BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 24077964)

  • 1. Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice.
    Lapinski PE; Meyer MF; Feng GS; Kamiya N; King PD
    Dis Model Mech; 2013 Nov; 6(6):1448-58. PubMed ID: 24077964
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.
    Bauler TJ; Kamiya N; Lapinski PE; Langewisch E; Mishina Y; Wilkinson JE; Feng GS; King PD
    Dis Model Mech; 2011 Mar; 4(2):228-39. PubMed ID: 21068439
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase.
    Kamiya N; Kim HK; King PD
    Bone; 2014 Dec; 69():55-60. PubMed ID: 25178522
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
    Yang W; Wang J; Moore DC; Liang H; Dooner M; Wu Q; Terek R; Chen Q; Ehrlich MG; Quesenberry PJ; Neel BG
    Nature; 2013 Jul; 499(7459):491-5. PubMed ID: 23863940
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
    Wang S; Yu WM; Zhang W; McCrae KR; Neel BG; Qu CK
    J Biol Chem; 2009 Jan; 284(2):913-20. PubMed ID: 19008228
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation.
    Eminaga S; Bennett AM
    J Biol Chem; 2008 May; 283(22):15328-38. PubMed ID: 18378677
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
    Xu D; Wang S; Yu WM; Chan G; Araki T; Bunting KD; Neel BG; Qu CK
    Blood; 2010 Nov; 116(18):3611-21. PubMed ID: 20651068
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice.
    Coulombe G; Leblanc C; Cagnol S; Maloum F; Lemieux E; Perreault N; Feng GS; Boudreau F; Rivard N
    Mol Cell Biol; 2013 Jun; 33(11):2275-84. PubMed ID: 23530062
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.
    Dong L; Yu WM; Zheng H; Loh ML; Bunting ST; Pauly M; Huang G; Zhou M; Broxmeyer HE; Scadden DT; Qu CK
    Nature; 2016 Nov; 539(7628):304-308. PubMed ID: 27783593
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.
    Miyamoto D; Miyamoto M; Takahashi A; Yomogita Y; Higashi H; Kondo S; Hatakeyama M
    Oncogene; 2008 Jun; 27(25):3508-15. PubMed ID: 18223690
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The use of SHP-2 gene transduced bone marrow mesenchymal stem cells to promote osteogenic differentiation and bone defect repair in rat.
    Fan D; Liu S; Jiang S; Li Z; Mo X; Ruan H; Zou GM; Fan C
    J Biomed Mater Res A; 2016 Aug; 104(8):1871-81. PubMed ID: 26999642
    [TBL] [Abstract][Full Text] [Related]  

  • 12. SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
    Langdon Y; Tandon P; Paden E; Duddy J; Taylor JM; Conlon FL
    Development; 2012 Mar; 139(5):948-57. PubMed ID: 22278918
    [TBL] [Abstract][Full Text] [Related]  

  • 13. SHP-2 regulates growth factor dependent vascular signalling and function.
    Mannell H; Krotz F
    Mini Rev Med Chem; 2014; 14(6):471-83. PubMed ID: 22512561
    [TBL] [Abstract][Full Text] [Related]  

  • 14. SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.
    Bowen ME; Ayturk UM; Kurek KC; Yang W; Warman ML
    PLoS Genet; 2014; 10(5):e1004364. PubMed ID: 24875294
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis.
    Loh ML; Vattikuti S; Schubbert S; Reynolds MG; Carlson E; Lieuw KH; Cheng JW; Lee CM; Stokoe D; Bonifas JM; Curtiss NP; Gotlib J; Meshinchi S; Le Beau MM; Emanuel PD; Shannon KM
    Blood; 2004 Mar; 103(6):2325-31. PubMed ID: 14644997
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.
    Qu CK; Yu WM; Azzarelli B; Feng GS
    Proc Natl Acad Sci U S A; 1999 Jul; 96(15):8528-33. PubMed ID: 10411909
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
    Deng Z; Ma S; Zhou H; Zang A; Fang Y; Li T; Shi H; Liu M; Du M; Taylor PR; Zhu HH; Chen J; Meng G; Li F; Chen C; Zhang Y; Jia XM; Lin X; Zhang X; Pearlman E; Li X; Feng GS; Xiao H
    Nat Immunol; 2015 Jun; 16(6):642-52. PubMed ID: 25915733
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
    Gagné-Sansfacon J; Langlois A; Langlois MJ; Coulombe G; Tremblay S; Vaillancourt-Lavigueur V; Qu CK; Menendez A; Rivard N
    J Pathol; 2019 Jan; 247(1):135-146. PubMed ID: 30376595
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation.
    Fragale A; Tartaglia M; Wu J; Gelb BD
    Hum Mutat; 2004 Mar; 23(3):267-77. PubMed ID: 14974085
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.
    Uhlén P; Burch PM; Zito CI; Estrada M; Ehrlich BE; Bennett AM
    Proc Natl Acad Sci U S A; 2006 Feb; 103(7):2160-5. PubMed ID: 16461457
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.