BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

211 related articles for article (PubMed ID: 24152295)

  • 1. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).
    Hsu KL; Tsuboi K; Chang JW; Whitby LR; Speers AE; Pugh H; Cravatt BF
    J Med Chem; 2013 Nov; 56(21):8270-9. PubMed ID: 24152295
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.
    Hsu KL; Tsuboi K; Whitby LR; Speers AE; Pugh H; Inloes J; Cravatt BF
    J Med Chem; 2013 Nov; 56(21):8257-69. PubMed ID: 24152245
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis.
    Manterola A; Bernal-Chico A; Cipriani R; Ruiz A; Pérez-Samartín A; Moreno-Rodríguez M; Hsu KL; Cravatt BF; Brown JM; Rodríguez-Puertas R; Matute C; Mato S
    Neuropharmacology; 2018 Oct; 141():181-191. PubMed ID: 30171986
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
    Aaltonen N; Savinainen JR; Ribas CR; Rönkkö J; Kuusisto A; Korhonen J; Navia-Paldanius D; Häyrinen J; Takabe P; Käsnänen H; Pantsar T; Laitinen T; Lehtonen M; Pasonen-Seppänen S; Poso A; Nevalainen T; Laitinen JT
    Chem Biol; 2013 Mar; 20(3):379-90. PubMed ID: 23521796
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.
    Patel JZ; Nevalainen TJ; Savinainen JR; Adams Y; Laitinen T; Runyon RS; Vaara M; Ahenkorah S; Kaczor AA; Navia-Paldanius D; Gynther M; Aaltonen N; Joharapurkar AA; Jain MR; Haka AS; Maxfield FR; Laitinen JT; Parkkari T
    ChemMedChem; 2015 Feb; 10(2):253-65. PubMed ID: 25504894
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparative molecular field analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors.
    Kaczor AA; Targowska-Duda KM; Patel JZ; Laitinen T; Parkkari T; Adams Y; Nevalainen TJ; Poso A
    J Mol Model; 2015 Oct; 21(10):250. PubMed ID: 26350245
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.
    Patel JZ; van Bruchem J; Laitinen T; Kaczor AA; Navia-Paldanius D; Parkkari T; Savinainen JR; Laitinen JT; Nevalainen TJ
    Bioorg Med Chem; 2015 Oct; 23(19):6335-45. PubMed ID: 26344596
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB
    Owens RA; Mustafa MA; Ignatowska-Jankowska BM; Damaj MI; Beardsley PM; Wiley JL; Niphakis MJ; Cravatt BF; Lichtman AH
    Neuropharmacology; 2017 Oct; 125():80-86. PubMed ID: 28673548
    [TBL] [Abstract][Full Text] [Related]  

  • 9. WWL70 attenuates PGE
    Tanaka M; Moran S; Wen J; Affram K; Chen T; Symes AJ; Zhang Y
    J Neuroinflammation; 2017 Jan; 14(1):7. PubMed ID: 28086912
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Therapeutic potential of targeting α/β-Hydrolase domain-containing 6 (ABHD6).
    Deng H; Li W
    Eur J Med Chem; 2020 Jul; 198():112353. PubMed ID: 32371333
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).
    Parkkari T; Haavikko R; Laitinen T; Navia-Paldanius D; Rytilahti R; Vaara M; Lehtonen M; Alakurtti S; Yli-Kauhaluoma J; Nevalainen T; Savinainen JR; Laitinen JT
    PLoS One; 2014; 9(5):e98286. PubMed ID: 24879289
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
    Aghazadeh Tabrizi M; Baraldi PG; Baraldi S; Ruggiero E; De Stefano L; Rizzolio F; Di Cesare Mannelli L; Ghelardini C; Chicca A; Lapillo M; Gertsch J; Manera C; Macchia M; Martinelli A; Granchi C; Minutolo F; Tuccinardi T
    J Med Chem; 2018 Feb; 61(3):1340-1354. PubMed ID: 29309142
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Highly predictive ligand-based pharmacophore and homology models of ABHD6.
    Bowman AL; Makriyannis A
    Chem Biol Drug Des; 2013 Mar; 81(3):382-8. PubMed ID: 23110439
    [TBL] [Abstract][Full Text] [Related]  

  • 14. N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases.
    Otrubova K; Chatterjee S; Ghimire S; Cravatt BF; Boger DL
    Bioorg Med Chem; 2019 Apr; 27(8):1693-1703. PubMed ID: 30879861
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors.
    Malamas MS; Lamani M; Farah SI; Mohammad KA; Miyabe CY; Rajarshi G; Wu S; Zvonok N; Chandrashekhar H; Wood J; Makriyannis A
    ChemMedChem; 2023 Nov; 18(21):e202100406. PubMed ID: 34486233
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis.
    Wen J; Ribeiro R; Tanaka M; Zhang Y
    Neuropharmacology; 2015 Dec; 99():196-209. PubMed ID: 26189763
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
    Thomas G; Betters JL; Lord CC; Brown AL; Marshall S; Ferguson D; Sawyer J; Davis MA; Melchior JT; Blume LC; Howlett AC; Ivanova PT; Milne SB; Myers DS; Mrak I; Leber V; Heier C; Taschler U; Blankman JL; Cravatt BF; Lee RG; Crooke RM; Graham MJ; Zimmermann R; Brown HA; Brown JM
    Cell Rep; 2013 Oct; 5(2):508-20. PubMed ID: 24095738
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids.
    Bottemanne P; Paquot A; Ameraoui H; Alhouayek M; Muccioli GG
    FASEB J; 2019 Jun; 33(6):7635-7646. PubMed ID: 30896979
    [TBL] [Abstract][Full Text] [Related]  

  • 19. WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms.
    Wen J; Jones M; Tanaka M; Selvaraj P; Symes AJ; Cox B; Zhang Y
    J Neuroinflammation; 2018 Jan; 15(1):9. PubMed ID: 29310667
    [TBL] [Abstract][Full Text] [Related]  

  • 20.
    ; ; . PubMed ID:
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 11.