PubMed ID: 32738993
[TBL] [Abstract][Full Text] [Related]
12. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
Chiga M; Rafiqi FH; Alessi DR; Sohara E; Ohta A; Rai T; Sasaki S; Uchida S
J Cell Sci; 2011 May; 124(Pt 9):1391-5. PubMed ID: 21486947
[TBL] [Abstract][Full Text] [Related]
13. WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension.
Brown A; Meor Azlan NF; Wu Z; Zhang J
Acta Pharmacol Sin; 2021 Apr; 42(4):508-517. PubMed ID: 32724175
[TBL] [Abstract][Full Text] [Related]
14. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.
Susa K; Kita S; Iwamoto T; Yang SS; Lin SH; Ohta A; Sohara E; Rai T; Sasaki S; Alessi DR; Uchida S
Clin Exp Nephrol; 2012 Aug; 16(4):530-8. PubMed ID: 22294159
[TBL] [Abstract][Full Text] [Related]
15. The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases.
AlAmri MA; Kadri H; Alderwick LJ; Jeeves M; Mehellou Y
Chembiochem; 2018 Oct; 19(19):2072-2080. PubMed ID: 29999233
[TBL] [Abstract][Full Text] [Related]
16. Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.
Sohara E; Uchida S
Nephrol Dial Transplant; 2016 Sep; 31(9):1417-24. PubMed ID: 26152401
[TBL] [Abstract][Full Text] [Related]
17. Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents.
Fujii S; Kikuchi E; Suzuyama H; Watanabe Y; Ishigami-Yuasa M; Masuno H; Mori T; Isobe K; Uchida S; Kagechika H
ChemMedChem; 2021 Sep; 16(18):2817-2822. PubMed ID: 34109743
[TBL] [Abstract][Full Text] [Related]
18. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.
Alessi DR; Zhang J; Khanna A; Hochdörfer T; Shang Y; Kahle KT
Sci Signal; 2014 Jul; 7(334):re3. PubMed ID: 25028718
[TBL] [Abstract][Full Text] [Related]
19. Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters.
Mercier-Zuber A; O'Shaughnessy KM
Curr Opin Nephrol Hypertens; 2011 Sep; 20(5):534-40. PubMed ID: 21610494
[TBL] [Abstract][Full Text] [Related]
20. NCC regulation by WNK signal cascade.
Uchida S; Mori T; Susa K; Sohara E
Front Physiol; 2022; 13():1081261. PubMed ID: 36685207
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]