BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

169 related articles for article (PubMed ID: 24097670)

  • 1. Hepatic clearance of 6 polycyclic aromatic hydrocarbons by isolated perfused trout livers: prediction from in vitro clearance by liver S9 fractions.
    Nichols JW; Hoffman AD; ter Laak TL; Fitzsimmons PN
    Toxicol Sci; 2013 Dec; 136(2):359-72. PubMed ID: 24097670
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish.
    Fay KA; Fitzsimmons PN; Hoffman AD; Nichols JW
    Environ Toxicol Chem; 2017 Feb; 36(2):463-471. PubMed ID: 27487575
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals.
    Escher BI; Cowan-Ellsberry CE; Dyer S; Embry MR; Erhardt S; Halder M; Kwon JH; Johanning K; Oosterwijk MT; Rutishauser S; Segner H; Nichols J
    Chem Res Toxicol; 2011 Jul; 24(7):1134-43. PubMed ID: 21604782
    [TBL] [Abstract][Full Text] [Related]  

  • 4. In vitro-in vivo extrapolation of hepatic and gastrointestinal biotransformation rates of hydrophobic chemicals in rainbow trout.
    Saunders LJ; Fitzsimmons PN; Nichols JW; Gobas FAPC
    Aquat Toxicol; 2020 Nov; 228():105629. PubMed ID: 33002683
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biotransformation of Polycyclic Aromatic Hydrocarbons by Trout Liver S9 Fractions: Evaluation of Competitive Inhibition Using a Substrate Depletion Approach.
    Nichols JW; Ladd MA; Hoffman AD; Fitzsimmons PN
    Environ Toxicol Chem; 2019 Dec; 38(12):2729-2739. PubMed ID: 31505707
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin.
    Nichols JW; Hoffman AD; Fitzsimmons PN
    Aquat Toxicol; 2009 Nov; 95(3):182-94. PubMed ID: 19837470
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial.
    Nichols J; Fay K; Bernhard MJ; Bischof I; Davis J; Halder M; Hu J; Johanning K; Laue H; Nabb D; Schlechtriem C; Segner H; Swintek J; Weeks J; Embry M
    Toxicol Sci; 2018 Aug; 164(2):563-575. PubMed ID: 29767801
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro biotransformation rates in fish liver S9: effect of dosing techniques.
    Lee YS; Lee DH; Delafoulhouze M; Otton SV; Moore MM; Kennedy CJ; Gobas FA
    Environ Toxicol Chem; 2014 Aug; 33(8):1885-93. PubMed ID: 24832019
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Toward improved models for predicting bioconcentration of well-metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance.
    Nichols JW; Huggett DB; Arnot JA; Fitzsimmons PN; Cowan-Ellsberry CE
    Environ Toxicol Chem; 2013 Jul; 32(7):1611-22. PubMed ID: 23504707
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Predicting the bioconcentration of fragrance ingredients by rainbow trout using measured rates of in vitro intrinsic clearance.
    Laue H; Gfeller H; Jenner KJ; Nichols JW; Kern S; Natsch A
    Environ Sci Technol; 2014 Aug; 48(16):9486-95. PubMed ID: 25058173
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In Vitro-In Vivo Extrapolation of Hepatic Biotransformation Data for Fish. III. An In-depth Case Study with Pyrene.
    Nichols JW; Fitzsimmons PN; Hoffman AD; Wong K
    Environ Toxicol Chem; 2023 Jul; 42(7):1501-1515. PubMed ID: 37014178
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Concentration dependence of biotransformation in fish liver S9: Optimizing substrate concentrations to estimate hepatic clearance for bioaccumulation assessment.
    Lo JC; Allard GN; Otton SV; Campbell DA; Gobas FA
    Environ Toxicol Chem; 2015 Dec; 34(12):2782-90. PubMed ID: 26077187
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Liver microsomes and S9 from rainbow trout (Oncorhynchus mykiss): comparison of basal-level enzyme activities with rat and determination of xenobiotic intrinsic clearance in support of bioaccumulation assessment.
    Han X; Nabb DL; Yang CH; Snajdr SI; Mingoia RT
    Environ Toxicol Chem; 2009 Mar; 28(3):481-8. PubMed ID: 18937539
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment.
    Han X; Nabb DL; Mingoia RT; Yang CH
    Environ Sci Technol; 2007 May; 41(9):3269-76. PubMed ID: 17539536
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Allometric scaling of hepatic biotransformation in rainbow trout.
    Fitzsimmons PN; Hoffman AD; Fay KA; Nichols JW
    Comp Biochem Physiol C Toxicol Pharmacol; 2018 Dec; 214():52-60. PubMed ID: 30172734
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations.
    Han X; Mingoia RT; Nabb DL; Yang CH; Snajdr SI; Hoke RA
    Aquat Toxicol; 2008 Aug; 89(1):11-7. PubMed ID: 18599132
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Validation of Methods for
    Schultz M; Krause S; Brinkmann M
    Environ Sci Technol; 2022 Sep; 56(17):12416-12423. PubMed ID: 35994365
    [No Abstract]   [Full Text] [Related]  

  • 18. In Vitro Biotransformation Assays Using Liver S9 Fractions and Hepatocytes from Rainbow Trout (Oncorhynchus mykiss): Overcoming Challenges with Difficult to Test Fragrance Chemicals.
    Kropf C; Begnaud F; Gimeno S; Berthaud F; Debonneville C; Segner H
    Environ Toxicol Chem; 2020 Dec; 39(12):2396-2408. PubMed ID: 32915480
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Measurement of kinetic parameters for biotransformation of polycyclic aromatic hydrocarbons by trout liver S9 fractions: Implications for bioaccumulation assessment.
    Nichols JW; Ladd MA; Fitzsimmons PN
    Appl In Vitro Toxicol; 2018; 4(4):365-378. PubMed ID: 31179352
    [No Abstract]   [Full Text] [Related]  

  • 20. Tissue-specific metabolism of benzo[a]pyrene in rainbow trout (Oncorhynchus mykiss): a comparison between the liver and immune organs.
    Möller AM; Hermsen C; Floehr T; Lamoree MH; Segner H
    Drug Metab Dispos; 2014 Jan; 42(1):111-8. PubMed ID: 24144719
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.