These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

112 related articles for article (PubMed ID: 24157366)

  • 1. Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
    Debenham JS; Graham TH; Verras A; Zhang Y; Clements MJ; Kuethe JT; Madsen-Duggan C; Liu W; Bhatt UR; Chen D; Chen Q; Garcia-Calvo M; Geissler WM; He H; Li X; Lisnock J; Shen Z; Tong X; Tung EC; Wiltsie J; Xu S; Hale JJ; Pinto S; Shen DM
    Bioorg Med Chem Lett; 2013 Dec; 23(23):6228-33. PubMed ID: 24157366
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
    Graham TH; Liu W; Verras A; Sebhat IK; Xiong Y; Bleasby K; Bhatt UR; Chen Q; Garcia-Calvo M; Geissler WM; Gorski JN; He H; Lassman ME; Lisnock J; Li X; Shen Z; Tong X; Tung EC; Wiltsie J; Xiao J; Xie D; Xu S; Hale JJ; Pinto S; Shen DM
    Bioorg Med Chem Lett; 2012 Apr; 22(8):2811-7. PubMed ID: 22444683
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
    Graham TH; Liu W; Verras A; Reibarkh M; Bleasby K; Bhatt UR; Chen Q; Garcia-Calvo M; Geissler WM; Gorski JN; He H; Lassman ME; Lisnock J; Li X; Shen Z; Tong X; Tung EC; Wiltsie J; Xie D; Xu S; Xiao J; Hale JJ; Pinto S; Shen DM
    Bioorg Med Chem Lett; 2012 Apr; 22(8):2818-22. PubMed ID: 22444685
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
    Shen HC; Ding FX; Zhou C; Xiong Y; Verras A; Chabin RM; Xu S; Tong X; Xie D; Lassman ME; Bhatt UR; Garcia-Calvo MM; Geissler W; Shen Z; Chen D; Sinharoy R; Hale JJ; Tata JR; Pinto S; Shen DM; Colletti SL
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1299-305. PubMed ID: 21315588
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
    Shen HC; Ding FX; Jiang J; Verras A; Chabin RM; Xu S; Tong X; Chen Q; Xie D; Lassman ME; Bhatt UR; Garcia-Calvo MM; Geissler W; Shen Z; Murphy BA; Gorski JN; Wiltsie J; SinhaRoy R; Hale JJ; Pinto S; Shen DM
    Bioorg Med Chem Lett; 2012 Feb; 22(4):1550-6. PubMed ID: 22264488
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
    Wu Z; Yang C; Xiong Y; Feng Z; Lombardo M; Verras A; Chabin RM; Xu S; Tong X; Xie D; Lassman ME; Bhatt UR; Garcia-Calvo MM; Geissler W; Shen Z; Chen Q; Sinharoy R; Hale JJ; Tata JR; Pinto S; Shen DM; Colletti SL
    Bioorg Med Chem Lett; 2012 Feb; 22(4):1774-8. PubMed ID: 22248857
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors.
    Graham TH; Shu M; Verras A; Chen Q; Garcia-Calvo M; Li X; Lisnock J; Tong X; Tung EC; Wiltsie J; Hale JJ; Pinto S; Shen DM
    Bioorg Med Chem Lett; 2014 Apr; 24(7):1657-60. PubMed ID: 24636945
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
    Zhou C; Garcia-Calvo M; Pinto S; Lombardo M; Feng Z; Bender K; Pryor KD; Bhatt UR; Chabin RM; Geissler WM; Shen Z; Tong X; Zhang Z; Wong KK; Roy RS; Chapman KT; Yang L; Xiong Y
    J Med Chem; 2010 Oct; 53(19):7251-63. PubMed ID: 20857914
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.
    Graham TH
    Expert Opin Ther Pat; 2017 Oct; 27(10):1077-1088. PubMed ID: 28699813
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.
