1587 related articles for article (PubMed ID: 24117942)
1. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
[TBL] [Abstract][Full Text] [Related]
2. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
3. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
Hahn S; Brüning T; Ness J; Czirr E; Baches S; Gijsen H; Korth C; Pietrzik CU; Bulic B; Weggen S
J Neurochem; 2011 Feb; 116(3):385-95. PubMed ID: 21091478
[TBL] [Abstract][Full Text] [Related]
4. Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation.
Guardia-Laguarta C; Pera M; Clarimón J; Molinuevo JL; Sánchez-Valle R; Lladó A; Coma M; Gómez-Isla T; Blesa R; Ferrer I; Lleó A
J Neuropathol Exp Neurol; 2010 Jan; 69(1):53-9. PubMed ID: 20010303
[TBL] [Abstract][Full Text] [Related]
5. Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.
Dimitrov M; Alattia JR; Lemmin T; Lehal R; Fligier A; Houacine J; Hussain I; Radtke F; Dal Peraro M; Beher D; Fraering PC
Nat Commun; 2013; 4():2246. PubMed ID: 23907250
[TBL] [Abstract][Full Text] [Related]
6. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
7. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
[TBL] [Abstract][Full Text] [Related]
8. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
[TBL] [Abstract][Full Text] [Related]
9. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
10. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
[TBL] [Abstract][Full Text] [Related]
11. Alzheimer's disease.
De-Paula VJ; Radanovic M; Diniz BS; Forlenza OV
Subcell Biochem; 2012; 65():329-52. PubMed ID: 23225010
[TBL] [Abstract][Full Text] [Related]
12. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.
Devkota S; Williams TD; Wolfe MS
J Biol Chem; 2021; 296():100281. PubMed ID: 33450230
[TBL] [Abstract][Full Text] [Related]
13. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
14. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
15. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
Zhang C; Browne A; Kim DY; Tanzi RE
Curr Alzheimer Res; 2010 Feb; 7(1):21-6. PubMed ID: 20205669
[TBL] [Abstract][Full Text] [Related]
16. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations.
Pimenova AA; Goate AM
Neurobiol Dis; 2020 May; 138():104785. PubMed ID: 32032730
[TBL] [Abstract][Full Text] [Related]
17. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
Kretner B; Fukumori A; Kuhn PH; Pérez-Revuelta BI; Lichtenthaler SF; Haass C; Steiner H
J Neurochem; 2013 Apr; 125(1):144-56. PubMed ID: 23237322
[TBL] [Abstract][Full Text] [Related]
18. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.
Herl L; Thomas AV; Lill CM; Banks M; Deng A; Jones PB; Spoelgen R; Hyman BT; Berezovska O
Mol Cell Neurosci; 2009 Jun; 41(2):166-74. PubMed ID: 19281847
[TBL] [Abstract][Full Text] [Related]
19. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Kokawa A; Ishihara S; Fujiwara H; Nobuhara M; Iwata M; Ihara Y; Funamoto S
Acta Neuropathol Commun; 2015 Nov; 3():66. PubMed ID: 26531305
[TBL] [Abstract][Full Text] [Related]
20. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
