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2. Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop. Tanzer MC; Tripaydonis A; Webb AI; Young SN; Varghese LN; Hall C; Alexander WS; Hildebrand JM; Silke J; Murphy JM Biochem J; 2015 Oct; 471(2):255-65. PubMed ID: 26283547 [TBL] [Abstract][Full Text] [Related]
3. Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. Remijsen Q; Goossens V; Grootjans S; Van den Haute C; Vanlangenakker N; Dondelinger Y; Roelandt R; Bruggeman I; Goncalves A; Bertrand MJ; Baekelandt V; Takahashi N; Berghe TV; Vandenabeele P Cell Death Dis; 2014 Jan; 5(1):e1004. PubMed ID: 24434512 [TBL] [Abstract][Full Text] [Related]
4. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Rodriguez DA; Weinlich R; Brown S; Guy C; Fitzgerald P; Dillon CP; Oberst A; Quarato G; Low J; Cripps JG; Chen T; Green DR Cell Death Differ; 2016 Jan; 23(1):76-88. PubMed ID: 26024392 [TBL] [Abstract][Full Text] [Related]
5. RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury. Newton K; Dugger DL; Maltzman A; Greve JM; Hedehus M; Martin-McNulty B; Carano RA; Cao TC; van Bruggen N; Bernstein L; Lee WP; Wu X; DeVoss J; Zhang J; Jeet S; Peng I; McKenzie BS; Roose-Girma M; Caplazi P; Diehl L; Webster JD; Vucic D Cell Death Differ; 2016 Sep; 23(9):1565-76. PubMed ID: 27177019 [TBL] [Abstract][Full Text] [Related]
6. FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. Wang Z; Feng J; Yu J; Chen G J Cell Sci; 2019 May; 132(10):. PubMed ID: 31028177 [TBL] [Abstract][Full Text] [Related]
7. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Hildebrand JM; Tanzer MC; Lucet IS; Young SN; Spall SK; Sharma P; Pierotti C; Garnier JM; Dobson RC; Webb AI; Tripaydonis A; Babon JJ; Mulcair MD; Scanlon MJ; Alexander WS; Wilks AF; Czabotar PE; Lessene G; Murphy JM; Silke J Proc Natl Acad Sci U S A; 2014 Oct; 111(42):15072-7. PubMed ID: 25288762 [TBL] [Abstract][Full Text] [Related]
8. c-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and -independent activities. Cao M; Chen F; Xie N; Cao MY; Chen P; Lou Q; Zhao Y; He C; Zhang S; Song X; Sun Y; Zhu W; Mou L; Luan S; Gao H Cell Death Dis; 2018 Nov; 9(12):1140. PubMed ID: 30442927 [TBL] [Abstract][Full Text] [Related]
9. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Yoon S; Kovalenko A; Bogdanov K; Wallach D Immunity; 2017 Jul; 47(1):51-65.e7. PubMed ID: 28666573 [TBL] [Abstract][Full Text] [Related]
10. CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Zhan Q; Jeon J; Li Y; Huang Y; Xiong J; Wang Q; Xu TL; Li Y; Ji FH; Du G; Zhu MX Autophagy; 2022 Apr; 18(4):726-744. PubMed ID: 34282994 [TBL] [Abstract][Full Text] [Related]
12. A tale of two domains - a structural perspective of the pseudokinase, MLKL. Czabotar PE; Murphy JM FEBS J; 2015 Nov; 282(22):4268-78. PubMed ID: 26337687 [TBL] [Abstract][Full Text] [Related]
13. A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome. Yu X; Mao M; Liu X; Shen T; Li T; Yu H; Zhang J; Chen X; Zhao X; Zhu D J Mol Med (Berl); 2020 Apr; 98(4):569-583. PubMed ID: 32072232 [TBL] [Abstract][Full Text] [Related]
15. Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies. Petrie EJ; Birkinshaw RW; Koide A; Denbaum E; Hildebrand JM; Garnish SE; Davies KA; Sandow JJ; Samson AL; Gavin X; Fitzgibbon C; Young SN; Hennessy PJ; Smith PPC; Webb AI; Czabotar PE; Koide S; Murphy JM Proc Natl Acad Sci U S A; 2020 Apr; 117(15):8468-8475. PubMed ID: 32234780 [TBL] [Abstract][Full Text] [Related]
16. Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis. Garnish SE; Meng Y; Koide A; Sandow JJ; Denbaum E; Jacobsen AV; Yeung W; Samson AL; Horne CR; Fitzgibbon C; Young SN; Smith PPC; Webb AI; Petrie EJ; Hildebrand JM; Kannan N; Czabotar PE; Koide S; Murphy JM Nat Commun; 2021 Apr; 12(1):2211. PubMed ID: 33850121 [TBL] [Abstract][Full Text] [Related]
17. Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Yoon S; Bogdanov K; Kovalenko A; Wallach D Cell Death Differ; 2016 Feb; 23(2):253-60. PubMed ID: 26184911 [TBL] [Abstract][Full Text] [Related]
18. ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis. Ma B; Marcotte D; Paramasivam M; Michelsen K; Wang T; Bertolotti-Ciarlet A; Jones JH; Moree B; Butko M; Salafsky J; Sun X; McKee T; Silvian LF PLoS One; 2016; 11(11):e0165983. PubMed ID: 27832137 [TBL] [Abstract][Full Text] [Related]
19. Evolutionary divergence of the necroptosis effector MLKL. Tanzer MC; Matti I; Hildebrand JM; Young SN; Wardak A; Tripaydonis A; Petrie EJ; Mildenhall AL; Vaux DL; Vince JE; Czabotar PE; Silke J; Murphy JM Cell Death Differ; 2016 Jul; 23(7):1185-97. PubMed ID: 26868910 [TBL] [Abstract][Full Text] [Related]
20. MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis. Zhou T; DeRoo E; Yang H; Stranz A; Wang Q; Ginnan R; Singer HA; Liu B Cells; 2021 Sep; 10(9):. PubMed ID: 34572045 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]