128 related articles for article (PubMed ID: 24131420)
1. Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity.
Renck D; Machado P; Souto AA; Rosado LA; Erig T; Campos MM; Farias CB; Roesler R; Timmers LF; de Souza ON; Santos DS; Basso LA
J Med Chem; 2013 Nov; 56(21):8892-902. PubMed ID: 24131420
[TBL] [Abstract][Full Text] [Related]
2. In silico/in vitro study of hybrid D-modified steroidal alkylator anticancer activity using uridine phosphorylase as target protein.
Geromichalos GD; Geromichalou E; Camoutsis C; Kontos M; Dalezis P; Papageorgiou A; Grivas AA; Tsigris C; Trafalis DT
Anticancer Res; 2011 Mar; 31(3):831-42. PubMed ID: 21498703
[TBL] [Abstract][Full Text] [Related]
3. The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
Renck D; Ducati RG; Palma MS; Santos DS; Basso LA
Arch Biochem Biophys; 2010 May; 497(1-2):35-42. PubMed ID: 20226755
[TBL] [Abstract][Full Text] [Related]
4. Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Al Safarjalani ON; Rais R; Shi J; Schinazi RF; Naguib FN; el Kouni MH
Cancer Chemother Pharmacol; 2006 Nov; 58(5):692-8. PubMed ID: 16528530
[TBL] [Abstract][Full Text] [Related]
5. Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
Chen CL; Chang DM; Chen TC; Lee CC; Hsieh HH; Huang FC; Huang KF; Guh JH; Lin JJ; Huang HS
Eur J Med Chem; 2013 Feb; 60():29-41. PubMed ID: 23279865
[TBL] [Abstract][Full Text] [Related]
6. CPBMF65, a synthetic human uridine phosphorylase-1 inhibitor, reduces HepG2 cell proliferation through cell cycle arrest and senescence.
da Silva EFG; Lima KG; Krause GC; Haute GV; Pedrazza L; Catarina AV; Gassen RB; de Souza Basso B; Dias HB; Luft C; Garcia MCR; Costa BP; Antunes GL; Basso LA; Donadio MVF; Machado P; de Oliveira JR
Invest New Drugs; 2020 Dec; 38(6):1653-1663. PubMed ID: 32367200
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Tzioumaki N; Manta S; Tsoukala E; Vande Voorde J; Liekens S; Komiotis D; Balzarini J
Eur J Med Chem; 2011 Apr; 46(4):993-1005. PubMed ID: 21330014
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin.
Zhao LM; Zhang LM; Liu JJ; Wan LJ; Chen YQ; Zhang SQ; Yan ZW; Jiang JH
Eur J Med Chem; 2012 Jan; 47(1):255-60. PubMed ID: 22093761
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase.
Yano S; Kazuno H; Sato T; Suzuki N; Emura T; Wierzba K; Yamashita J; Tada Y; Yamada Y; Fukushima M; Asao T
Bioorg Med Chem; 2004 Jul; 12(13):3443-50. PubMed ID: 15186830
[TBL] [Abstract][Full Text] [Related]
10. Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis.
Renck D; Santos AA; Machado P; Petersen GO; Lopes TG; Santos DS; Campos MM; Basso LA
Invest New Drugs; 2014 Dec; 32(6):1301-7. PubMed ID: 25052233
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of octadecylamine-retinoic acid conjugate for enhanced cytotoxic effects of 5-FU using LDL targeted nanostructured lipid carriers.
Varshosaz J; Hassanzadeh F; Sadeghi H; Andalib S
Eur J Med Chem; 2012 Aug; 54():429-38. PubMed ID: 22687440
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2 antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer.
Luo D; Zhang Y; Yang S; Tian X; Lv Y; Guo Z; Liu X; Han G; Liu S; Wang W; Cui S; Qu X; Wan S
Eur J Med Chem; 2021 Dec; 225():113775. PubMed ID: 34411894
[TBL] [Abstract][Full Text] [Related]
13. Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
Cao D; Russell RL; Zhang D; Leffert JJ; Pizzorno G
Cancer Res; 2002 Apr; 62(8):2313-7. PubMed ID: 11956089
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties.
Dulla B; Kirla KT; Rathore V; Deora GS; Kavela S; Maddika S; Chatti K; Reiser O; Iqbal J; Pal M
Org Biomol Chem; 2013 May; 11(19):3103-7. PubMed ID: 23575971
[TBL] [Abstract][Full Text] [Related]
15. Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Martin DS; Stolfi RL; Sawyer RC
Cancer Chemother Pharmacol; 1989; 24(1):9-14. PubMed ID: 2720896
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors.
Zhang YB; Wang XL; Liu W; Yang YS; Tang JF; Zhu HL
Bioorg Med Chem; 2012 Nov; 20(21):6356-65. PubMed ID: 23018096
[TBL] [Abstract][Full Text] [Related]
17. Synthesis, biological evaluation, and molecular docking studies of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)aniline derivatives as novel anticancer agents.
Huang XF; Lu X; Zhang Y; Song GQ; He QL; Li QS; Yang XH; Wei Y; Zhu HL
Bioorg Med Chem; 2012 Aug; 20(16):4895-900. PubMed ID: 22819191
[TBL] [Abstract][Full Text] [Related]
18. Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro.
Berényi Á; Frotscher M; Marchais-Oberwinkler S; Hartmann RW; Minorics R; Ocsovszki I; Falkay G; Zupkó I
J Enzyme Inhib Med Chem; 2013 Aug; 28(4):695-703. PubMed ID: 22471733
[TBL] [Abstract][Full Text] [Related]
19. Rapid synthesis of new DNMT inhibitors derivatives of procainamide.
Halby L; Champion C; Sénamaud-Beaufort C; Ajjan S; Drujon T; Rajavelu A; Ceccaldi A; Jurkowska R; Lequin O; Nelson WG; Guy A; Jeltsch A; Guianvarc'h D; Ferroud C; Arimondo PB
Chembiochem; 2012 Jan; 13(1):157-65. PubMed ID: 22170584
[TBL] [Abstract][Full Text] [Related]
20. 19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Holland SK; Bergman AM; Zhao Y; Adams ER; Pizzorno G
Magn Reson Med; 1997 Dec; 38(6):907-16. PubMed ID: 9402191
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]