    Wu Z; Yang C; Graham TH; Verras A; Chabin RM; Xu S; Tong X; Xie D; Lassman ME; Bhatt UR; Garcia-Calvo MM; Shen Z; Chen Q; Bleasby K; Sinharoy R; Hale JJ; Tata JR; Pinto S; Colletti SL; Shen DM
    Bioorg Med Chem Lett; 2012 Feb; 22(4):1727-30. PubMed ID: 22290078
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
    Churcher I; Beher D; Best JD; Castro JL; Clarke EE; Gentry A; Harrison T; Hitzel L; Kay E; Kerrad S; Lewis HD; Morentin-Gutierrez P; Mortishire-Smith R; Oakley PJ; Reilly M; Shaw DE; Shearman MS; Teall MR; Williams S; Wrigley JD
    Bioorg Med Chem Lett; 2006 Jan; 16(2):280-4. PubMed ID: 16275079
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
    Graham TH; Shen HC; Liu W; Xiong Y; Verras A; Bleasby K; Bhatt UR; Chabin RM; Chen D; Chen Q; Garcia-Calvo M; Geissler WM; He H; Lassman ME; Shen Z; Tong X; Tung EC; Xie D; Xu S; Colletti SL; Tata JR; Hale JJ; Pinto S; Shen DM
    Bioorg Med Chem Lett; 2012 Jan; 22(1):658-65. PubMed ID: 22079761
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.
    Yun W; Ahmad M; Chen Y; Gillespie P; Conde-Knape K; Kazmer S; Li S; Qian Y; Taub R; Wertheimer SJ; Whittard T; Bolin D
    Bioorg Med Chem Lett; 2011 Dec; 21(23):7205-9. PubMed ID: 22001092
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis.
    Rabey FM; Gadepalli RS; Diano S; Cheng Q; Tabrizian T; Gailani D; Rimoldi JM; Shariat-Madar Z
    Curr Med Chem; 2012; 19(24):4194-206. PubMed ID: 22664251
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.
    Duffy JL; Kirk BA; Wang L; Eiermann GJ; He H; Leiting B; Lyons KA; Patel RA; Patel SB; Petrov A; Scapin G; Wu JK; Thornberry NA; Weber AE
    Bioorg Med Chem Lett; 2007 May; 17(10):2879-85. PubMed ID: 17350841
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents.
    Wallingford N; Perroud B; Gao Q; Coppola A; Gyengesi E; Liu ZW; Gao XB; Diament A; Haus KA; Shariat-Madar Z; Mahdi F; Wardlaw SL; Schmaier AH; Warden CH; Diano S
    J Clin Invest; 2009 Aug; 119(8):2291-303. PubMed ID: 19620781
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors.
    Kandre S; Bhagat PR; Reddy MM; Dalal R; Dixit A; Deshmukh NJ; Anthony J; Bose J; Anupindi R; Sharma R; Gupte A
    Eur J Med Chem; 2014 May; 79():203-15. PubMed ID: 24735646
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes.
    Pagire SH; Pagire HS; Lee GB; Han SJ; Kwak HJ; Kim JY; Kim KY; Rhee SD; Ryu JI; Song JS; Bae MA; Park MJ; Kim D; Lee DH; Ahn JH
    Eur J Med Chem; 2015 Aug; 101():716-35. PubMed ID: 26218650
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
    Majer P; Jackson PF; Delahanty G; Grella BS; Ko YS; Li W; Liu Q; Maclin KM; Poláková J; Shaffer KA; Stoermer D; Vitharana D; Wang EY; Zakrzewski A; Rojas C; Slusher BS; Wozniak KM; Burak E; Limsakun T; Tsukamoto T
    J Med Chem; 2003 May; 46(10):1989-96. PubMed ID: 12723961
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.
    Patel D; Jain M; Shah SR; Bahekar R; Jadav P; Joharapurkar A; Dhanesha N; Shaikh M; Sairam KV; Kapadnis P
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1111-7. PubMed ID: 22189136
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.