BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

113 related articles for article (PubMed ID: 24018193)

  • 1. Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets.
    Saito A; Higgins M; Zheng S; Li W; Ojima I; Dinkova-Kostova AT; Honda T
    Bioorg Med Chem Lett; 2013 Oct; 23(20):5540-3. PubMed ID: 24018193
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.
    Honda T; Yoshizawa H; Sundararajan C; David E; Lajoie MJ; Favaloro FG; Janosik T; Su X; Honda Y; Roebuck BD; Gribble GW
    J Med Chem; 2011 Mar; 54(6):1762-78. PubMed ID: 21361338
    [TBL] [Abstract][Full Text] [Related]  

  • 3. (±)-(4bS,8aR,10aS)-10a-Ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octa-hydro-phenanthrene-2,6-dicarbonitrile.
    Zheng S; Resch D; Honda T; Jasinski JP
    Acta Crystallogr Sect E Struct Rep Online; 2012 Nov; 68(Pt 11):o3095-6. PubMed ID: 23284424
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1.
    Moreno R; Casares L; Higgins M; Ali KX; Honda T; Wiel C; Sayin VI; Dinkova-Kostova AT; de la Vega L
    Free Radic Biol Med; 2022 Oct; 191():203-211. PubMed ID: 36084789
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.
    Yao W; Zhang JC; Ishima T; Ren Q; Yang C; Dong C; Ma M; Saito A; Honda T; Hashimoto K
    Eur J Pharmacol; 2016 Dec; 793():21-27. PubMed ID: 27815170
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
    He X; Chen MG; Lin GX; Ma Q
    J Biol Chem; 2006 Aug; 281(33):23620-31. PubMed ID: 16785233
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.
    Ghorab MM; Higgins M; Alsaid MS; Arafa RK; Shahat AA; Dinkova-Kostova AT
    J Enzyme Inhib Med Chem; 2014 Dec; 29(6):840-5. PubMed ID: 24417210
    [TBL] [Abstract][Full Text] [Related]  

  • 8. New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
    Li W; Zheng S; Higgins M; Morra RP; Mendis AT; Chien CW; Ojima I; Mierke DF; Dinkova-Kostova AT; Honda T
    J Med Chem; 2015 Jun; 58(11):4738-48. PubMed ID: 25965897
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
    Reisman SA; Csanaky IL; Aleksunes LM; Klaassen CD
    Toxicol Sci; 2009 May; 109(1):31-40. PubMed ID: 19246624
    [TBL] [Abstract][Full Text] [Related]  

  • 10. NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.
    Vomhof-DeKrey EE; Picklo MJ
    Free Radic Biol Med; 2012 Aug; 53(4):690-700. PubMed ID: 22683604
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.
    He X; Ma Q
    J Pharmacol Exp Ther; 2010 Jan; 332(1):66-75. PubMed ID: 19808700
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.
    Luo L; Chen Y; Wu D; Shou J; Wang S; Ye J; Tang X; Wang XJ
    Toxicol Appl Pharmacol; 2015 Nov; 288(3):339-48. PubMed ID: 26291391
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
    Reisman SA; Yeager RL; Yamamoto M; Klaassen CD
    Toxicol Sci; 2009 Mar; 108(1):35-47. PubMed ID: 19129213
    [TBL] [Abstract][Full Text] [Related]  

  • 14. An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.
    Dinkova-Kostova AT; Talalay P; Sharkey J; Zhang Y; Holtzclaw WD; Wang XJ; David E; Schiavoni KH; Finlayson S; Mierke DF; Honda T
    J Biol Chem; 2010 Oct; 285(44):33747-55. PubMed ID: 20801881
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
    Kwon J; Han E; Bui CB; Shin W; Lee J; Lee S; Choi YB; Lee AH; Lee KH; Park C; Obin MS; Park SK; Seo YJ; Oh GT; Lee HW; Shin J
    EMBO Rep; 2012 Feb; 13(2):150-6. PubMed ID: 22222206
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.
    Copple IM; Goldring CE; Jenkins RE; Chia AJ; Randle LE; Hayes JD; Kitteringham NR; Park BK
    Hepatology; 2008 Oct; 48(4):1292-301. PubMed ID: 18785192
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance.
    Shi J; Zhang X; Jiang H
    Molecules; 2010 Aug; 15(8):5273-81. PubMed ID: 20714298
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1.
    Cheng Q; Taguchi K; Aleksunes LM; Manautou JE; Cherrington NJ; Yamamoto M; Slitt AL
    J Biochem Mol Toxicol; 2011; 25(5):320-9. PubMed ID: 21538727
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of NRF2 pathway in spleen, thymus as well as peripheral blood mononuclear cells by acute arsenic exposure in mice.
    Duan X; Li J; Zhang Y; Li W; Zhao L; Nie H; Sun G; Li B
    Int Immunopharmacol; 2015 Oct; 28(2):1059-67. PubMed ID: 26371860
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
    Yates MS; Tran QT; Dolan PM; Osburn WO; Shin S; McCulloch CC; Silkworth JB; Taguchi K; Yamamoto M; Williams CR; Liby KT; Sporn MB; Sutter TR; Kensler TW
    Carcinogenesis; 2009 Jun; 30(6):1024-31. PubMed ID: 19386581
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.