412 related articles for article (PubMed ID: 24099007)
1. Toward the structure of presenilin/γ-secretase and presenilin homologs.
Wolfe MS
Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
[TBL] [Abstract][Full Text] [Related]
2. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.
Zhou R; Yang G; Shi Y
Proc Natl Acad Sci U S A; 2017 Nov; 114(48):12731-12736. PubMed ID: 29078389
[TBL] [Abstract][Full Text] [Related]
3. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
[TBL] [Abstract][Full Text] [Related]
4. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
Feilen LP; Chen SY; Fukumori A; Feederle R; Zacharias M; Steiner H
Elife; 2022 May; 11():. PubMed ID: 35579427
[TBL] [Abstract][Full Text] [Related]
5. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
Steiner H; Winkler E; Haass C
J Biol Chem; 2008 Dec; 283(50):34677-86. PubMed ID: 18801744
[TBL] [Abstract][Full Text] [Related]
6. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
7. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
[TBL] [Abstract][Full Text] [Related]
8. Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.
Chiang PM; Fortna RR; Price DL; Li T; Wong PC
Neurobiol Aging; 2012 Feb; 33(2):277-85. PubMed ID: 20382452
[TBL] [Abstract][Full Text] [Related]
9. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
10. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
Kim M; Bezprozvanny I
Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
[TBL] [Abstract][Full Text] [Related]
11. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
[TBL] [Abstract][Full Text] [Related]
12. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.
Zhang X; Sullivan E; Scimeca M; Wu X; Li YM; Sisodia SS
J Biol Chem; 2016 Mar; 291(13):6748-53. PubMed ID: 26887941
[TBL] [Abstract][Full Text] [Related]
13. Assembly of the presenilin γ-/ε-secretase complex.
St George-Hyslop P; Fraser PE
J Neurochem; 2012 Jan; 120 Suppl 1():84-88. PubMed ID: 22122073
[TBL] [Abstract][Full Text] [Related]
14. Structural basis of human γ-secretase assembly.
Sun L; Zhao L; Yang G; Yan C; Zhou R; Zhou X; Xie T; Zhao Y; Wu S; Li X; Shi Y
Proc Natl Acad Sci U S A; 2015 May; 112(19):6003-8. PubMed ID: 25918421
[TBL] [Abstract][Full Text] [Related]
15. Gamma-secretase--intramembrane protease with a complex.
Wolfe MS
Sci Aging Knowledge Environ; 2003 Mar; 2003(11):PE7. PubMed ID: 12844518
[TBL] [Abstract][Full Text] [Related]
16. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
[TBL] [Abstract][Full Text] [Related]
17. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Wang J; Beher D; Nyborg AC; Shearman MS; Golde TE; Goate A
J Neurochem; 2006 Jan; 96(1):218-27. PubMed ID: 16305624
[TBL] [Abstract][Full Text] [Related]
18. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Wolfe MS; De Los Angeles J; Miller DD; Xia W; Selkoe DJ
Biochemistry; 1999 Aug; 38(35):11223-30. PubMed ID: 10471271
[TBL] [Abstract][Full Text] [Related]
19. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
20. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
Fukumori A; Fluhrer R; Steiner H; Haass C
J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]