351 related articles for article (PubMed ID: 24113238)
1. Design and synthesis of novel 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines as small molecule BACE-1 inhibitors.
Razzaghi-Asl N; Firuzi O; Hemmateenejad B; Javidnia K; Edraki N; Miri R
Bioorg Med Chem; 2013 Nov; 21(22):6893-909. PubMed ID: 24113238
[TBL] [Abstract][Full Text] [Related]
2. Inhibitors of Alzheimer's BACE-1 with 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridine structure.
Miri R; Firuzi O; Razzaghi-Asl N; Javidnia K; Edraki N
Arch Pharm Res; 2015 Apr; 38(4):456-69. PubMed ID: 24771353
[TBL] [Abstract][Full Text] [Related]
3. Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.
Choi SJ; Cho JH; Im I; Lee SD; Jang JY; Oh YM; Jung YK; Jeon ES; Kim YC
Eur J Med Chem; 2010 Jun; 45(6):2578-90. PubMed ID: 20303626
[TBL] [Abstract][Full Text] [Related]
4. Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Wang YS; Strickland C; Voigt JH; Kennedy ME; Beyer BM; Senior MM; Smith EM; Nechuta TL; Madison VS; Czarniecki M; McKittrick BA; Stamford AW; Parker EM; Hunter JC; Greenlee WJ; Wyss DF
J Med Chem; 2010 Feb; 53(3):942-50. PubMed ID: 20043700
[TBL] [Abstract][Full Text] [Related]
5. Novel phenyl(thio)ureas bearing (thio)oxothiazoline group as potential BACE-1 inhibitors: synthesis and biological evaluation.
Andreoli F; Doukara AL; Mehdid MA; Vanthuyne N; Roussel C; Dessolin J; Kraus JL
J Enzyme Inhib Med Chem; 2013 Feb; 28(1):153-62. PubMed ID: 22168945
[TBL] [Abstract][Full Text] [Related]
6. Evidence for dimeric BACE-mediated APP processing.
Jin S; Agerman K; Kolmodin K; Gustafsson E; Dahlqvist C; Jureus A; Liu G; Fälting J; Berg S; Lundkvist J; Lendahl U
Biochem Biophys Res Commun; 2010 Feb; 393(1):21-7. PubMed ID: 20097169
[TBL] [Abstract][Full Text] [Related]
7. Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.
Saric A; Brügge Lz; Müller-Pompalla D; Rysiok T; Ousson S; Permanne B; Quattropani A; Busch M; Beher D; Hussain I
J Biomol Screen; 2013 Mar; 18(3):277-85. PubMed ID: 23023105
[TBL] [Abstract][Full Text] [Related]
8. Study on the active mechanism of β-secretase inhibitors by molecular simulations.
Tian YL; Lv M; Li JJ; Xu T; Zhai HL; Zhang XY
Eur J Pharm Sci; 2015 Aug; 76():138-48. PubMed ID: 25965961
[TBL] [Abstract][Full Text] [Related]
9. Dynamic Simulation, Docking and DFT Studies Applied to a Set of Anti-Acetylcholinesterase Inhibitors in the enzyme β-Secretase (BACE-1): An Important Therapeutic Target in Alzheimer`s disease.
Silva-Junior EF; Barcellos Franca PH; Quintans-Junior LJ; Mendonca-Junior FJB; Scotti L; Scotti MT; de Aquino TM; de Araujo-Junior JX
Curr Comput Aided Drug Des; 2017 Nov; 13(4):266-274. PubMed ID: 28382866
[TBL] [Abstract][Full Text] [Related]
10. High throughput virtual screening and E-pharmacophore filtering in the discovery of new BACE-1 inhibitors.
Muthusamy K; Singh KhD; Chinnasamy S; Nagamani S; Krishnasamy G; Thiyagarajan C; Premkumar P; Anusuyadevi M
Interdiscip Sci; 2013 Jun; 5(2):119-26. PubMed ID: 23740393
[TBL] [Abstract][Full Text] [Related]
11. Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?
Nawrot B
Acta Biochim Pol; 2004; 51(2):431-44. PubMed ID: 15218540
[TBL] [Abstract][Full Text] [Related]
12. Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies.
John S; Thangapandian S; Sakkiah S; Lee KW
BMC Bioinformatics; 2011 Feb; 12 Suppl 1(Suppl 1):S28. PubMed ID: 21342558
[TBL] [Abstract][Full Text] [Related]
13. Novel non-peptide beta-secretase inhibitors derived from structure-based virtual screening and bioassay.
Xu W; Chen G; Liew OW; Zuo Z; Jiang H; Zhu W
Bioorg Med Chem Lett; 2009 Jun; 19(12):3188-92. PubMed ID: 19447035
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates.
Sund C; Belda O; Borkakoti N; Lindberg J; Derbyshire D; Vrang L; Hamelink E; Åhgren C; Woestenenk E; Wikström K; Eneroth A; Lindström E; Kalayanov G
Bioorg Med Chem Lett; 2012 Nov; 22(21):6721-7. PubMed ID: 23010268
[TBL] [Abstract][Full Text] [Related]
15. Comprehensive 3D-QSAR and binding mode of BACE-1 inhibitors using R-group search and molecular docking.
Huang D; Liu Y; Shi B; Li Y; Wang G; Liang G
J Mol Graph Model; 2013 Sep; 45():65-83. PubMed ID: 24004830
[TBL] [Abstract][Full Text] [Related]
16. A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.
Tanahashi H; Tabira T
Neurosci Lett; 2007 Nov; 428(2-3):103-8. PubMed ID: 17961921
[TBL] [Abstract][Full Text] [Related]
17. Progress toward the discovery and development of efficacious BACE inhibitors.
Durham TB; Shepherd TA
Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
[TBL] [Abstract][Full Text] [Related]
18. Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
Zhu Z; Sun ZY; Ye Y; Voigt J; Strickland C; Smith EM; Cumming J; Wang L; Wong J; Wang YS; Wyss DF; Chen X; Kuvelkar R; Kennedy ME; Favreau L; Parker E; McKittrick BA; Stamford A; Czarniecki M; Greenlee W; Hunter JC
J Med Chem; 2010 Feb; 53(3):951-65. PubMed ID: 20043696
[TBL] [Abstract][Full Text] [Related]
19. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.
Shimmyo Y; Kihara T; Akaike A; Niidome T; Sugimoto H
Biochim Biophys Acta; 2008 May; 1780(5):819-25. PubMed ID: 18295609
[TBL] [Abstract][Full Text] [Related]
20. Sequential virtual screening approach to the identification of small organic molecules as potential BACE-1 inhibitors.
Chiriano G; Sartini A; Mancini F; Andrisano V; Bolognesi ML; Roberti M; Recanatini M; Carloni P; Cavalli A
Chem Biol Drug Des; 2011 Apr; 77(4):268-71. PubMed ID: 21244641
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
