211 related articles for article (PubMed ID: 24114789)
1. High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation.
Alsenaidy MA; Kim JH; Majumdar R; Weis DD; Joshi SB; Tolbert TJ; Middaugh CR; Volkin DB
J Pharm Sci; 2013 Nov; 102(11):3942-56. PubMed ID: 24114789
[TBL] [Abstract][Full Text] [Related]
2. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions.
Bhambhani A; Kissmann JM; Joshi SB; Volkin DB; Kashi RS; Middaugh CR
J Pharm Sci; 2012 Mar; 101(3):1120-35. PubMed ID: 22147527
[TBL] [Abstract][Full Text] [Related]
3. Correlating the Impact of Well-Defined Oligosaccharide Structures on Physical Stability Profiles of IgG1-Fc Glycoforms.
More AS; Toprani VM; Okbazghi SZ; Kim JH; Joshi SB; Middaugh CR; Tolbert TJ; Volkin DB
J Pharm Sci; 2016 Feb; 105(2):588-601. PubMed ID: 26869421
[TBL] [Abstract][Full Text] [Related]
4. Physical stability comparisons of IgG1-Fc variants: effects of N-glycosylation site occupancy and Asp/Gln residues at site Asn 297.
Alsenaidy MA; Okbazghi SZ; Kim JH; Joshi SB; Middaugh CR; Tolbert TJ; Volkin DB
J Pharm Sci; 2014 Jun; 103(6):1613-1627. PubMed ID: 24740840
[TBL] [Abstract][Full Text] [Related]
5. Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.
Majumdar R; Esfandiary R; Bishop SM; Samra HS; Middaugh CR; Volkin DB; Weis DD
MAbs; 2015; 7(1):84-95. PubMed ID: 25524268
[TBL] [Abstract][Full Text] [Related]
6. Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies.
Thakkar SV; Sahni N; Joshi SB; Kerwin BA; He F; Volkin DB; Middaugh CR
Protein Sci; 2013 Oct; 22(10):1295-305. PubMed ID: 23893936
[TBL] [Abstract][Full Text] [Related]
7. Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies.
Thakkar SV; Joshi SB; Jones ME; Sathish HA; Bishop SM; Volkin DB; Middaugh CR
J Pharm Sci; 2012 Sep; 101(9):3062-77. PubMed ID: 22581714
[TBL] [Abstract][Full Text] [Related]
8. Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoforms.
Wada R; Matsui M; Kawasaki N
MAbs; 2019; 11(2):350-372. PubMed ID: 30466347
[TBL] [Abstract][Full Text] [Related]
9. Stability of monoclonal antibodies at high-concentration: head-to-head comparison of the IgG1 and IgG4 subclass.
Neergaard MS; Nielsen AD; Parshad H; Van De Weert M
J Pharm Sci; 2014 Jan; 103(1):115-27. PubMed ID: 24282022
[TBL] [Abstract][Full Text] [Related]
10. Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody.
Oyama H; Koga H; Tadokoro T; Maenaka K; Shiota A; Yokoyama M; Noda M; Torisu T; Uchiyama S
J Pharm Sci; 2020 Jan; 109(1):308-315. PubMed ID: 31669120
[TBL] [Abstract][Full Text] [Related]
11. Effects of acid exposure on the conformation, stability, and aggregation of monoclonal antibodies.
Ejima D; Tsumoto K; Fukada H; Yumioka R; Nagase K; Arakawa T; Philo JS
Proteins; 2007 Mar; 66(4):954-62. PubMed ID: 17154421
[TBL] [Abstract][Full Text] [Related]
12. Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments.
Welfle K; Misselwitz R; Hausdorf G; Höhne W; Welfle H
Biochim Biophys Acta; 1999 Apr; 1431(1):120-31. PubMed ID: 10209285
[TBL] [Abstract][Full Text] [Related]
13. Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis.
Bommana R; Chai Q; Schöneich C; Weiss WF; Majumdar R
J Pharm Sci; 2018 Jun; 107(6):1498-1511. PubMed ID: 29408480
[TBL] [Abstract][Full Text] [Related]
14. Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability.
Goldberg DS; Bishop SM; Shah AU; Sathish HA
J Pharm Sci; 2011 Apr; 100(4):1306-15. PubMed ID: 20960568
[TBL] [Abstract][Full Text] [Related]
15. Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques.
Kalonia C; Kumru OS; Kim JH; Middaugh CR; Volkin DB
J Pharm Sci; 2013 Dec; 102(12):4256-67. PubMed ID: 24122556
[TBL] [Abstract][Full Text] [Related]
16. Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles.
Alsenaidy MA; Jain NK; Kim JH; Middaugh CR; Volkin DB
Front Pharmacol; 2014; 5():39. PubMed ID: 24659968
[TBL] [Abstract][Full Text] [Related]
17. High Throughput Prediction Approach for Monoclonal Antibody Aggregation at High Concentration.
Zidar M; Šušterič A; Ravnik M; Kuzman D
Pharm Res; 2017 Sep; 34(9):1831-1839. PubMed ID: 28593474
[TBL] [Abstract][Full Text] [Related]
18. Investigating the Degradation Behaviors of a Therapeutic Monoclonal Antibody Associated with pH and Buffer Species.
Zheng S; Qiu D; Adams M; Li J; Mantri RV; Gandhi R
AAPS PharmSciTech; 2017 Jan; 18(1):42-48. PubMed ID: 26340951
[TBL] [Abstract][Full Text] [Related]
19. High throughput thermostability screening of monoclonal antibody formulations.
He F; Hogan S; Latypov RF; Narhi LO; Razinkov VI
J Pharm Sci; 2010 Apr; 99(4):1707-20. PubMed ID: 19780136
[TBL] [Abstract][Full Text] [Related]
20. Effects of Glycan Structure on the Stability and Receptor Binding of an IgG4-Fc.
Kang H; Larson NR; White DR; Middaugh CR; Tolbert T; Schöneich C
J Pharm Sci; 2020 Jan; 109(1):677-689. PubMed ID: 31669606
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
