BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

412 related articles for article (PubMed ID: 24099007)

  • 1. Toward the structure of presenilin/γ-secretase and presenilin homologs.
    Wolfe MS
    Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.
    Zhou R; Yang G; Shi Y
    Proc Natl Acad Sci U S A; 2017 Nov; 114(48):12731-12736. PubMed ID: 29078389
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
    Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
    Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
    Feilen LP; Chen SY; Fukumori A; Feederle R; Zacharias M; Steiner H
    Elife; 2022 May; 11():. PubMed ID: 35579427
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
    Steiner H; Winkler E; Haass C
    J Biol Chem; 2008 Dec; 283(50):34677-86. PubMed ID: 18801744
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
    Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
    J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
    Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
    J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.
    Chiang PM; Fortna RR; Price DL; Li T; Wong PC
    Neurobiol Aging; 2012 Feb; 33(2):277-85. PubMed ID: 20382452
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
    Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
    Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.
    Zhang X; Sullivan E; Scimeca M; Wu X; Li YM; Sisodia SS
    J Biol Chem; 2016 Mar; 291(13):6748-53. PubMed ID: 26887941
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Assembly of the presenilin γ-/ε-secretase complex.
    St George-Hyslop P; Fraser PE
    J Neurochem; 2012 Jan; 120 Suppl 1():84-88. PubMed ID: 22122073
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural basis of human γ-secretase assembly.
    Sun L; Zhao L; Yang G; Yan C; Zhou R; Zhou X; Xie T; Zhao Y; Wu S; Li X; Shi Y
    Proc Natl Acad Sci U S A; 2015 May; 112(19):6003-8. PubMed ID: 25918421
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Gamma-secretase--intramembrane protease with a complex.
    Wolfe MS
    Sci Aging Knowledge Environ; 2003 Mar; 2003(11):PE7. PubMed ID: 12844518
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 17. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
    Wang J; Beher D; Nyborg AC; Shearman MS; Golde TE; Goate A
    J Neurochem; 2006 Jan; 96(1):218-27. PubMed ID: 16305624
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
    Wolfe MS; De Los Angeles J; Miller DD; Xia W; Selkoe DJ
    Biochemistry; 1999 Aug; 38(35):11223-30. PubMed ID: 10471271
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
    Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
    Fukumori A; Fluhrer R; Steiner H; Haass C
    J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.