These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 24160292)

  • 1. Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.
    Donato MT; Jover R; Gómez-Lechón MJ
    Curr Drug Metab; 2013 Nov; 14(9):946-68. PubMed ID: 24160292
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cell lines: a tool for in vitro drug metabolism studies.
    Donato MT; Lahoz A; Castell JV; Gómez-Lechón MJ
    Curr Drug Metab; 2008 Jan; 9(1):1-11. PubMed ID: 18220566
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human hepatocytes as a tool for studying toxicity and drug metabolism.
    Gómez-Lechón MJ; Donato MT; Castell JV; Jover R
    Curr Drug Metab; 2003 Aug; 4(4):292-312. PubMed ID: 12871046
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.
    Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R
    Toxicol Sci; 2016 Jul; 152(1):214-29. PubMed ID: 27208088
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.
    Castell JV; Jover R; Martínez-Jiménez CP; Gómez-Lechón MJ
    Expert Opin Drug Metab Toxicol; 2006 Apr; 2(2):183-212. PubMed ID: 16866607
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.
    Lin J; Schyschka L; Mühl-Benninghaus R; Neumann J; Hao L; Nussler N; Dooley S; Liu L; Stöckle U; Nussler AK; Ehnert S
    Arch Toxicol; 2012 Jan; 86(1):87-95. PubMed ID: 21735230
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines.
    Kvist AJ; Kanebratt KP; Walentinsson A; Palmgren H; O'Hara M; Björkbom A; Andersson LC; Ahlqvist M; Andersson TB
    Biochem Pharmacol; 2018 Sep; 155():124-140. PubMed ID: 29953844
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A transcriptomic study suggesting human iPSC-derived hepatocytes potentially offer a better in vitro model of hepatotoxicity than most hepatoma cell lines.
    Gao X; Liu Y
    Cell Biol Toxicol; 2017 Aug; 33(4):407-421. PubMed ID: 28144825
    [TBL] [Abstract][Full Text] [Related]  

  • 9. HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.
    Lübberstedt M; Müller-Vieira U; Mayer M; Biemel KM; Knöspel F; Knobeloch D; Nüssler AK; Gerlach JC; Zeilinger K
    J Pharmacol Toxicol Methods; 2011; 63(1):59-68. PubMed ID: 20460162
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.
    Hewitt NJ; Lechón MJ; Houston JB; Hallifax D; Brown HS; Maurel P; Kenna JG; Gustavsson L; Lohmann C; Skonberg C; Guillouzo A; Tuschl G; Li AP; LeCluyse E; Groothuis GM; Hengstler JG
    Drug Metab Rev; 2007; 39(1):159-234. PubMed ID: 17364884
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing.
    Gómez-Lechón MJ; Tolosa L; Donato MT
    Expert Opin Drug Metab Toxicol; 2017 Feb; 13(2):137-148. PubMed ID: 27671376
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Can hepatoma cell lines be redifferentiated to be used in drug metabolism studies?
    Martínez-Jiménez CP; Jover R; Gómez-Lechón MJ; Castell JV
    Altern Lab Anim; 2004 Jun; 32 Suppl 1A():65-74. PubMed ID: 23577436
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In vitro evaluation of potential hepatotoxicity induced by drugs.
    Gómez-Lechón MJ; Lahoz A; Gombau L; Castell JV; Donato MT
    Curr Pharm Des; 2010 Jun; 16(17):1963-77. PubMed ID: 20236064
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity.
    Ruoß M; Damm G; Vosough M; Ehret L; Grom-Baumgarten C; Petkov M; Naddalin S; Ladurner R; Seehofer D; Nussler A; Sajadian S
    Int J Mol Sci; 2019 Jan; 20(2):. PubMed ID: 30654452
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models.
    Donato MT; Castell JV; Gómez-Lechón MJ
    J Hepatol; 1999 Sep; 31(3):542-9. PubMed ID: 10488716
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hepatocytes as a tool in drug metabolism, transport and safety evaluations in drug discovery.
    Sahi J; Grepper S; Smith C
    Curr Drug Discov Technol; 2010 Sep; 7(3):188-98. PubMed ID: 20843293
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
    Gómez-Lechón MJ; Castell JV; Donato MT
    Chem Biol Interact; 2007 May; 168(1):30-50. PubMed ID: 17134688
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.
    Rodríguez-Antona C; Donato MT; Boobis A; Edwards RJ; Watts PS; Castell JV; Gómez-Lechón MJ
    Xenobiotica; 2002 Jun; 32(6):505-20. PubMed ID: 12160483
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The application of HepRG cells in evaluation of cytochrome P450 induction properties of drug compounds.
    Andersson TB
    Methods Mol Biol; 2010; 640():375-87. PubMed ID: 20645063
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism.
    Chitrangi S; Nair P; Khanna A
    Toxicol In Vitro; 2017 Feb; 38():8-18. PubMed ID: 27794450
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.