These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 24147825)

  • 1. 2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.
    Ferrari S; Calò S; Leone R; Luciani R; Costantino L; Sammak S; Di Pisa F; Pozzi C; Mangani S; Costi MP
    J Med Chem; 2013 Nov; 56(22):9356-60. PubMed ID: 24147825
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
    Anderson AC; Perry KM; Freymann DM; Stroud RM
    J Mol Biol; 2000 Mar; 297(3):645-57. PubMed ID: 10731418
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
    Almog R; Waddling CA; Maley F; Maley GF; Van Roey P
    Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
    Sayre PH; Finer-Moore JS; Fritz TA; Biermann D; Gates SB; MacKellar WC; Patel VF; Stroud RM
    J Mol Biol; 2001 Nov; 313(4):813-29. PubMed ID: 11697906
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
    Stout TJ; Stroud RM
    Structure; 1996 Jan; 4(1):67-77. PubMed ID: 8805515
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
    Phan J; Koli S; Minor W; Dunlap RB; Berger SH; Lebioda L
    Biochemistry; 2001 Feb; 40(7):1897-902. PubMed ID: 11329255
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2'-deoxyuridine 5'-phosphate.
    Kalman TI; Nie Z; Kamat A
    Bioorg Med Chem Lett; 2000 Feb; 10(4):391-4. PubMed ID: 10714507
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
    Fritz TA; Tondi D; Finer-Moore JS; Costi MP; Stroud RM
    Chem Biol; 2001 Oct; 8(10):981-95. PubMed ID: 11590022
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 5-propynylpyrimidine nucleoside derivatives: rationally designed mechanism-based inactivators of thymidylate synthase.
    Kalman TI; Nie Z; Kamat A
    Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):869-71. PubMed ID: 11563134
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
    Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT
    Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
    Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
    J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
    Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
    J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
    Newby Z; Lee TT; Morse RJ; Liu Y; Liu L; Venkatraman P; Santi DV; Finer-Moore JS; Stroud RM
    Biochemistry; 2006 Jun; 45(24):7415-28. PubMed ID: 16768437
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.
    Tochowicz A; Dalziel S; Eidam O; O'Connell JD; Griner S; Finer-Moore JS; Stroud RM
    J Med Chem; 2013 Jul; 56(13):5446-55. PubMed ID: 23710599
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation.
    Kaiyawet N; Rungrotmongkol T; Hannongbua S
    J Chem Inf Model; 2013 Jun; 53(6):1315-23. PubMed ID: 23705822
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Biochemistry. DNA building block reinvented.
    Murzin AG
    Science; 2002 Jul; 297(5578):61-2. PubMed ID: 12029066
    [No Abstract]   [Full Text] [Related]  

  • 17. The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.
    Anderson AC; O'Neil RH; DeLano WL; Stroud RM
    Biochemistry; 1999 Oct; 38(42):13829-36. PubMed ID: 10529228
    [TBL] [Abstract][Full Text] [Related]  

  • 18. An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
    Sage CR; Rutenber EE; Stout TJ; Stroud RM
    Biochemistry; 1996 Dec; 35(50):16270-81. PubMed ID: 8973201
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.
    Parchina A; Froeyen M; Margamuljana L; Rozenski J; De Jonghe S; Briers Y; Lavigne R; Herdewijn P; Lescrinier E
    ChemMedChem; 2013 Aug; 8(8):1373-83. PubMed ID: 23836539
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.
    Matthews DA; Villafranca JE; Janson CA; Smith WW; Welsh K; Freer S
    J Mol Biol; 1990 Aug; 214(4):937-48. PubMed ID: 2201779
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.