659 related articles for article (PubMed ID: 24078628)
1. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage.
Wunderlich P; Glebov K; Kemmerling N; Tien NT; Neumann H; Walter J
J Biol Chem; 2013 Nov; 288(46):33027-36. PubMed ID: 24078628
[TBL] [Abstract][Full Text] [Related]
2. γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.
Steiner A; Schlepckow K; Brunner B; Steiner H; Haass C; Hagn F
EMBO J; 2020 Oct; 39(20):e104247. PubMed ID: 32830336
[TBL] [Abstract][Full Text] [Related]
3. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.
Zhong L; Chen XF; Zhang ZL; Wang Z; Shi XZ; Xu K; Zhang YW; Xu H; Bu G
J Biol Chem; 2015 Jun; 290(25):15866-15877. PubMed ID: 25957402
[TBL] [Abstract][Full Text] [Related]
4. Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).
Glebov K; Wunderlich P; Karaca I; Walter J
J Neuroinflammation; 2016 Jan; 13():17. PubMed ID: 26792193
[TBL] [Abstract][Full Text] [Related]
5. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
Schlepckow K; Kleinberger G; Fukumori A; Feederle R; Lichtenthaler SF; Steiner H; Haass C
EMBO Mol Med; 2017 Oct; 9(10):1356-1365. PubMed ID: 28855300
[TBL] [Abstract][Full Text] [Related]
6. Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication.
Wei Y; Ma M; Lin S; Li X; Shu Y; Wang Z; Zhou Y; Hu B; Cheng B; Duan S; Huang X; Xu H; Zhang YW; Zheng H
J Cell Mol Med; 2021 May; 25(9):4516-4521. PubMed ID: 33783963
[TBL] [Abstract][Full Text] [Related]
7. TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Thornton P; Sevalle J; Deery MJ; Fraser G; Zhou Y; Ståhl S; Franssen EH; Dodd RB; Qamar S; Gomez Perez-Nievas B; Nicol LS; Eketjäll S; Revell J; Jones C; Billinton A; St George-Hyslop PH; Chessell I; Crowther DC
EMBO Mol Med; 2017 Oct; 9(10):1366-1378. PubMed ID: 28855301
[TBL] [Abstract][Full Text] [Related]
8. Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2.
Haure-Mirande JV; Audrain M; Ehrlich ME; Gandy S
Mol Neurodegener; 2022 Aug; 17(1):55. PubMed ID: 36002854
[TBL] [Abstract][Full Text] [Related]
9. Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia.
Sessa G; Podini P; Mariani M; Meroni A; Spreafico R; Sinigaglia F; Colonna M; Panina P; Meldolesi J
Eur J Neurosci; 2004 Nov; 20(10):2617-28. PubMed ID: 15548205
[TBL] [Abstract][Full Text] [Related]
10. A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region.
Ibach M; Mathews M; Linnartz-Gerlach B; Theil S; Kumar S; Feederle R; Brüstle O; Neumann H; Walter J
Glia; 2021 May; 69(5):1126-1139. PubMed ID: 33314333
[TBL] [Abstract][Full Text] [Related]
11. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
Varnum MM; Clayton KA; Yoshii-Kitahara A; Yonemoto G; Koro L; Ikezu S; Ikezu T
J Biol Chem; 2017 Jun; 292(25):10651-10663. PubMed ID: 28490631
[TBL] [Abstract][Full Text] [Related]
12. Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
Lichtenthaler SF; Tschirner SK; Steiner H
Curr Opin Neurobiol; 2022 Feb; 72():101-110. PubMed ID: 34689040
[TBL] [Abstract][Full Text] [Related]
13. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.
Kuhn PH; Marjaux E; Imhof A; De Strooper B; Haass C; Lichtenthaler SF
J Biol Chem; 2007 Apr; 282(16):11982-95. PubMed ID: 17307738
[TBL] [Abstract][Full Text] [Related]
14. Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Audrain M; Haure-Mirande JV; Mleczko J; Wang M; Griffin JK; St George-Hyslop PH; Fraser P; Zhang B; Gandy S; Ehrlich ME
Alzheimers Dement; 2021 Feb; 17(2):149-163. PubMed ID: 33314529
[TBL] [Abstract][Full Text] [Related]
15. Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
Zhang L; Bukulin M; Kojro E; Roth A; Metz VV; Fahrenholz F; Nawroth PP; Bierhaus A; Postina R
J Biol Chem; 2008 Dec; 283(51):35507-16. PubMed ID: 18952609
[TBL] [Abstract][Full Text] [Related]
16. The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP).
Houri N; Huang KC; Nalbantoglu J
PLoS One; 2013; 8(8):e73296. PubMed ID: 24015300
[TBL] [Abstract][Full Text] [Related]
17. Intracellular trafficking of TREM2 is regulated by presenilin 1.
Zhao Y; Li X; Huang T; Jiang LL; Tan Z; Zhang M; Cheng IH; Wang X; Bu G; Zhang YW; Wang Q; Xu H
Exp Mol Med; 2017 Dec; 49(12):e405. PubMed ID: 29611543
[TBL] [Abstract][Full Text] [Related]
18. Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging.
Konishi H; Kiyama H
Neurochem Int; 2020 Dec; 141():104878. PubMed ID: 33049336
[TBL] [Abstract][Full Text] [Related]
19. ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.
Feuerbach D; Schindler P; Barske C; Joller S; Beng-Louka E; Worringer KA; Kommineni S; Kaykas A; Ho DJ; Ye C; Welzenbach K; Elain G; Klein L; Brzak I; Mir AK; Farady CJ; Aichholz R; Popp S; George N; Neumann U
Neurosci Lett; 2017 Nov; 660():109-114. PubMed ID: 28923481
[TBL] [Abstract][Full Text] [Related]
20. Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models.
Martiskainen H; Viswanathan J; Nykänen NP; Kurki M; Helisalmi S; Natunen T; Sarajärvi T; Kurkinen KM; Pursiheimo JP; Rauramaa T; Alafuzoff I; Jääskeläinen JE; Leinonen V; Soininen H; Haapasalo A; Huttunen HJ; Hiltunen M
Neurobiol Aging; 2015 Feb; 36(2):1221.e15-28. PubMed ID: 25281018
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
