198 related articles for article (PubMed ID: 23984327)
1. Metabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro-β-carboline by oxidative enzymes.
Herraiz T; Guillén H; Galisteo J
Biomed Res Int; 2013; 2013():248608. PubMed ID: 23984327
[TBL] [Abstract][Full Text] [Related]
2. N-methyltetrahydro-beta-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic beta-carbolinium cations by heme peroxidases.
Herraiz T; Guillén H; Galisteo J
Biochem Biophys Res Commun; 2007 Apr; 356(1):118-23. PubMed ID: 17346675
[TBL] [Abstract][Full Text] [Related]
3. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
Herraiz T; Guillén H; Arán VJ; Idle JR; Gonzalez FJ
Toxicol Appl Pharmacol; 2006 Nov; 216(3):387-98. PubMed ID: 16870220
[TBL] [Abstract][Full Text] [Related]
4. Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents.
Herraiz T
J Enzyme Inhib Med Chem; 2012 Dec; 27(6):810-7. PubMed ID: 21992679
[TBL] [Abstract][Full Text] [Related]
5. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).
Herraiz T; Arán VJ; Guillén H
Free Radic Res; 2009 Oct; 43(10):975-84. PubMed ID: 19669997
[TBL] [Abstract][Full Text] [Related]
6. Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).
Uehara S; Uno Y; Inoue T; Murayama N; Shimizu M; Sasaki E; Yamazaki H
Drug Metab Dispos; 2015 May; 43(5):735-42. PubMed ID: 25735838
[TBL] [Abstract][Full Text] [Related]
7. Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases.
Singer TP; Salach JI; Castagnoli N; Trevor A
Biochem J; 1986 May; 235(3):785-9. PubMed ID: 3489461
[TBL] [Abstract][Full Text] [Related]
8. Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+.
Wu E; Shinka T; Caldera-Munoz P; Yoshizumi H; Trevor A; Castagnoli N
Chem Res Toxicol; 1988; 1(3):186-94. PubMed ID: 2979730
[TBL] [Abstract][Full Text] [Related]
9. Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.
Herraiz T; Guillén H
Food Chem Toxicol; 2011 Aug; 49(8):1773-81. PubMed ID: 21554916
[TBL] [Abstract][Full Text] [Related]
10. Inactivation of monoamine oxidase by 3,3-dimethyl analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-dihydropyridinium ion. Dramatic effect of beta-mercaptoethanol on substrate turnover and enzyme inactivation.
Hiebert CK; Sayre LM; Silverman RB
J Biol Chem; 1989 Dec; 264(36):21516-21. PubMed ID: 2600079
[TBL] [Abstract][Full Text] [Related]
11. N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids.
Herraiz T
Food Chem Toxicol; 2016 Nov; 97():23-39. PubMed ID: 27523294
[TBL] [Abstract][Full Text] [Related]
12. 1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium.
Shi H; Noguchi N; Xu Y; Niki E
FEBS Lett; 1999 Nov; 461(3):196-200. PubMed ID: 10567696
[TBL] [Abstract][Full Text] [Related]
13. 1-Methyl-4-phenylpyridinium (MPP+) binds with high affinity to a beta-carboline binding site located on monoamine oxidase type A in rat brain.
May T
Neurosci Lett; 1993 Nov; 162(1-2):55-8. PubMed ID: 8121637
[TBL] [Abstract][Full Text] [Related]
14. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A.
Basma AN; Heikkila RE; Nicklas WJ; Giovanni A; Geller HM
J Neurochem; 1990 Sep; 55(3):870-7. PubMed ID: 2384758
[TBL] [Abstract][Full Text] [Related]
15. Involvement of hepatic aldehyde oxidase in conversion of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+) to 1-methyl-4-phenyl-5,6-dihydro-2-pyridone.
Yoshihara S; Ohta S
Arch Biochem Biophys; 1998 Dec; 360(1):93-8. PubMed ID: 9826433
[TBL] [Abstract][Full Text] [Related]
16. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Castagnoli N; Chiba K; Trevor AJ
Life Sci; 1985 Jan; 36(3):225-30. PubMed ID: 3871243
[TBL] [Abstract][Full Text] [Related]
17. Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Singer TP; Salach JI; Crabtree D
Biochem Biophys Res Commun; 1985 Mar; 127(2):707-12. PubMed ID: 3872126
[TBL] [Abstract][Full Text] [Related]
18. Characterization of novel dihydrothienopyridinium and thienopyridinium metabolites of ticlopidine in vitro: role of peroxidases, cytochromes p450, and monoamine oxidases.
Dalvie DK; O'Connell TN
Drug Metab Dispos; 2004 Jan; 32(1):49-57. PubMed ID: 14709620
[TBL] [Abstract][Full Text] [Related]
19. Mutagenicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its metabolites.
Cashman JR
Toxicology; 1987 Feb; 43(2):173-82. PubMed ID: 2949395
[TBL] [Abstract][Full Text] [Related]
20. Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.
Di Monte DA; Wu EY; Irwin I; Delanney LE; Langston JW
J Pharmacol Exp Ther; 1991 Aug; 258(2):594-600. PubMed ID: 1907660
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]