115 related articles for article (PubMed ID: 24041203)
1. Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries.
Cherny I; Greisen P; Ashani Y; Khare SD; Oberdorfer G; Leader H; Baker D; Tawfik DS
ACS Chem Biol; 2013 Nov; 8(11):2394-403. PubMed ID: 24041203
[TBL] [Abstract][Full Text] [Related]
2. Bioanalytical verification of V-type nerve agent exposure: simultaneous detection of phosphonylated tyrosines and cysteine-containing disulfide-adducts derived from human albumin.
Kranawetvogl A; Küppers J; Siegert M; Gütschow M; Worek F; Thiermann H; Elsinghorst PW; John H
Anal Bioanal Chem; 2018 Feb; 410(5):1463-1474. PubMed ID: 29322229
[TBL] [Abstract][Full Text] [Related]
3. Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents.
Briseño-Roa L; Hill J; Notman S; Sellers D; Smith AP; Timperley CM; Wetherell J; Williams NH; Williams GR; Fersht AR; Griffiths AD
J Med Chem; 2006 Jan; 49(1):246-55. PubMed ID: 16392809
[TBL] [Abstract][Full Text] [Related]
4. Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
Wille T; Tenberken O; Reiter G; Müller S; Le Provost R; Lafont O; Estour F; Thiermann H; Worek F
Toxicology; 2009 Nov; 265(3):96-100. PubMed ID: 19800384
[TBL] [Abstract][Full Text] [Related]
5. Post-VX exposure treatment of rats with engineered phosphotriesterases.
Stigler L; Köhler A; Koller M; Job L; Escher B; Potschka H; Thiermann H; Skerra A; Worek F; Wille T
Arch Toxicol; 2022 Feb; 96(2):571-583. PubMed ID: 34962578
[TBL] [Abstract][Full Text] [Related]
6. Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study.
Worek F; Seeger T; Reiter G; Goldsmith M; Ashani Y; Leader H; Sussman JL; Aggarwal N; Thiermann H; Tawfik DS
Toxicol Lett; 2014 Nov; 231(1):45-54. PubMed ID: 25195526
[TBL] [Abstract][Full Text] [Related]
7. Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.
Goldsmith M; Eckstein S; Ashani Y; Greisen P; Leader H; Sussman JL; Aggarwal N; Ovchinnikov S; Tawfik DS; Baker D; Thiermann H; Worek F
Arch Toxicol; 2016 Nov; 90(11):2711-2724. PubMed ID: 26612364
[TBL] [Abstract][Full Text] [Related]
8. Overcoming the Challenges of Enzyme Evolution To Adapt Phosphotriesterase for V-Agent Decontamination.
Bigley AN; Desormeaux E; Xiang DF; Bae SY; Harvey SP; Raushel FM
Biochemistry; 2019 Apr; 58(15):2039-2053. PubMed ID: 30893549
[TBL] [Abstract][Full Text] [Related]
9. Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.
Ghanem E; Li Y; Xu C; Raushel FM
Biochemistry; 2007 Aug; 46(31):9032-40. PubMed ID: 17630782
[TBL] [Abstract][Full Text] [Related]
10. Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.
Goldsmith M; Aggarwal N; Ashani Y; Jubran H; Greisen PJ; Ovchinnikov S; Leader H; Baker D; Sussman JL; Goldenzweig A; Fleishman SJ; Tawfik DS
Protein Eng Des Sel; 2017 Apr; 30(4):333-345. PubMed ID: 28159998
[TBL] [Abstract][Full Text] [Related]
11. Enzymatic hydrolysis of Russian-VX by organophosphorus hydrolase.
Rastogi VK; DeFrank JJ; Cheng TC; Wild JR
Biochem Biophys Res Commun; 1997 Dec; 241(2):294-6. PubMed ID: 9425265
[TBL] [Abstract][Full Text] [Related]
12. Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR.
Bigley AN; Mabanglo MF; Harvey SP; Raushel FM
Biochemistry; 2015 Sep; 54(35):5502-12. PubMed ID: 26274608
[TBL] [Abstract][Full Text] [Related]
13. Enzymatic neutralization of the chemical warfare agent VX: evolution of phosphotriesterase for phosphorothiolate hydrolysis.
Bigley AN; Xu C; Henderson TJ; Harvey SP; Raushel FM
J Am Chem Soc; 2013 Jul; 135(28):10426-32. PubMed ID: 23789980
[TBL] [Abstract][Full Text] [Related]
14. New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.
Kalakuntla RK; Wille T; Le Provost R; Letort S; Reiter G; Müller S; Thiermann H; Worek F; Gouhier G; Lafont O; Estour F
Toxicol Lett; 2013 Feb; 216(2-3):200-5. PubMed ID: 23201439
[TBL] [Abstract][Full Text] [Related]
15. Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
Kirby SD; Norris JR; Richard Smith J; Bahnson BJ; Cerasoli DM
Chem Biol Interact; 2013 Mar; 203(1):181-5. PubMed ID: 23159884
[TBL] [Abstract][Full Text] [Related]
16. Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis.
Costante M; Biggemann L; Alamneh Y; Soojhawon I; Short R; Nigam S; Garcia G; Doctor BP; Valiyaveettil M; Nambiar MP
Toxicol In Vitro; 2012 Feb; 26(1):182-8. PubMed ID: 22120822
[TBL] [Abstract][Full Text] [Related]
17. Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.
Ordentlich A; Barak D; Sod-Moriah G; Kaplan D; Mizrahi D; Segall Y; Kronman C; Karton Y; Lazar A; Marcus D; Velan B; Shafferman A
Biochemistry; 2004 Sep; 43(35):11255-65. PubMed ID: 15366935
[TBL] [Abstract][Full Text] [Related]
18. Comparison of the hydrolytic stability of S-(N,N-diethylaminoethyl) isobutyl methylphosphonothiolate with VX in dilute solution.
Crenshaw MD; Hayes TL; Miller TL; Shannon CM
J Appl Toxicol; 2001 Dec; 21 Suppl 1():S3-6. PubMed ID: 11920912
[TBL] [Abstract][Full Text] [Related]
19. Rational design of organophosphorus hydrolase with high catalytic efficiency for detoxifying a V-type nerve agent.
Jeong YS; Choi JM; Kyeong HH; Choi JY; Kim EJ; Kim HS
Biochem Biophys Res Commun; 2014 Jul; 449(3):263-7. PubMed ID: 24824182
[TBL] [Abstract][Full Text] [Related]
20. The prediction of acute toxicity (LD
Noga M; Michalska A; Jurowski K
Arch Toxicol; 2024 Jan; 98(1):267-275. PubMed ID: 38051368
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
