These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
72 related articles for article (PubMed ID: 24148123)
1. [Structure of the Smoothened receptor]. Ruat M; Hoch L; Faure H; Rognan D Med Sci (Paris); 2013 Oct; 29(10):855-60. PubMed ID: 24148123 [TBL] [Abstract][Full Text] [Related]
2. Molecular modeling study on the dynamical structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation. Bai Q; Shen Y; Jin N; Liu H; Yao X Biochim Biophys Acta; 2014 Jul; 1840(7):2128-38. PubMed ID: 24637074 [TBL] [Abstract][Full Text] [Related]
3. Structure of the human smoothened receptor bound to an antitumour agent. Wang C; Wu H; Katritch V; Han GW; Huang XP; Liu W; Siu FY; Roth BL; Cherezov V; Stevens RC Nature; 2013 May; 497(7449):338-43. PubMed ID: 23636324 [TBL] [Abstract][Full Text] [Related]
4. Scaffold hopping approach to a new series of smoothened antagonists. Lu W; Geng D; Sun Z; Yang Z; Ma H; Zheng J; Zhang X Bioorg Med Chem Lett; 2014 May; 24(10):2300-4. PubMed ID: 24726807 [TBL] [Abstract][Full Text] [Related]
5. Targeting of Smoothened for therapeutic gain. Ruat M; Hoch L; Faure H; Rognan D Trends Pharmacol Sci; 2014 May; 35(5):237-46. PubMed ID: 24703627 [TBL] [Abstract][Full Text] [Related]
7. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Nachtergaele S; Whalen DM; Mydock LK; Zhao Z; Malinauskas T; Krishnan K; Ingham PW; Covey DF; Siebold C; Rohatgi R Elife; 2013 Oct; 2():e01340. PubMed ID: 24171105 [TBL] [Abstract][Full Text] [Related]
8. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Manetti F; Faure H; Roudaut H; Gorojankina T; Traiffort E; Schoenfelder A; Mann A; Solinas A; Taddei M; Ruat M Mol Pharmacol; 2010 Oct; 78(4):658-65. PubMed ID: 20664000 [TBL] [Abstract][Full Text] [Related]
9. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. Rominger CM; Bee WL; Copeland RA; Davenport EA; Gilmartin A; Gontarek R; Hornberger KR; Kallal LA; Lai Z; Lawrie K; Lu Q; McMillan L; Truong M; Tummino PJ; Turunen B; Will M; Zuercher WJ; Rominger DH J Pharmacol Exp Ther; 2009 Jun; 329(3):995-1005. PubMed ID: 19304771 [TBL] [Abstract][Full Text] [Related]
10. Structural basis of Smoothened regulation by its extracellular domains. Byrne EFX; Sircar R; Miller PS; Hedger G; Luchetti G; Nachtergaele S; Tully MD; Mydock-McGrane L; Covey DF; Rambo RP; Sansom MSP; Newstead S; Rohatgi R; Siebold C Nature; 2016 Jul; 535(7613):517-522. PubMed ID: 27437577 [TBL] [Abstract][Full Text] [Related]
11. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Gorojankina T; Hoch L; Faure H; Roudaut H; Traiffort E; Schoenfelder A; Girard N; Mann A; Manetti F; Solinas A; Petricci E; Taddei M; Ruat M Mol Pharmacol; 2013 May; 83(5):1020-9. PubMed ID: 23448715 [TBL] [Abstract][Full Text] [Related]
12. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Roudaut H; Traiffort E; Gorojankina T; Vincent L; Faure H; Schoenfelder A; Mann A; Manetti F; Solinas A; Taddei M; Ruat M Mol Pharmacol; 2011 Mar; 79(3):453-60. PubMed ID: 21177415 [TBL] [Abstract][Full Text] [Related]
13. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Yang X; Mao F; Lv X; Zhang Z; Fu L; Lu Y; Wu W; Zhou Z; Zhang L; Zhao Y J Cell Sci; 2013 Sep; 126(Pt 18):4230-8. PubMed ID: 23843610 [TBL] [Abstract][Full Text] [Related]
14. TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling. Ibuki N; Ghaffari M; Pandey M; Iu I; Fazli L; Kashiwagi M; Tojo H; Nakanishi O; Gleave ME; Cox ME Int J Cancer; 2013 Oct; 133(8):1955-66. PubMed ID: 23564295 [TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and structure--activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists. Ma H; Lu W; Sun Z; Luo L; Geng D; Yang Z; Li E; Zheng J; Wang M; Zhang H; Yang S; Zhang X Eur J Med Chem; 2015 Jan; 89():721-32. PubMed ID: 25462278 [TBL] [Abstract][Full Text] [Related]
16. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Tao H; Jin Q; Koo DI; Liao X; Englund NP; Wang Y; Ramamurthy A; Schultz PG; Dorsch M; Kelleher J; Wu X Chem Biol; 2011 Apr; 18(4):432-7. PubMed ID: 21513879 [TBL] [Abstract][Full Text] [Related]
17. Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics. Peukert S; Miller-Moslin K ChemMedChem; 2010 Apr; 5(4):500-12. PubMed ID: 20229564 [TBL] [Abstract][Full Text] [Related]
18. 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. Miller-Moslin K; Peukert S; Jain RK; McEwan MA; Karki R; Llamas L; Yusuff N; He F; Li Y; Sun Y; Dai M; Perez L; Michael W; Sheng T; Lei H; Zhang R; Williams J; Bourret A; Ramamurthy A; Yuan J; Guo R; Matsumoto M; Vattay A; Maniara W; Amaral A; Dorsch M; Kelleher JF J Med Chem; 2009 Jul; 52(13):3954-68. PubMed ID: 19469545 [TBL] [Abstract][Full Text] [Related]
19. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Dijkgraaf GJ; Alicke B; Weinmann L; Januario T; West K; Modrusan Z; Burdick D; Goldsmith R; Robarge K; Sutherlin D; Scales SJ; Gould SE; Yauch RL; de Sauvage FJ Cancer Res; 2011 Jan; 71(2):435-44. PubMed ID: 21123452 [TBL] [Abstract][Full Text] [Related]
20. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. Solinas A; Faure H; Roudaut H; Traiffort E; Schoenfelder A; Mann A; Manetti F; Taddei M; Ruat M J Med Chem; 2012 Feb; 55(4):1559-71. PubMed ID: 22268551 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]